Patents by Inventor Peisheng Xu

Peisheng Xu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210369861
    Abstract: A carrier-free nanoparticle based on the self-assembly of curcumin-erlotinib conjugate (EPC) that exhibits stronger cell killing, better anti-migration effects, and anti-invasion effects for pancreatic cancer cells than the combination of free curcumin and erlotinib.
    Type: Application
    Filed: March 26, 2021
    Publication date: December 2, 2021
    Applicant: University of South Carolina
    Inventor: Peisheng Xu
  • Patent number: 11007207
    Abstract: Described is a method to fabricate a gold/mesoporous silica hybrid nanoparticle. According to the process, a gold nanoparticle can be conjugated onto the surface of a mesoporous silica nanoparticle to yield a photothermal stable theranostic platform, gold/mesoporous silica hybrid nanoparticle. The nanoparticles can be useful for disease detection, treatment, and monitoring.
    Type: Grant
    Filed: August 24, 2015
    Date of Patent: May 18, 2021
    Assignee: University of South Carolina
    Inventors: Peisheng Xu, Bei Cheng, Huacheng He
  • Patent number: 11000482
    Abstract: A nanoparticle system for the treatment of metastatic cancer is provided. The nanoparticle system includes a plurality of nanoparticles. Each of the nanoparticles includes a biodegradable matrix, a polysulphonated naphthylurea, and a chemotherapeutic agent. The biodegradable matrix can be a natural polysaccharide, a protein, a peptide, or a derivative thereof. Further, the polysulphonated naphthylurea can include suramin or a pharmaceutically acceptable salt thereof, and the chemotherapeutic agent can include an anthracycline. In addition, each of the nanoparticles has a diameter ranging from about 20 nanometers to about 400 nanometers. A method of forming the nanoparticle system and a method of treating cancer in a mammal with the nanoparticle system are also provided.
    Type: Grant
    Filed: September 12, 2019
    Date of Patent: May 11, 2021
    Assignee: University of South Carolina
    Inventor: Peisheng Xu
  • Patent number: 10842755
    Abstract: A nanoparticle suitable for delivery of an active agent across the blood-brain barrier is provided. As such, the nanoparticle can target brain tissue so that the active agent can be delivered across the blood-brain barrier to the target brain tissue. The nanoparticle includes a core that includes a core material such as a polymer or inorganic material as well as an active agent; and a shell comprising a membrane derived from a brain metastatic cancer cell, wherein the brain metastatic cancer cell facilitates transport of the nanoparticle across a blood-brain barrier. Also disclosed are methods of forming the nanoparticle and methods of using the nanoparticle.
    Type: Grant
    Filed: February 19, 2019
    Date of Patent: November 24, 2020
    Assignee: University of South Carolina
    Inventor: Peisheng Xu
  • Patent number: 10835605
    Abstract: Described is a biodegradable and biocompatible hybrid nanoparticle for use in photothermal applications. The hybrid nanoparticle includes a poly(lactide-co-glycolic acid) core and a polydopamine shell. Optionally, the hybrid nanoparticle can be loaded with an active agent such as an anti-cancer agent. The hybrid nanoparticles can include detection agents, targeting agents, etc. The nanoparticles can be useful for disease detection, treatment, and monitoring.
    Type: Grant
    Filed: September 19, 2016
    Date of Patent: November 17, 2020
    Assignee: University of South Carolina
    Inventors: Peisheng Xu, Huacheng He
  • Publication number: 20200281955
    Abstract: A hetero-targeted, dual-responsive nanogel to deliver chemotherapeutic agents to a metastatic cancer is provided. The nanogel includes a first chemotherapeutic agent, a second chemotherapeutic agent, a first targeting ligand, and a second targeting ligand. A method of treating cancer in a mammal with the nanogel are also provided.
    Type: Application
    Filed: January 7, 2020
    Publication date: September 10, 2020
    Inventors: PEISHENG XU, Binglin Sui
  • Publication number: 20200155472
    Abstract: A nanoparticle system for the treatment of metastatic cancer is provided. The nanoparticle system includes a plurality of nanoparticles. Each of the nanoparticles includes a biodegradable matrix, a polysulphonated naphthylurea, and a chemotherapeutic agent. The biodegradable matrix can be a natural polysaccharide, a protein, a peptide, or a derivative thereof. Further, the polysulphonated naphthylurea can include suramin or a pharmaceutically acceptable salt thereof, and the chemotherapeutic agent can include an anthracycline. In addition, each of the nanoparticles has a diameter ranging from about 20 nanometers to about 400 nanometers. A method of forming the nanoparticle system and a method of treating cancer in a mammal with the nanoparticle system are also provided.
    Type: Application
    Filed: September 12, 2019
    Publication date: May 21, 2020
    Inventor: PEISHENG XU
  • Publication number: 20190290592
    Abstract: A nanoparticle suitable for delivery of an active agent across the blood-brain barrier is provided. As such, the nanoparticle can target brain tissue so that the active agent can be delivered across the blood-brain barrier to the target brain tissue. The nanoparticle includes a core that includes a core material such as a polymer or inorganic material as well as an active agent; and a shell comprising a membrane derived from a brain metastatic cancer cell, wherein the brain metastatic cancer cell facilitates transport of the nanoparticle across a blood-brain barrier. Also disclosed are methods of forming the nanoparticle and methods of using the nanoparticle.
    Type: Application
    Filed: February 19, 2019
    Publication date: September 26, 2019
    Inventor: PEISHENG XU
  • Patent number: 10221271
    Abstract: Polymer/copper combinations that can selectively target and kill cancer cells are described. Materials can include the reaction product of a biocompatible hydrophilic polymer and pyridine-2-thiol containing monomer. The copolymer reaction product can include pyridine-2-thiol side groups pendant to the backbone via a disulfide linkage. The hydrophilic component can form the polymer backbone and/or can form hydrophilic pendant groups off of the backbone. Copper ions can be associated with the copolymer.
    Type: Grant
    Filed: October 13, 2017
    Date of Patent: March 5, 2019
    Assignee: University of South Carolina
    Inventors: Peisheng Xu, Huacheng He
  • Patent number: 10045945
    Abstract: Delivery systems and their methods of formation are generally provided. The delivery system can protect a delivery molecule (e.g., DNA/RNA) and deliver it into a cell via serum. In one embodiment, the method can include binding a delivery molecule with polyethylenimine such that an end of the delivery molecule is exposed; capping the end of the delivery molecule with a first biocompatible polymer to form a core; and encapsulating the core with a second biocompatible polymer. The resulting delivery system can include a delivery molecule bonded with polyethylenimine such that an end of the delivery molecule is exposed; a first biocompatible polymer electrostatically bonded to the end of the delivery molecule to form a core; and a second biocompatible polymer encapsulating the core.
    Type: Grant
    Filed: September 21, 2015
    Date of Patent: August 14, 2018
    Inventors: Peisheng Xu, Remant Bahadur K C
  • Patent number: 9962401
    Abstract: The present disclosure provides a polymer comprising a derivative of chitosan, wherein the derivative is zwitterionic, as well as methods of using the polymer. In addition, the present disclosure provides a nanoparticle structure comprising a derivative of chitosan and a dendrimer, as well as methods of utilizing the nanoparticle structure.
    Type: Grant
    Filed: November 8, 2016
    Date of Patent: May 8, 2018
    Assignee: PURDUE RESEARCH FOUNDATION
    Inventors: Yoon Yeo, Gaurav Bajaj, Peisheng Xu, Karen Liu, Eun Jung Cho
  • Publication number: 20180037687
    Abstract: Polymer/copper combinations that can selectively target and kill cancer cells are described. Materials can include the reaction product of a biocompatible hydrophilic polymer and pyridine-2-thiol containing monomer. The copolymer reaction product can include pyridine-2-thiol side groups pendant to the backbone via a disulfide linkage. The hydrophilic component can form the polymer backbone and/or can form hydrophilic pendant groups off of the backbone. Copper ions can be associated with the copolymer.
    Type: Application
    Filed: October 13, 2017
    Publication date: February 8, 2018
    Inventors: Peisheng Xu, Huacheng Hu
  • Patent number: 9861704
    Abstract: Polymer/drug conjugates that can selectively target and kill cancer cells are described. Conjugates can include a copolymer formed by the reaction of a biocompatible hydrophilic component and a disulfiram derivative. The copolymer reaction product can include additional functional groups pendant to the backbone via a disulfide linkage, for instance copper chelators. The hydrophilic component can form the polymer backbone and/or can form hydrophilic pendant groups off of the backbone. Copper ions can be associated with the copolymer.
    Type: Grant
    Filed: December 8, 2015
    Date of Patent: January 9, 2018
    Assignee: University of South Carolina
    Inventors: Peisheng Xu, Huacheng He
  • Patent number: 9822202
    Abstract: Polymer/copper combination that can selectively target and kill cancer cells are described. Materials can include the reaction product of a biocompatible hydrophilic polymer and pyridine-2-thiol containing monomer. The copolymer reaction product can include pyridine-2-thiol side groups pendant to the backbone via a disulfide linkage. The hydrophilic component can form the polymer backbone and/or can form hydrophilic pendant groups off of the backbone. Copper ions can be associated with the copolymer.
    Type: Grant
    Filed: October 20, 2015
    Date of Patent: November 21, 2017
    Assignee: University of South Carolina
    Inventors: Peisheng Xu, Huacheng He
  • Publication number: 20170143755
    Abstract: The present disclosure provides a polymer comprising a derivative of chitosan, wherein the derivative is zwitterionic, as well as methods of using the polymer. In addition, the present disclosure provides a nanoparticle structure comprising a derivative of chitosan and a dendrimer, as well as methods of utilizing the nanoparticle structure.
    Type: Application
    Filed: November 8, 2016
    Publication date: May 25, 2017
    Applicant: Purdue Research Foundation
    Inventors: Yoon YEO, Gaurav BAJAJ, Peisheng XU, Karen LIU, Eun Jung CHO
  • Publication number: 20170095558
    Abstract: Described is a biodegradable and biocompatible hybrid nanoparticle for use in photothermal applications. The hybrid nanoparticle includes a poly(lactide-co-glycolic acid) core and a polydopamine shell. Optionally, the hybrid nanoparticle can be loaded with an active agent such as an anti-cancer agent. The hybrid nanoparticles can include detection agents, targeting agents, etc. The nanoparticles can be useful for disease detection, treatment, and monitoring.
    Type: Application
    Filed: September 19, 2016
    Publication date: April 6, 2017
    Inventors: Peisheng Xu, Huacheng He
  • Patent number: 9517246
    Abstract: The present disclosure provides a polymer comprising a derivative of chitosan, wherein the derivative is zwitterionic, as well as methods of using the polymer. In addition, the present disclosure provides a nanoparticle structure comprising a derivative of chitosan and a dendrimer, as well as methods of utilizing the nanoparticle structure.
    Type: Grant
    Filed: July 18, 2016
    Date of Patent: December 13, 2016
    Assignee: PURDUE RESEARCH FOUNDATION
    Inventors: Yoon Yeo, Gaurav Bajaj, Peisheng Xu, Karen Liu, Eun Jung Cho
  • Publication number: 20160346208
    Abstract: The preparation of dual functionalized nanoparticles is generally provided along with their application. The dual functionalized nanoparticles provide dual targeting and can effectively pass the blood brain barrier and target brain tissue. The dual targeted and dual responsive nanoparticles are functionalized to include at least two different ligands that are capable of transport across the blood brain barrier. The nanoparticles can be prepared from polymeric materials that can be biocompatible, provide long circulation life in a body, and be successfully ligated to both functionalities by use of acid-sensitive and/or redox potential-sensitive bonds for delivery across the blood brain barrier and delivery of a payload to brain tissue.
    Type: Application
    Filed: May 26, 2016
    Publication date: December 1, 2016
    Inventors: Peisheng Xu, Eleni Markoutsa
  • Publication number: 20160324886
    Abstract: The present disclosure provides a polymer comprising a derivative of chitosan, wherein the derivative is zwitterionic, as well as methods of using the polymer. In addition, the present disclosure provides a nanoparticle structure comprising a derivative of chitosan and a dendrimer, as well as methods of utilizing the nanoparticle structure.
    Type: Application
    Filed: July 18, 2016
    Publication date: November 10, 2016
    Applicant: Purdue Research Foundation
    Inventors: Yoon YEO, Gaurav BAJAJ, Peisheng XU, Karen LIU, Eun Jung CHO
  • Patent number: 9393262
    Abstract: The present disclosure provides a polymer comprising a derivative of chitosan, wherein the derivative is zwitterionic, as well as methods of using the polymer. In addition, the present disclosure provides a nanoparticle structure comprising a derivative of chitosan and a dendrimer, as well as methods of utilizing the nanoparticle structure.
    Type: Grant
    Filed: September 27, 2012
    Date of Patent: July 19, 2016
    Assignee: PURDUE RESEARCH FOUNDATION
    Inventors: Yoon Yeo, Gaurav Bajaj, Peisheng Xu, Karen Liu, Eun Jung Cho