Patents by Inventor Peiyu ZHANG

Peiyu ZHANG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240183747
    Abstract: A rapid detection tool for a coaxial relationship based on a photosensitive material and a detection method using the same are used to detect coaxiality of two through-holes in the same workpiece to be detected. An image processing unit and a control unit are mounted outside a light-shielding box. Light sources, cameras, sensors, and an air cylinder are mounted in the light-shielding box. A photosensitive plate coated with a photosensitive resin is placed between the two holes, and two sides are irradiated by the light sources. Coordinates of centers of circular patterns formed on the photosensitive plate are calculated so that a coaxial relationship between the two holes can be accurately obtained. An output rod of the air cylinder is controlled to extend outward to reject a workpiece to be detected not meeting requirements.
    Type: Application
    Filed: February 25, 2022
    Publication date: June 6, 2024
    Applicant: JIANGSU UNIVERSITY
    Inventors: Yun WANG, Lihui REN, Fuzhu LI, Zhenying XU, Kun ZHANG, Wang NI, Ying YAN, Weili LIU, Peiyu HE, Xu DING
  • Publication number: 20240166617
    Abstract: The invention provides novel phosphoinositide 3 kinase beta-selective inhibitors and pharmaceutical compositions thereof, as well as methods of their preparation and use, in therapy of various diseases and conditions, such as solid tumors.
    Type: Application
    Filed: January 25, 2022
    Publication date: May 23, 2024
    Inventors: Jean Zhao, Qi Wang, Xiang Y. Yu, Huimin Cheng, Peiyu Zhang, Zhixiong Lin, Lei Fang, Songling Ma
  • Publication number: 20240169592
    Abstract: Disclosed are a gated network-based generator, a generator training method, and a method for avoiding image coordinate adhesion. The generator processes, by using an image input layer, a to-be-processed image as an image sequence and inputs it to a feature encoding layer. Multiple feature encoding layers encode the image sequence by using a gated convolutional network, to obtain an image code. Moreover, multiple image decoding layers decode the image code by using an inverse gated convolution unit, to obtain a target image sequence. Finally, an image output layer splices the target image sequence to obtain a target image. Therefore, a character feature in the obtained target image is more obvious, making details of a facial image of generated digital human more vivid, whereby solving a problem of image coordinate adhesion in a digital human image generated by an existing generator using a generative adversarial network, and improving user experience.
    Type: Application
    Filed: June 29, 2023
    Publication date: May 23, 2024
    Applicant: NANJING SILICON INTELLIGENCE TECHNOLOGY CO., LTD.
    Inventors: Huapeng SIMA, Maolin ZHANG, Peiyu WANG
  • Patent number: 11853663
    Abstract: The disclosure provides an efficient Monte Carlo molecular simulation method for calculating the liquid phase interfacial tension between benzene and water by improving Ewald sum, including the following steps: Step A: Initialize the simulation: two simulation boxes were prepared, both with the size (30×30×45 ?)-(35×35×55 ?), and 1200-2000 water molecules and 230-380 benzene molecules were respectively put on the grid point of the two boxes; Step B: Select the force field used for simulation; Step C: Perform Monte Carlo simulations on the two boxes separately under the canonical ensemble; Step D: Join the water box and the benzene box along the z direction to form a large box of (30×30×90 ?)-(35×35×110 ?), and run 50000-80000 Monte Carlo cycles to make the system reach equilibrium; Step E: After the system reaches equilibrium, the data was collected during the production period.
    Type: Grant
    Filed: October 17, 2019
    Date of Patent: December 26, 2023
    Assignee: SHENZHEN JINGTAI TECHNOLOGY CO., LTD.
    Inventors: Bai Xue, Jian Ma, Lipeng Lai, Shuhao Wen, Peiyu Zhang
  • Publication number: 20230399339
    Abstract: The present disclosure relates to a heterocyclic amide derivative, a preparation method therefor and an application thereof. Specifically, the present disclosure relates to a compound of formula I, a preparation method therefor and an application thereof, a pharmaceutical composition containing the compound as an active ingredient, or a pharmaceutically acceptable salt thereof. The present disclosure further relates to a use of the compound of formula (I) in the treatment and prevention of EP4-mediated diseases.
    Type: Application
    Filed: January 27, 2022
    Publication date: December 14, 2023
    Inventors: Huimin CHENG, Xiaoming WEN, Peiyu ZHANG, Zhiqiang LIU, Lan LUO, Lipeng LAI, Jian MA, Shuhao WEN
  • Publication number: 20230219979
    Abstract: Disclosed are a pyrazolo[1,5-a]pyridine compound, a preparation method therefor and a use thereof. Also disclosed is a pharmaceutical composition containing the compound as an active ingredient or a pharmaceutically acceptable salt thereof. The present invention further relates to the use of a compound of formula (I) for treating and preventing diseases that can be treated with wild-type, gene fusion-type and mutant (including but not limited to G804 and G810) RET kinase inhibitors, including diseases or conditions mediated by an RET kinase.
    Type: Application
    Filed: December 11, 2020
    Publication date: July 13, 2023
    Applicant: SHENZHEN ZHONGGE BIOLOGICAL TECHNOLOGY CO., LTD.
    Inventors: Huimin CHENG, Lei FANG, Xiaoming WEN, Zhiqiang LIU, Yu CHEN, Songling MA, Ping CHEN, Zhenzhen QI, Chunyi NIU, Peiyu ZHANG, Lipeng LAI, Jian MA, Shuhao WEN
  • Publication number: 20230159523
    Abstract: The present invention relates to a pyrazolo[1,5-a]pyridine derivative, a preparation method therefor, and a composition and a use thereof. Specifically, the present invention relates to the compound of formula (I) and the use thereof for the treatment and/or prevention of wild type, gene-fusion type (including but not limited to KIF5B, CCDC6 and NCOA4) and mutant type (including but not limited to V804, G810 and M918) RET kinases-related diseases, including diseases or conditions mediated by RET kinase.
    Type: Application
    Filed: April 22, 2021
    Publication date: May 25, 2023
    Applicant: SHENZHEN ZHONGGE BIOLOGICAL TECHNOLOGY CO., LTD.
    Inventors: Huimin CHENG, Xiaoming WEN, Zhiqiang LIU, Lei FANG, Yu CHEN, Yong WEI, Guogang ZHANG, Chuansheng LI, Songling MA, Zhenzhen QI, Ping CHEN, Chunyi NIU, Peiyu ZHANG, Lipeng LAI, Jian MA, Shuhao WEN
  • Patent number: 11562806
    Abstract: The invention belongs to the technical field of drug crystal analysis, and particularly relates to a drug crystal structure landscape analysis system and a landscape analysis method thereof. The drug crystal structure landscape analysis system calls a cloud computing interface to calculate the energy of input crystals through an algorithm deployed in the cloud in advance, and an energy-density space group landscape array diagram of the crystals is generated according to the computation results returned; and analysis is selectively carried out as needed, result reports arc analyzed and summarized as a final report, and the final report is converted into a text document. The drug crystal structure landscape analysis system and the landscape analysis method thereof satisfy the drug crystal structure analysis requirements in the new technology background, and can analyze a large quantity of crystals which are formed by a certain drug molecule and have different structures.
    Type: Grant
    Filed: May 9, 2018
    Date of Patent: January 24, 2023
    Assignee: SHENZHEN JINGTAI TECHNOLOGY CO., LTD.
    Inventors: Xuekun Shi, Yongpan Chen, Yang Liu, Peiyu Zhang, Jian Ma, Lipeng Lai, Shuhao Wen
  • Patent number: 11443834
    Abstract: The invention relates to an automatic conformation analysis method for quasi-drug organic molecules. The method includes: extracting a group of fragments from an input molecule, wherein there are primarily three types of fragments: a flexible bond fragment, a ring isomerism fragment and a conformation isomerism fragment; carrying out knowledge-based conformation recommendation; carrying out conformation recommendation based on force field scanning; verifying, by QM, the generated conformations, wherein if the verification succeeds, it indicates that the recommended conformations are valid; or otherwise, the force field is corrected; collecting conformation lists of the fragments; and combining and optimizing conformation parameters of the fragments through a genetic algorithm, and finding out a set of optimal conformations. The invention integrates the advantages of a knowledge-based method and the advantages of a computation method, so that accurate conformation recommendations can be acquired.
    Type: Grant
    Filed: May 9, 2018
    Date of Patent: September 13, 2022
    Assignee: SHENZHEN JINGTAI TECHNOLOGY CO., LTD.
    Inventors: Yang Liu, Peiyu Zhang, Mingjun Yang, Guangxu Sun, Jian Ma, Lipeng Lai, Shuhao Wen
  • Publication number: 20220130487
    Abstract: The present invention provides a drug virtual screening system for crystal complexes, and method of using the same, comprising a visualization subsystem, an evaluation tool box subsystem, an AI model management subsystem, a large-scale sampling subsystem, a virtual screening subsystem, and a data log storage subsystem. Starting with the known crystal complexes, a batch of candidate compounds that meet the requirements are recommended after going through the visualization subsystem, evaluation tool box subsystem, AI model management subsystem, large-scale sampling subsystem, and virtual screening system in turn. Based on this system, the generation of the compound library is organically combined with the subsequent virtual screening. Users only need to describe the action mode of the drug on the protein and the requirements for the drug to generate a batch of compounds that meet the expectations. The automated system reduces user intervention and improves the efficiency of research and development.
    Type: Application
    Filed: June 28, 2020
    Publication date: April 28, 2022
    Applicant: SHENZHEN JINGTAI TECHNOLOGY CO., LTD.
    Inventors: Lijun YANG, Min XU, Peiyu ZHANG, Jian MA, Shuhao WEN, Lipeng LAI
  • Publication number: 20210375402
    Abstract: The invention pertains to the field of organic molecular crystal structure prediction, and particularly related to a double-layer neural network algorithm for high-precision energy calculation of organic molecular crystal structure, including the first round of conventional crystal structure prediction; extract all molecular conformations from existing crystals and calculate their energies; extract all molecular dimers within the Van der Waals radius of the central unit cell and calculate the intermolecular interaction energies; perform molecular conformation analysis to build a convolutional neural network of single-molecule conformational energies; build a molecular dimer energy-corrected convolutional neural network; calculate the total crystal energies.
    Type: Application
    Filed: September 5, 2019
    Publication date: December 2, 2021
    Applicant: SHENZHEN JINGTAI TECHNOLOGY CO., LTD.
    Inventors: Yingdi JIN, Peiyu ZHANG, Qun ZENG, Guangxu SUN, Lipeng LAI, Jian MA, Shuhao WEN
  • Publication number: 20210365618
    Abstract: The disclosure provides an efficient Monte Carlo molecular simulation method for calculating the liquid phase interfacial tension between benzene and water by improving Ewald sum, including the following steps: Step A: Initialize the simulation: two simulation boxes were prepared, both with the size (30×30×45 ?)-(35×35×55 ?), and 1200-2000 water molecules and 230-380 benzene molecules were respectively put on the grid point of the two boxes; Step B: Select the force field used for simulation; Step C: Perform Monte Carlo simulations on the two boxes separately under the canonical ensemble; Step D: Join the water box and the benzene box along the z direction to form a large box of (30×30×90 ?)-(35×35×110 ?), and run 50000-80000 Monte Carlo cycles to make the system reach equilibrium; Step E: After the system reaches equilibrium, the data was collected during the production period.
    Type: Application
    Filed: October 17, 2019
    Publication date: November 25, 2021
    Applicant: SHENZHEN JINGTAI TECHNOLOGY CO., LTD.
    Inventors: Bai XUE, Jian MA, Lipeng LAI, Shuhao WEN, Peiyu ZHANG
  • Publication number: 20210265020
    Abstract: A high-precision energy ranking method used for the crystal structure prediction of organic molecules, including: determining a quantum mechanical radius of a center cell; carrying out an energy calculation in the center cell through a density fragment interaction algorithm; calculating an interaction energy of the molecules outside the center cell acting on the molecules in the center cell within the radius R under quantum mechanical precision; calculating an interaction energy of peripheral extension cells beyond the radius R acting on the molecules in the center cell under molecular mechanical precision; and calculating a total crystal energy.
    Type: Application
    Filed: May 4, 2018
    Publication date: August 26, 2021
    Applicant: SHENZHEN JINGTAI TECHNOLOGY CO., LTD.
    Inventors: Yingdi JIN, Qun ZENG, Peiyu ZHANG, Jian MA, Lipeng LAI, Shuhao WEN
  • Publication number: 20210265022
    Abstract: The invention belongs to the technical field of drug crystal analysis, and particularly relates to a drug crystal structure landscape analysis system and a landscape analysis method thereof. The drug crystal structure landscape analysis system calls a cloud computing interface to calculate the energy of input crystals through an algorithm deployed in the cloud in advance, and an energy-density space group landscape array diagram of the crystals is generated according to the computation results returned; and analysis is selectively carried out as needed, result reports arc analyzed and summarized as a final report, and the final report is converted into a text document. The drug crystal structure landscape analysis system and the landscape analysis method thereof satisfy the drug crystal structure analysis requirements in the new technology background, and can analyze a large quantity of crystals which are formed by a certain drug molecule and have different structures.
    Type: Application
    Filed: May 9, 2018
    Publication date: August 26, 2021
    Applicant: SHENZHEN JINGTAI TECHNOLOGY CO., LTD.
    Inventors: Xuekun SHI, Yongpan CHEN, Yang LIU, Peiyu ZHANG, Jian MA, Lipeng LAI, Shuhao WEN
  • Publication number: 20210265019
    Abstract: The invention relates to an automatic conformation analysis method for quasi-drug organic molecules. The method includes: extracting a group of fragments from an input molecule, wherein there are primarily three types of fragments: a flexible bond fragment, a ring isomerism fragment and a conformation isomerism fragment; carrying out knowledge-based conformation recommendation; carrying out conformation recommendation based on force field scanning; verifying, by QM, the generated conformations, wherein if the verification succeeds, it indicates that the recommended conformations are valid; or otherwise, the force field is corrected; collecting conformation lists of the fragments; and combining and optimizing conformation parameters of the fragments through a genetic algorithm, and finding out a set of optimal conformations. The invention integrates the advantages of a knowledge-based method and the advantages of a computation method, so that accurate conformation recommendations can be acquired.
    Type: Application
    Filed: May 9, 2018
    Publication date: August 26, 2021
    Applicant: SHENZHEN JINGTAI TECHNOLOGY CO., LTD.
    Inventors: Yang LIU, Peiyu ZHANG, Mingjun YANG, Guangxu SUN, Jian MA, Lipeng LAI, Shuhao WEN
  • Patent number: 11093685
    Abstract: The invention belongs to the technical field force fields and particularly provides an atom type definition system and an atom type matching method. The atom type definition system includes an atom type visual UI interface, an atom type matching module, an atom type data management module and an atom type format transformation module. The atom type data management module includes an atom type definition data package. The system and method can describe various complicated atomic chemical environments, the description capability is improved, and the computation of a force field can be more accurate. According to the invention, convenient operation on an atom type can be realized, and addition, deletion, modification, inquiry as well as statistics of multiple dimensions are very visual and convenient.
    Type: Grant
    Filed: May 4, 2018
    Date of Patent: August 17, 2021
    Assignee: SHENZHEN JINGTAI TECHNOLOGY CO., LTD.
    Inventors: Xuekun Shi, Fenglei Cao, Mingjun Yang, Guangxu Sun, Peiyu Zhang, Jian Ma, Lipeng Lai, Shuhao Wen
  • Patent number: 11014890
    Abstract: Forms B and C of (R)—N-(4-chlorophenyl)-2-(cis-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide are stable under the conditions of light, high temperature and high humidity.
    Type: Grant
    Filed: May 3, 2019
    Date of Patent: May 25, 2021
    Assignee: SHENZHEN RENTAI PHARMATECH LTD
    Inventors: Dongxu Yi, Guobin Ren, Jian Ma, Shuhao Wen, Peiyu Zhang, Yang Liu, Xuekun Shi, Jiajun Huang, Yanqi Zhang, Shigang Ruan, Mingjun Yang, Guangxu Sun
  • Patent number: 10978177
    Abstract: A method for automatically and efficiently fitting repulsive potentials through DFTB includes: optimizing a molecule containing an atomic pair, and performing spacing scan on the atomic pair according to an acting interval of repulsive potentials; performing high-accuracy energy calculation on a scanning result; performing difference calculation on obtained energy to obtain second-order derivatives of force and energy; saving a structure, the energy, the second-order derivatives of force and energy into a database; acquiring energy without a repulsive potential as well as the second-order derivatives of force and energy to obtain target values of the repulsive potentials; transforming the separated target values of the repulsive potentials into splines; splicing multiple splines on a mean position between equilibrium position points to obtain new train data; constructing a train set by means of necessary samples and choosable samples; and fitting the repulsive potentials through singular value decomposition.
    Type: Grant
    Filed: May 11, 2018
    Date of Patent: April 13, 2021
    Assignee: SHENZHEN JINGTAI TECHNOLOGY CO., LTD.
    Inventors: Qun Zeng, Peiyu Zhang, Yingdi Jin, Jian Ma, Lipeng Lai, Shuhao Wen
  • Publication number: 20200342159
    Abstract: The invention belongs to the technical field force fields and particularly provides an atom type definition system and an atom type matching method. The atom type definition system includes an atom type visual UI interface, an atom type matching module, an atom type data management module and an atom type format transformation module. The atom type data management module includes an atom type definition data package. The system and method can describe various complicated atomic chemical environments, the description capability is improved, and the computation of a force field can be more accurate. According to the invention, convenient operation on an atom type can be realized, and addition, deletion, modification, inquiry as well as statistics of multiple dimensions are very visual and convenient.
    Type: Application
    Filed: May 4, 2018
    Publication date: October 29, 2020
    Applicant: SHENZHEN JINGTAI TECHNOLOGY CO., LTD.
    Inventors: Xuekun SHI, Fenglei CAO, Mingjun YANG, Guangxu SUN, Peiyu ZHANG, Jian MA, Lipeng LAI, Shuhao WEN
  • Patent number: 10817532
    Abstract: The invention provides a scientific computing process management system. The system includes a basic data presentation layer for storing and presenting business models, a case service module for providing addition, deletion, checking, and changing as well as task submission and data analysis triggering of a case contained in an interface, computing service modules released as a packaged based image and called through a task scheduling system, a resource statistic service module for providing computing resource consumptions statistics accurate to a task level, a persistent layer for persisting data, an audit module for performing audit work on universal data changes and performing backtracking when data is in an unexpected state, a real-time sync module for performing data synchronization in real time together with the task scheduling system, an async communication module for processing computing service communication and an async analysis module for performing analysis in a pushing process of a case.
    Type: Grant
    Filed: May 10, 2018
    Date of Patent: October 27, 2020
    Assignee: SHENZHEN JINGTAI TECHNOLOGY CO., LTD.
    Inventors: Yan Wang, Xuekun Shi, Yang Liu, Peiyu Zhang, Jian Ma, Lipeng Lai, Shuhao Wen