Patents by Inventor Peiman Hematti

Peiman Hematti has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Macrophage Cell Therapy to Treat Orthopedic Injury
    Publication number: 20240009233
    Abstract: An ex vivo generated population of tissue-specific alternatively-activated macrophages and methods of making and using such macrophages for treating orthopedic injury are provided.
    Type: Application
    Filed: July 12, 2023
    Publication date: January 11, 2024
    Inventors: Peiman Hematti, Connie Chamberlain, Anna Elizabeth Breiner Clements, Ray Vanderby, John A. Kink
  • GENERATION OF THERAPEUTIC CELLS USING EXTRACELLULAR COMPONENTS OF TARGET ORGANS
    Publication number: 20230407256
    Abstract: The invention relates to an ex vivo generated population of tissue-specific anti-inflammatory macrophages and methods of making and using such macrophages.
    Type: Application
    Filed: August 17, 2023
    Publication date: December 21, 2023
    Inventors: Peiman Hematti, Eric G. Schmuck, John A. Kink, Amish N. Raval
  • Generation of therapeutic cells using extracellular components of target organs
    Patent number: 11760975
    Abstract: The invention relates to an ex vivo generated population of tissue-specific anti-inflammatory macrophages and methods of making and using such macrophages.
    Type: Grant
    Filed: March 30, 2018
    Date of Patent: September 19, 2023
    Assignee: Wisconsin Alumi Research Foundation
    Inventors: Peiman Hematti, Eric G. Schmuck, John A. Kink, Amish N. Raval
  • Macrophage cell therapy to treat orthopedic injury
    Patent number: 11738046
    Abstract: An ex vivo generated population of tissue-specific alternatively-activated macrophages and methods of making and using such macrophages for treating orthopedic injury are provided.
    Type: Grant
    Filed: November 2, 2018
    Date of Patent: August 29, 2023
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Peiman Hematti, Connie Chamberlain, Anna Elizabeth Breiner Clements, Ray Vanderby, John A. Kink
  • T CELL SPECIFIC BIOMARKERS FOR PREDICTING GRAFT-VS-HOST DISEASE AND HEMATOPOIETIC MALIGNANCY RELAPSE FOLLOWING HEMATOPOIETIC STEM CELL TRANSPLANTATION AND TREATMENT THEREOF
    Publication number: 20230221318
    Abstract: The present disclosure generally relates to methods for diagnosing, predicting and treating graft-vs-host disease and/or relapse of a hematologic malignancy following hematopoietic stem cell transplantation based on T-cell specific biomarkers.
    Type: Application
    Filed: January 6, 2023
    Publication date: July 13, 2023
    Inventors: Nicholas Hess, Christian Capitini, Kalyan Nadiminti, Peiman Hematti, Jenny Gumperz
  • LPS priming of stromal cells to generate LPS-specific exosome educated macrophages
    Patent number: 11499730
    Abstract: The disclosure relates to an ex vivo generated population of educated macrophages specific to LPS and methods of making and using such macrophages.
    Type: Grant
    Filed: February 12, 2019
    Date of Patent: November 15, 2022
    Assignee: WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Peiman Hematti, John A. Kink, Christian Capitini
  • LPS Priming of Stromal Cells to Generate LPS-Specific Exosome Educated Macrophages
    Publication number: 20220349599
    Abstract: The disclosure relates to an ex vivo generated population of educated macrophages specific to LPS and methods of making and using such macrophages.
    Type: Application
    Filed: July 12, 2022
    Publication date: November 3, 2022
    Inventors: Peiman Hematti, John A. Kink, Christian Capitini
  • XENO-FREE GENERATION OF TISSUE-SPECIFIC PROGENITOR CELLS
    Publication number: 20220127577
    Abstract: The invention relates to purified, tissue-specific progenitors, methods of making and using such tissue-specific progenitors.
    Type: Application
    Filed: October 6, 2021
    Publication date: April 28, 2022
    Inventors: Peiman Hematti, Jaehyup Kim
  • Use of Toll-Like Receptor 4 Agonists to Treat Inflammation and Tissue Injury
    Publication number: 20220127579
    Abstract: The disclosure relates to populations of educated macrophages and monocytes generated ex vivo or in vivo, and methods of making and using the same using lipid A aminoalkylglucosaminide phosphate molecules, such as CRX molecules or extracellular vesicles (EVs) from mesenchymal stromal cells (MSC) stimulated with CRX molecules. Also described are EVs and methods for making and using the same from MSCs exposed to CRX.
    Type: Application
    Filed: October 22, 2021
    Publication date: April 28, 2022
    Inventors: Peiman HEMATTI, John KINK, Christian CAPITINI, Matthew FORSBERG, Nicholas HESS, Zachary ROSENKRANS, Reinier HERNANDEZ
  • Xeno-free generation of tissue-specific progenitor cells
    Patent number: 11162074
    Abstract: The invention relates to purified, tissue-specific progenitors, methods of making and using such tissue-specific progenitors.
    Type: Grant
    Filed: June 11, 2018
    Date of Patent: November 2, 2021
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Peiman Hematti, Jaehyup Kim
  • METHODS OF T CELL EXPANSION AND ACTIVATION
    Publication number: 20200149010
    Abstract: The present disclosure relates to methods, cells, and compositions for preparing T cell populations and compositions for adoptive cell therapy. In particular, provided herein are methods for efficiently expanding and activating T cell populations for genetic engineering and adoptive T cell immunotherapies. Also provided are cells and compositions produced by the methods and methods of their use.
    Type: Application
    Filed: January 7, 2020
    Publication date: May 14, 2020
    Inventors: Peiman Hematti, Debra Bloom
  • Methods of T cell expansion and activation
    Patent number: 10563172
    Abstract: The present disclosure relates to methods, cells, and compositions for preparing T cell populations and compositions for adoptive cell therapy. In particular, provided herein are methods for efficiently expanding and activating T cell populations for genetic engineering and adoptive T cell immunotherapies. Also provided are cells and compositions produced by the methods and methods of their use.
    Type: Grant
    Filed: March 14, 2017
    Date of Patent: February 18, 2020
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Peiman Hematti, Debra Bloom
  • LPS PRIMING OF STROMAL CELLS TO GENERATE LPS-SPECIFIC EXOSOME EDUCATED MACROPHAGES
    Publication number: 20190249144
    Abstract: The disclosure relates to an ex vivo generated population of educated macrophages specific to LPS and methods of making and using such macrophages.
    Type: Application
    Filed: February 12, 2019
    Publication date: August 15, 2019
    Inventors: Peiman Hematti, John A. Kink
  • MACROPHAGE CELL THERAPY TO TREAT ORTHOPEDIC INJURY
    Publication number: 20190134090
    Abstract: An ex vivo generated population of tissue-specific alternatively-activated macrophages and methods of making and using such macrophages for treating orthopedic injury are provided.
    Type: Application
    Filed: November 2, 2018
    Publication date: May 9, 2019
    Inventors: Peiman Hematti, Connie Chamberlain, Anna Elizabeth Breiner Clements, Ray Vanderby, John A. Kink
  • Use of mesenchymal stem cell-educated macrophages to treat and prevent graft versus host disease and radiation-induced injury
    Patent number: 10166254
    Abstract: The present invention relates to methods for treating and preventing graft-versus-host disease (GVHD) and radiation-induced tissue damage or organ failure. More particularly, methods of the present invention comprise administering a therapeutically effective amount of mesenchymal stem cell-educated macrophages (MEMs) to a subject to treat or prevent GVHD, bone marrow failure, radiation-induced tissue damage or organ failure, or a condition associated with aberrant inflammation.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: January 1, 2019
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Peiman Hematti, Myriam N. Bouchlaka, Christian M. Capitini
  • XENO-FREE GENERATION OF TISSUE-SPECIFIC PROGENITOR CELLS
    Publication number: 20180291345
    Abstract: The invention relates to purified, tissue-specific progenitors, methods of making and using such tissue-specific progenitors.
    Type: Application
    Filed: June 11, 2018
    Publication date: October 11, 2018
    Inventors: Peiman Hematti, Jaehyup Kim
  • GENERATION OF THERAPEUTIC CELLS USING EXTRACELLULAR COMPONENTS OF TARGET ORGANS
    Publication number: 20180282698
    Abstract: The invention relates to an ex vivo generated population of tissue-specific anti-inflammatory macrophages and methods of making and using such macrophages.
    Type: Application
    Filed: March 30, 2018
    Publication date: October 4, 2018
    Inventors: Peiman Hematti, Eric G. Schmuck, John A. Kink, Amish N. Raval
  • Xeno-free generation of tissue-specific progenitor cells
    Patent number: 9994819
    Abstract: The invention relates to purified, tissue-specific progenitors, methods of making and using such tissue-specific progenitors.
    Type: Grant
    Filed: May 13, 2016
    Date of Patent: June 12, 2018
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Peiman Hematti, Jaehyup Kim
  • METHODS OF T CELL EXPANSION AND ACTIVATION
    Publication number: 20170260506
    Abstract: The present disclosure relates to methods, cells, and compositions for preparing T cell populations and compositions for adoptive cell therapy. In particular, provided herein are methods for efficiently expanding and activating T cell populations for genetic engineering and adoptive T cell immunotherapies. Also provided are cells and compositions produced by the methods and methods of their use.
    Type: Application
    Filed: March 14, 2017
    Publication date: September 14, 2017
    Inventors: Peiman Hematti, Debra Bloom
  • XENO-FREE GENERATION OF TISSUE-SPECIFIC PROGENITOR CELLS
    Publication number: 20160257933
    Abstract: The invention relates to purified, tissue-specific progenitors, methods of making and using such tissue-specific progenitors.
    Type: Application
    Filed: May 13, 2016
    Publication date: September 8, 2016
    Inventors: Peiman Hematti, Jaehyup Kim