Patents by Inventor Peilin Yu
Peilin Yu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8283455Abstract: The present invention describes novel compounds and methods for capping reactive groups on support and during multistep synthesis. These new capping reagents are also useful for high quality synthesis on solid supports and surfaces used as microarrays, biosensors, or in general as biochips. The compounds are also useful for controlling surface density of reactive groups on a support. The compounds may also be used to modify the hydrophilic/hydrophobic characteristics of a surface or a molecule. The compounds have functional utility in various applications in the fields of genomics, proteomics, diagnostics and medicine.Type: GrantFiled: March 22, 2011Date of Patent: October 9, 2012Inventors: Xiaolian Gao, Peilin Yu
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Publication number: 20120029166Abstract: A method of modulation of synthesis capacity on and cleavage properties of synthetic oligomers from solid support is described. The method utilizes linker molecules attached to a solid surface and co-coupling agents that have similar reactivities to the coupling compounds with the surface functional groups. The preferred linker molecules provide an increased density of polymers and more resistance to cleavage from the support surface. The method is particularly useful for synthesis of oligonucleotides, oligonucleotides microarrays, peptides, and peptide microarrays. The stable linkers are also coupled to anchor molecules for synthesis of DNA oligonucleotides using on support purification, eliminating time-consuming chromatography and metal cation presence. Oligonucleotides thus obtained can be directly used for mass analysis, DNA amplification and ligation, hybridization, and many other applications.Type: ApplicationFiled: October 11, 2011Publication date: February 2, 2012Applicant: THE REGENTS OF THE UNVERSITY OF MICHIGANInventors: Xiaolian Gao, Hua Zhang, Peilin Yu, Eric Leproust, Jean Philippe Pellois, Qin Xiang, Xiaochuan Zhou
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Publication number: 20110288285Abstract: The present invention describes novel compounds and methods for capping reactive groups on support and during multistep synthesis. These new capping reagents are also useful for high quality synthesis on solid supports and surfaces used as microarrays, biosensors, or in general as biochips. The compounds are also useful for controlling surface density of reactive groups on a support. The compounds may also be used to modify the hydrophilic/hydrophobic characteristics of a surface or a molecule. The compounds have functional utility in various applications in the fields of genomics, proteomics, diagnostics and medicine.Type: ApplicationFiled: March 22, 2011Publication date: November 24, 2011Inventors: Xiaolian Gao, Peilin Yu
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Patent number: 8053187Abstract: A method of modulation of synthesis capacity on and cleavage properties of synthetic oligomers from solid support is described. The method utilizes linker molecules attached to a solid surface and co-coupling agents that have similar reactivities to the coupling compounds with the surface functional groups. The preferred linker molecules provide an increased density of polymers and more resistance to cleavage from the support surface. The method is particularly useful for synthesis of oligonucleotides, oligonucleotides microarrays, peptides, and peptide microarrays. The stable linkers are also coupled to anchor molecules for synthesis of DNA oligonucleotides using on support purification, eliminating time-consuming chromatography and metal cation presence. Oligonucleotides thus obtained can be directly used for mass analysis, DNA amplification and ligation, hybridization, and many other applications.Type: GrantFiled: October 4, 2010Date of Patent: November 8, 2011Assignee: The Regents of the University of MichiganInventors: Xiaolian Gao, Hua Zhang, Peilin Yu, Eric Leproust, Jean Philippe Pellois, Qin Xiang, Xiaochuan Zhou
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Publication number: 20110097762Abstract: A method of modulation of synthesis capacity on and cleavage properties of synthetic oligomers from solid support is described. The method utilizes linker molecules attached to a solid surface and co-coupling agents that have similar reactivities to the coupling compounds with the surface functional groups. The preferred linker molecules provide an increased density of polymers and more resistance to cleavage from the support surface. The method is particularly useful for synthesis of oligonucleotides, oligonucleotides microarrays, peptides, and peptide microarrays. The stable linkers are also coupled to anchor molecules for synthesis of DNA oligonucleotides using on support purification, eliminating time-consuming chromatography and metal cation presence. Oligonucleotides thus obtained can be directly used for mass analysis, DNA amplification and ligation, hybridization, and many other applications.Type: ApplicationFiled: October 4, 2010Publication date: April 28, 2011Applicant: THE REGENTS OF THE UNVERSITY OF MICHIGANInventors: Xiaolian Gao, Hua Zhang, Peilin Yu, Eric Leproust, Jean Philippe Pellois, Qin Xiang, Xiaochuan Zhou
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Patent number: 7923550Abstract: The present invention describes novel compounds and methods for capping reactive groups on support and during multistep synthesis. These new capping reagents are also useful for high quality synthesis on solid supports and surfaces used as microarrays, biosensors, or in general as biochips. The compounds are also useful for controlling surface density of reactive groups on a support. The compounds may also be used to modify the hydrophilic/hydrophobic characteristics of a surface or a molecule. The compounds have functional utility in various applications in the fields of genomics, proteomics, diagnostics and medicine.Type: GrantFiled: April 14, 2004Date of Patent: April 12, 2011Inventors: Xiaolian Gao, Peilin Yu
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Patent number: 7807807Abstract: A method of modulation of synthesis capacity on and cleavage properties of synthetic oligomers from solid support is described. The method utilizes linker molecules attached to a solid surface and co-coupling agents that have similar reactivities to the coupling compounds with the surface functional groups. The preferred linker molecules provide an increased density of polymers and more resistance to cleavage from the support surface. The method is particularly useful for synthesis of oligonucleotides, oligonucleotides microarrays, peptides, and peptide microarrays. The stable linkers are also coupled to anchor molecules for synthesis of DNA oligonucleotides using on support purification, eliminating time-consuming chromatography and metal cation presence. Oligonucleotides thus obtained can be directly used for mass analysis, DNA amplification and ligation, hybridization, and many other applications.Type: GrantFiled: June 29, 2009Date of Patent: October 5, 2010Assignee: The Regents of the University of MichiganInventors: Xiaolian Gao, Hua Zhang, Peilin Yu, Eric Leproust, Jean Philippe Pellois, Qin Xiang, Xiaochuan Zhou
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Publication number: 20100210478Abstract: The present invention relates to quantitative and quantity aspects of array synthesis and array uses as a device for high capacity producing synthetic molecules for off-array surface applications and as an assay device for on-array surface applications.Type: ApplicationFiled: June 29, 2007Publication date: August 19, 2010Inventors: Xiaolian Gao, Kiaochun Zhou, Xiaolin Zhang, Ailing Hong, Qi Zhu, Peilin Yu
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Publication number: 20100093974Abstract: A method of modulation of synthesis capacity on and cleavage properties of synthetic oligomers from solid support is described. The method utilizes linker molecules attached to a solid surface and co-coupling agents that have similar reactivities to the coupling compounds with the surface functional groups. The preferred linker molecules provide an increased density of polymers and more resistance to cleavage from the support surface. The method is particularly useful for synthesis of oligonucleotides, oligonucleotides microarrays, peptides, and peptide microarrays. The stable linkers are also coupled to anchor molecules for synthesis of DNA oligonucleotides using on support purification, eliminating time-consuming chromatography and metal cation presence. Oligonucleotides thus obtained can be directly used for mass analysis, DNA amplification and ligation, hybridization, and many other applications.Type: ApplicationFiled: June 29, 2009Publication date: April 15, 2010Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGANInventors: Xiaolian Gao, Hua Zhang, Peilin Yu, Eric Leproust, Jean Philippe Pellois, Qin Xiang, Xiaochuan Zhou
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Patent number: 7553958Abstract: A method of modulation of synthesis capacity on and cleavage properties of synthetic oligomers from solid support is described. The method utilizes linker molecules attached to a solid surface and co-coupling agents that have similar reactivities to the coupling compounds with the surface functional groups. The preferred linker molecules provide an increased density of polymers and more resistance to cleavage from the support surface. The method is particularly useful for synthesis of oligonucleotides, oligonucleotides microarrays, peptides, and peptide microarrays. The stable linkers are also coupled to anchor molecules for synthesis of DNA oligonucleotides using on support purification, eliminating time-consuming chromatography and metal cation presence. Oligonucleotides thus obtained can be directly used for mass analysis, DNA amplification and ligation, hybridization, and many other applications.Type: GrantFiled: March 21, 2007Date of Patent: June 30, 2009Assignee: The Regents of the University of MichiganInventors: Xiaolian Gao, Hua Zhang, Peilin Yu, Eric Leproust, Jean Philippe Pellois, Qin Xiang, Xiaochuan Zhou
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Publication number: 20080091005Abstract: Modified nucleotides are disclosed for use in single molecule sequencing, methods for making the modified nucleotides and method for using the modified nucleotides. Linkers for making the modified nucleotide are also disclosed.Type: ApplicationFiled: July 20, 2007Publication date: April 17, 2008Applicants: VISIGEN BIOTECHNOLOGIES, INC., APPLIED BIOSYSTEMSInventors: Hongyi Wang, Xiaolian Gao, Peilin Yu, Mitsu Reddy, Susan Hardin, Tommie Lincecum, Amy Williams, Norha Deluge, Yuri Belosludtsev, Steven Menchen, Joe Lam, Jer-Kang Chen
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Publication number: 20070287832Abstract: A method of modulation of synthesis capacity on and cleavage properties of synthetic oligomers from solid support is described. The method utilizes linker molecules attached to a solid surface and co-coupling agents that have similar reactivities to the coupling compounds with the surface functional groups. The preferred linker molecules provide an increased density of polymers and more resistance to cleavage from the support surface. The method is particularly useful for synthesis of oligonucleotides, oligonucleotides microarrays, peptides, and peptide microarrays. The stable linkers are also coupled to anchor molecules for synthesis of DNA oligonucleotides using on support purification, eliminating time-consuming chromatography and metal cation presence. Oligonucleotides thus obtained can be directly used for mass analysis, DNA amplification and ligation, hybridization, and many other applications.Type: ApplicationFiled: March 21, 2007Publication date: December 13, 2007Inventors: Xiaolian Gao, Hua Zhang, Peilin Yu, Eric Leproust, Jean Pellois, Qin Xiang, Xiaochuan Zhou
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Patent number: 7211654Abstract: A method of modulation of synthesis capacity on and cleavage properties of synthetic oligomers from solid support is described. The method utilizes linker molecules attached to a solid surface and co-coupling agents that have similar reactivities to the coupling compounds with the surface functional groups. The preferred linker molecules provide an increased density of polymers and more resistance to cleavage from the support surface. The method is particularly useful for synthesis of oligonucleotides, oligonucleotides microarrays, peptides, and peptide microarrays. The stable linkers are also coupled to anchor molecules for synthesis of DNA oligonucleotides using on support purification, eliminating time-consuming chromatography and metal cation presence. Oligonucleotides thus obtained can be directly used for mass analysis, DNA amplification and ligation, hybridization, and many other applications.Type: GrantFiled: March 13, 2002Date of Patent: May 1, 2007Assignee: Regents of the University of MichiganInventors: Xiaolian Gao, Hua Zhang, Peilin Yu, Eric Leproust, Jean Philippe Pellois, Qin Xiang, Xiaochuan Zhou
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Publication number: 20030120035Abstract: A method of modulation of synthesis capacity on and cleavage properties of synthetic oligomers from solid support is described. The method utilizes linker molecules attached to a solid surface and co-coupling agents that have similar reactivities to the coupling compounds with the surface functional groups. The preferred linker molecules provide an increased density of polymers and more resistance to cleavage from the support surface. The method is particularly useful for synthesis of oligonucleotides, oligonucleotides microarrays, peptides, and peptide microarrays. The stable linkers are also coupled to anchor molecules for synthesis of DNA oligonucleotides using on support purification, eliminating time-consuming chromatography and metal cation presence. Oligonucleotides thus obtained can be directly used for mass analysis, DNA amplification and ligation, hybridization, and many other applications.Type: ApplicationFiled: March 13, 2002Publication date: June 26, 2003Applicant: The Regents Of The University Of MichiganInventors: Xiaolian Gao, Hua Zhang, Peilin Yu, Eric Leproust, Jean Philippe Pellois, Qin Xiang, Xiaochuan Zhou