Patents by Inventor Peixiang Ma

Peixiang Ma has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20250002882
    Abstract: The present invention discloses a Cpf 1 protein and its use in gene editing, which relates to the field of biotechnology. The present invention provides a novel Cas12a nuclease named as the Cas12a-68 protease, which has a wider PAM recognition range than traditional nucleases and is capable of recognizing targets of various genes. When editing nucleic acid fragments, using the new nuclease of the present invention is capable of overcoming the shortcomings of the traditional Cas12a and increasing the PAM recognition range. These advantages make the present invention more suitable for editing a wider range of nucleic acid fragments and lay a foundation for gene editing applications.
    Type: Application
    Filed: May 8, 2024
    Publication date: January 2, 2025
    Inventors: JIN TANG, JUNCHAO SHI, YUANYUAN FENG, PEIXIANG MA, XINGXU HUANG
  • Publication number: 20240229121
    Abstract: The present invention discloses a microRNA detection method and kit for rapid detection of microRNA nucleic acids in biological and environmental samples, including microRNA tailing and a Cpf1 detection system suitable for rapid detection. The present invention is the first to use a combination of microRNA tailing and Cpf1 detection to detect microRNAs, with the advantages of high sensitivity, strong specificity, short time consumption, high throughput, direct interpretation by the naked eye, no dependence on large-scale experimental equipment and the like. These advantages make the detection method developed by the present invention convenient for rapid detection, and identification and diagnosis of microRNAs in biological and environmental samples at a clinical front line.
    Type: Application
    Filed: March 21, 2023
    Publication date: July 11, 2024
    Inventors: PEIXIANG MA, MINGTIAN ZHONG, LU DANG, BAICHENG HUANG
  • Publication number: 20230193408
    Abstract: Disclosed is a nucleic acid test kit, comprising a Cpf1 test system, said Cpf1 test system comprising: a guide RNA, a Cpf1 protein, a nucleic acid probe, and a manganese ion-containing solution. Also provided is a mutated Cpf1 protein and a nucleic acid test kit containing the mutated Cpf1 protein. Also provided is a crRNA for testing coronavirus nucleic acid, and a nucleic acid test kit containing said crRNA. Further provided is a use of the nucleic acid test kit, and a test method for the nucleic acid. When the nucleic acid test kit, mutated Cpf1 protein, or crRNA of the present invention are used for nucleic acid testing (for example, testing the nucleic acid of a SARS-related coronavirus or MERS coronavirus), the signal strength during the test is substantially enhanced, and the test time is thus reduced and the test efficiency improved.
    Type: Application
    Filed: July 16, 2021
    Publication date: June 22, 2023
    Inventors: Peixiang MA, Xinjie WANG
  • Patent number: 11492645
    Abstract: Provided are amino acid sequences capable of binding to and inhibiting a Cas protein's ability to bind to a nucleic acid molecule, thereby inhibiting the Cas protein's function in genome editing. Such Cas protein inhibitors, which can be comprised of a major coat protein (G8P), an extracellular region of the G8P (G8PEX), or a biological equivalent, are useful in improving the specificity of Cas protein-based genome editing procedures.
    Type: Grant
    Filed: August 29, 2019
    Date of Patent: November 8, 2022
    Assignee: ShanghaiTech University
    Inventors: Jia Liu, Biao Jiang, Peixiang Ma, Guang Yang
  • Publication number: 20220213176
    Abstract: The present disclosure provides human antibodies and fragments thereof having binding specificity to the SARS-CoV-2 spike protein's receptor binding domain (RBD). The antibodies and fragments have strong affinity and potent neutralization ability against the SARS-CoV-2 virus and various mutant forms. Also provided are trimeric antibodies which have further enhanced neutralization capabilities. The antibodies and fragments thus may be used for preventing or treating SARS-CoV-2 viral infection or detecting the presence of the virus in a sample.
    Type: Application
    Filed: March 23, 2022
    Publication date: July 7, 2022
    Inventors: Peixiang Ma, Guang Yang, Richard A. Lerner, Min Qiang, Hou Wang
  • Publication number: 20220135629
    Abstract: The present disclosure belongs to the field of biotechnology, and particularly relates to a zinc finger protein-superoxide dismutase fusion protein with a cell membrane penetrating property, and a preparation and an application thereof. A domain of the fusion protein described in the present disclosure comprises a zinc finger protein and superoxide dismutase, and the fusion protein can enter cells to exert an antioxidant activity.
    Type: Application
    Filed: October 30, 2020
    Publication date: May 5, 2022
    Inventors: Jia LIU, Biao JIANG, Peixiang MA
  • Publication number: 20220017471
    Abstract: Disclosed herein are methods of labeling organic compounds without depending on any functional group of the compound. In some embodiments, provided are bifunctional linkers useful in the methods.
    Type: Application
    Filed: July 17, 2019
    Publication date: January 20, 2022
    Inventors: Guang Yang, Richard A. Lerner, Biao Jiang, Peixiang Ma, Hongtao Xu
  • Publication number: 20210317480
    Abstract: Provided are amino acid sequences capable of binding to and inhibiting a Cas protein's ability to bind to a nucleic acid molecule, thereby inhibiting the Cas protein's function in genome editing. Such Cas protein inhibitors, which can be comprised of a major coat protein (G8P), an extracellular region of the G8P (G8PEX), or a biological equivalent, are useful in improving the specificity of Cas protein-based genome editing procedures.
    Type: Application
    Filed: August 29, 2019
    Publication date: October 14, 2021
    Inventors: Jia Liu, Biao Jiang, Peixiang Ma, Guang Yang