Abstract: Disclosed herein is a therapeutics structure containing a motion element, an methotrexate (MTX), N—[N—[(S)-1,3-dicarboxypropyl]carbamoyl]-(S)-lysine (DCL), or UAMC-1110 ligand, and a plurality of drugs selected from the group consisting of camptothecin (CPT), paclitaxel (PTX), podophyllotoxin (PTOX), 7-Ethyl-10-hydroxycamptothecin (SN38), BMS1, BMS8, BMS27, BMS242, LY294002, PI3K-IN-20, and methotrexate (MTX).

Abstract: Disclosed herein are high Tm RNA nanostructures that can be composed of one or more modules or motifs to build RNA nanostructures with or without layers. The RNA nanostructures can have a core domain and three or more double-stranded arms and formulations thereof to conjugate high copy numbers of therapeutics, pH responsive or enzyme cleavable drug cargo. Also described herein is a design strategy for generation of synthetic RNA oligonucleotides that can self assemble into highly thermostable RNA structures. Also described herein are uses of the RNA nanostructures described herein.

Abstract: The presently-disclosed subject matter relates to an artificial RNA nanostructure and method of use thereof. In particular, the presently-disclosed subject matter relates to RNA nanoparticles and RNA dendrimers, and methods of disease diagnosis and treatments using the RNA nanostructure and RNA dendrimers.

Abstract: A method, apparatus, and server for generating a user score based on social networking information is provided. In the disclosed method, by processing circuitry of an information processing apparatus, default annotation information of a plurality of sampled users, an ith user score and an ith relative user score for each of the sampled users are obtained. A user score model is trained according to the ith user score of the respective sampled user, the ith relative user score of the respective sampled user, and the default annotation information of the respective sampled user. An (i+1)th user score of the respective sampled user is subsequently calculated and a trained user score model, for each of the sampled users, is obtained when the (i+1)th user score for the respective sampled user satisfies a training termination condition, The method provides a solution to evaluate the user score for a use when personal information of the user is missing or incorrect.

Abstract: An integrated photonics millimeter wave (MMW) radar communication system based on analog phase modulation scheme includes an integrated photonics MMW radar communication signal transmitter, a radar receiver, and a communication receiver. The transmitter includes a radar communication signal analog phase modulation module, an optical frequency comb (OFC) module, an electro-optic modulator (EOM), an optical shaping filter, an optical power divider, a photoelectric detector, an electric power amplifier, and a transmitting antenna that are cascaded sequentially. The radar receiver includes a radar receiving antenna, an electric low-noise amplifier (LNA), an optical phase modulator, an optical bandpass filter (BPF), a low-speed photoelectric detector, an electric low-pass filter, and a low-speed oscilloscope that are cascaded sequentially.

Abstract: A radio-over-fiber communication beamforming device based on arrayed waveguide grating and a method thereof. The radio frequency signal is modulated onto a plurality of optical carriers of different wavelengths and processed by a programmable photonic true-time delay module in the optical domain. The programmable photonic true-time delay module includes optical switches and a plurality of cascaded AWGs which can provide different basic delays between adjacent wavelength channels. The basic delays of different stages of the AWG present a geometric sequence with a common ratio of 2. Optical carriers of different wavelengths enter different branches and undergo photoelectric conversion to obtain the radio frequency signals of different delays (phases) to realize a far-field beam directional radiation pattern.