Abstract: The invention provides a method and system of separating and locating a plurality of acoustic sources in a human body. The system includes a plurality of sensors, a processing unit and an output device. The method includes recording a plurality of signals by utilizing the plurality of sensors, wherein the plurality of sensors are arranged about one or more portions of the human body. A signal processing technique is applied for separating a plurality of sets of statistically independent sounds from the plurality of signals. Thereafter, a correlation technique is applied on the plurality of sets of statistically independent sounds to obtain a plurality of sets of reference signal dependent sounds. Finally, an advance acoustic location technique is applied on each of the plurality of sets of reference signal dependent sounds to locate the plurality of acoustic signal sources.