Abstract: A method of alleviation or therapy of tinnitus in a subject in need thereof includes the step of administrating a CCK-B receptor agonist to the subject. A CCK-B receptor agonist is used for alleviation or therapy of tinnitus in a subject in need thereof.

Abstract: Provided is a genetically engineered ??T cell, which is characterized in that a high-affinity ??TCR gene is transferred into the ??T cell, and the affinity of the high-affinity ??TCR to the specific pMHC thereof is at least two times of that of a wild-type ??TCR corresponding thereto. Further provided are a use of and a preparation method for the ??T cell.

Abstract: Provided is a genetically engineered ??T cell, which is characterized in that a high-affinity ??TCR gene is transferred into the ??T cell, and the affinity of the high-affinity ??TCR to the specific pMHC thereof is at least two times of that of a wild-type ??TCR corresponding thereto. Further provided are a use of and a preparation method for the ??T cell.

Abstract: A firecracker and firecracker arrangement. The firecracker includes an outer sheath having two face sides and that is closed at both face sides with a layer of barrier material. Pyrotechnic effect elements and a bursting charge are arranged inside the outer sheath. A first ignition line that penetrates the barrier material is guided up to the bursting charge. The bursting charge is accommodated inside a completely closed, cylindrical jacket that is arranged coaxial to the outer sheath such that a longitudinal center axes of the outer sheath and of the cylindrical jacket coincide. The first ignition line is guided through an opening in the cylindrical jacket to the bursting charge. The pyrotechnic effect elements are arranged to form a predefined geometric shape in at least one plane extending transverse to the longitudinal center axis of the outer sheath.

Abstract: A firecracker and firecracker arrangement. The firecracker includes an outer sheath having two face sides and that is closed at both face sides with a layer of barrier material. Pyrotechnic effect elements and a bursting charge are arranged inside the outer sheath. A first ignition line that penetrates the barrier material is guided up to the bursting charge. The bursting charge is accommodated inside a completely closed, cylindrical jacket that is arranged coaxial to the outer sheath such that a longitudinal center axes of the outer sheath and of the cylindrical jacket coincide. The first ignition line is guided through an opening in the cylindrical jacket to the bursting charge. The pyrotechnic effect elements are arranged to form a predefined geometric shape in at least one plane extending transverse to the longitudinal center axis of the outer sheath.