Abstract: The present invention provides a preparation of a Siglec-15 binding protein and the use thereof, and specifically relates to an isolated antigen-binding protein, which comprises HCDR3. Provided is the use of the antigen-binding protein in the prevention and treatment of diseases.

Abstract: Provided is an GARP protein antibody, and a cell comprising or expressing the GA RP protein antibody. The GARP protein antibody binds to human GARP/human TGF-?1 complex with a KD value of about 1.0E-12 or less. Also provided are a pharmaceutical combination comprising the GARP protein antibody and an immune checkpoint inhibitor and use thereof.

Abstract: Disclosed are a method of inspecting a printing quality of a 3D printing object using a femtosecond laser beam during a 3D printing process, and an apparatus and a 3D printing system for the same. A laser beam is irradiated from a femtosecond laser source disposed coaxially with a 3D printing laser source to inspect a state of the printing object. The laser beam generated by the femtosecond laser source is separated into a pump laser beam and a probe laser beam. The printing laser beam irradiated from a 3D printing laser source or the pump laser beam is irradiated onto a printing object to generate ultrasonic waves. To measure the ultrasonic waves, a probe laser beam is irradiated onto the printing object. The probe laser beam reflected by the printing object is detected. The quality of the printing object is inspected by analyzing the reflected probe laser beam.

Abstract: Disclosed are a femtosecond laser-based ultrasonic measuring apparatus for a 3D printing process, and a 3D printing system including the apparatus. The apparatus includes a femtosecond laser source for generating a femtosecond laser beam irradiated to inspect a state of a printing object formed by melting a base material by a printing laser beam irradiated from the laser source for 3D printing, a beam splitter for separating the femtosecond laser beam generated by the femtosecond laser source into a pump laser beam and a probe laser beam, an electric/acoustic optical modulator for modulating the pump laser beam, a time delay unit for delaying the probe laser beam, a photo detector for detecting the probe laser beam reflected by the printing object, and a lock-in amplifier for detect an amplitude and a phase of the output signal from the photo detector. The femtosecond laser source is disposed coaxially with a laser source for 3D printing.

Abstract: An example photoionization detector is provided. The example photoionization detector includes an insulation spacer component and a signal collection electrode component disposed on the first surface of the insulation spacer component. In some examples, the signal collection electrode component includes a first electrode layer and a second electrode layer.

Abstract: The present application relates to an antigen-binding protein comprising amino acid mutations compared with the light and heavy chain variable region sequences of omalizumab. The antigen-binding protein of the present application is an anti-IgE engineered antibody. The present application also relates to pharmaceutical compositions comprising the antigen-binding protein, and methods thereof for alleviation or treatment of diseases associated with abnormal level of IgE.

Abstract: A method of feedback controlling a 3D printing process in real time, and a system therefor are disclosed. The method includes collecting big data, generated through 3D printing experiments, related to process variables of 3D printing, measurement signals, and 3D printing quality of the 3D printing object; building an artificial neural network model by performing machine-learning based on the collected big data; evaluating whether or not a 3D printing quality of the 3D printing object is abnormal in real time based on an actual measurement signal of the 3D printing object and the artificial neural network model; and feedback controlling printing quality of the 3D printing object in real time based on the evaluation result of whether or not the 3D printing quality of the 3D printing object is abnormal.

Abstract: A method of feedback controlling a 3D printing process in real time, and a system therefor are disclosed. The method includes collecting big data, generated through 3D printing experiments, related to process variables of 3D printing, measurement signals, and 3D printing quality of the 3D printing object; building an artificial neural network model by performing machine-learning based on the collected big data; evaluating whether or not a 3D printing quality of the 3D printing object is abnormal in real time based on an actual measurement signal of the 3D printing object and the artificial neural network model; and feedback controlling printing quality of the 3D printing object in real time based on the evaluation result of whether or not the 3D printing quality of the 3D printing object is abnormal.

Abstract: A method of feedback controlling a 3D printing process in real time, and a system therefor are disclosed. The method includes collecting big data, generated through 3D printing experiments, related to process variables of 3D printing, measurement signals, and 3D printing quality of the 3D printing object; building an artificial neural network model by performing machine-learning based on the collected big data; evaluating whether or not a 3D printing quality of the 3D printing object is abnormal in real time based on an actual measurement signal of the 3D printing object and the artificial neural network model; and feedback controlling printing quality of the 3D printing object in real time based on the evaluation result of whether or not the 3D printing quality of the 3D printing object is abnormal.

Abstract: Methods, apparatuses and systems for providing a switching component are disclosed herein. An example switching component may comprise: A switching component comprising: a housing; a carrier body disposed within the housing; a first pair of contact pads disposed on a first surface of the carrier body; and a second pair of contact pads disposed on a second surface of the carrier body, wherein each pair of contact pads is configured to independently make contact with adjacent bridge contact pads in order to actuate an electrical bridge in response to movement of the carrier body.

Abstract: In a method of inspecting a structure, a first ultrasonic signal generated from a target structure by a first laser beam is received. The first ultrasonic signal is generated by providing the first laser beam generated from a first excitation unit to the target structure. A second ultrasonic signal generated from the target structure by a second laser beam different from the first laser beam is received. The second ultrasonic signal is generated by providing the second laser beam generated from a second excitation unit to the target structure. A third ultrasonic signal generated from the target structure by the first and second laser beams is received. The third ultrasonic signal is generated by simultaneously providing the first and second laser beams to the target structure. It is determined whether the target structure is damaged based on first, second and third ultrasonic frequency spectra that are obtained by converting the first, second and third ultrasonic signals, respectively.

Abstract: Disclosed are an integrated inspection system for a 3D printing process using a thermal image and a laser ultrasound wave and a 3D printing system having the inspection system. The inspection system includes a thermal imaging camera for creating a thermal image of a molten pool formed in a printing object when a base material supplied to the printing object is melted by a laser beam irradiated from a 3D printing laser source, a laser ultrasonic device for receiving a laser ultrasonic wave included in the laser beam reflected from the printing object, and a control unit for estimating a physical property of the printing object and detecting a defect of the printing object based on the thermal image created by the thermal imaging camera and the laser ultrasound wave received by the laser ultrasonic device. The thermal imaging camera and the laser ultrasonic device are disposed coaxially with the 3D printing laser source.

Abstract: Disclosed are a femtosecond laser-based ultrasonic measuring apparatus for a 3D printing process, and a 3D printing system including the apparatus. The apparatus includes a femtosecond laser source for generating a femtosecond laser beam irradiated to inspect a state of a printing object formed by melting a base material by a printing laser beam irradiated from the laser source for 3D printing, a beam splitter for separating the femtosecond laser beam generated by the femtosecond laser source into a pump laser beam and a probe laser beam, an electric/acoustic optical modulator for modulating the pump laser beam, a time delay unit for delaying the probe laser beam, a photo detector for detecting the probe laser beam reflected by the printing object, and a lock-in amplifier for detect an amplitude and a phase of the output signal from the photo detector. The femtosecond laser source is disposed coaxially with a laser source for 3D printing.

Abstract: Disclosed are a method of inspecting a printing quality of a 3D printing object using a femtosecond laser beam during a 3D printing process, and an apparatus and a 3D printing system for the same. A laser beam is irradiated from a femtosecond laser source disposed coaxially with a 3D printing laser source to inspect a state of the printing object. The laser beam generated by the femtosecond laser source is separated into a pump laser beam and a probe laser beam. The printing laser beam irradiated from a 3D printing laser source or the pump laser beam is irradiated onto a printing object to generate ultrasonic waves. To measure the ultrasonic waves, a probe laser beam is irradiated onto the printing object. The probe laser beam reflected by the printing object is detected. The quality of the printing object is inspected by analyzing the reflected probe laser beam.

Abstract: A method of feedback controlling a 3D printing process in real time, and a system therefor are disclosed. The method includes collecting big data, generated through 3D printing experiments, related to process variables of 3D printing, measurement signals, and 3D printing quality of the 3D printing object; building an artificial neural network model by performing machine-learning based on the collected big data; evaluating whether or not a 3D printing quality of the 3D printing object is abnormal in real time based on an actual measurement signal of the 3D printing object and the artificial neural network model; and feedback controlling printing quality of the 3D printing object in real time based on the evaluation result of whether or not the 3D printing quality of the 3D printing object is abnormal.

Abstract: In a method of inspecting a structure, a first ultrasonic signal generated from a target structure by a first laser beam is received. The first ultrasonic signal is generated by providing the first laser beam generated from a first excitation unit to the target structure. A second ultrasonic signal generated from the target structure by a second laser beam different from the first laser beam is received. The second ultrasonic signal is generated by providing the second laser beam generated from a second excitation unit to the target structure. A third ultrasonic signal generated from the target structure by the first and second laser beams is received. The third ultrasonic signal is generated by simultaneously providing the first and second laser beams to the target structure. It is determined whether the target structure is damaged based on first, second and third ultrasonic frequency spectra that are obtained by converting the first, second and third ultrasonic signals, respectively.

Abstract: Disclosed are dipyridyl alkaloid, a preparation method therefor and use thereof. The structure of the dipyridyl alkaloid is as shown in formula I. The dipyridyl alkaloid has a tumor cell proliferation inhibitory activity and can be used as a tumor cell proliferation inhibitor or for developing an anti-tumor drug.

Abstract: Embodiments relate generally to methods and systems for balancing the internal pressure of a gas detector. A method for venting internal pressure changes of a gas detector may comprise providing an inlet to a sensor located within a housing of the gas detector; isolating the sensor from the rest of the interior of the housing; providing at least one vent between the interior of the housing and the external environment, wherein the sensor is isolated from airflow into and out of the vent; and preventing one or more elements from entering the interior of the housing through the at least one vent via a breathable membrane aligned with the at least one vent.

Abstract: Embodiments relate generally to systems and methods for dissipating electric charge within a particulate matter sensor, and reducing the effects of electromagnetic interference within the particulate matter sensor. A particulate matter sensor may comprise an airflow channel; a light source configured to pass light through the airflow channel; a photodetector configured to receive light from the light source after it passes through the airflow channel; a printed circuit board coupled to the photodetector having a processor and a memory storing instructions which, when executed by the processor, determines an indication of a mass concentration of particles in the airflow channel based on an output of the photodetector; and a shield cover configured to attach to and cover at least a portion of the printed circuit board, and configured to reduce the effects of electromagnetic interference within the particulate matter sensor.

Abstract: The present invention relates to a safety diagnosis method for a structure using a nonlinear ultrasonic wave modulation technique. The safety diagnosis method includes: making the structure vibrate by applying signals of different ultrasonic frequencies; converting the responses of the structure generated by the vibration into digital signals; extracting first modulation signals by subtracting the harmonic responses and the linear responses of the signals of different ultrasonic frequencies from the digital signals and synchronously demodulating the digital signals; constructing a first sideband spectrogram by combining the first modulation signals generated by continuously changing at least frequency among the signals of different ultrasonic frequencies; and deciding whether the structure is cracked based on the first sideband spectrogram.