Patents by Inventor Penchit Chitnumsub

Penchit Chitnumsub has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Anti-folate antimalarials with dual-binding modes and their preparation
    Patent number: 9000003
    Abstract: The present invention is anti-folate antimalarials with dual-binding modes of the general formula (I) [refer to structure in the abstract] wherein R1 and R2 which may be the same or different are independently selected from methyl or ethyl or alkylphenyl, R3 is independently hydrogen, halide, lower alkyl substituted with ester, carboxylic, amide, and ether. Linker is X(CH2)nY wherein X and Y which may be the same or different are independently selected from oxygen, carbon, nitrogen, substituted phenyl where n is an integer from 1 to 2-6, or pharmaceutically acceptable salts therefore. The anti-folate antimalarials with dual-binding modes act as novel inhibitors with good inhibition constants against wild-type, double (C59R+SIOSN), triple (N51+C59R+SIOSN, C59R+S 1 OSN+I164L), and quadruple (N51+C59R+S108N+I164L) mutant enzymes. The compounds are also effective against wild type (Tm4/S.2) and mutants (K1CB1, W2, Cs1-2 and V1/S) malaria parasites.
    Type: Grant
    Filed: February 9, 2012
    Date of Patent: April 7, 2015
    Assignee: National Science and Technology Development Agency
    Inventors: Bongkoch Tarnchompoo, Penchit Chitnumsub, Sumalee Kamchonwongpaisan, Philip James Shaw, Roonglawan Rattanajak, Sinothai Poen, Tosapol Anukunwithaya, Chayaphat Wongsombat, Yongyuth Yuthavong
  • ANTI-FOLATE ANTIMALARIALS WITH DUAL-BINDING MODES AND THEIR PREPARATION
    Publication number: 20130324727
    Abstract: The present invention is anti-folate antimalarials with dual-binding modes of the general formula (I) [refer to structure in the abstract] wherein R1 and R2 which may be the same or different are independently selected from methyl or ethyl or alkyl-phenyl, R3 is independently hydrogen, halide, lower alkyl substituted with ester, carboxylic, amide, and ether. Linker is X(CH2)nY wherein X and Y which may be the same or different are independently selected from oxygen, carbon, nitrogen, substituted phenyl where n is an integer from 1 to 2-6, or pharmaceutically acceptable salts therefore. The anti-folate antimalarials with dual-binding modes act as novel inhibitors with good inhibition constants against wild-type, double (C59R+SIOSN), triple (N51+C59R+SIOSN, C59R+S 1 OSN+I164L), and quadruple (N51+C59R+S108N+I164L) mutant enzymes. The compounds are also effective against wild type (Tm4/S.2) and mutants (K1CB1, W2, Cs1-2 and V1/S) malaria parasites.
    Type: Application
    Filed: February 9, 2012
    Publication date: December 5, 2013
    Applicant: National Science and Techology Development Agency
    Inventors: Bongkoch Tarnchompoo, Penchit Chitnumsub, Sumalee Kamchonwongpaisan, Philip James Shaw, Roonglawan Rattanajak, Sinothai Poen, Tosapol Anukunwithaya, Chayaphat Wongsombat, Yongyuth Yuthavong
  • Antimalarial compounds with flexible side-chains
    Patent number: 8530491
    Abstract: The present invention relates to novel compounds that are inhibitors of wild type and mutant dihydrofolate reductase (DHFR) of Plasmodium falciparum, which are useful for the treatment of malaria. It also relates to processes of making and using such compounds. The antimalarial compounds of the present invention have low toxicity to a host infected with the malarial parasite, and are potent when administered in pharmaceutical compositions.
    Type: Grant
    Filed: October 8, 2008
    Date of Patent: September 10, 2013
    Assignee: Medicines for Malaria Venture (MMV)
    Inventors: Yongyuth Yuthavong, Tirayut Vilaivan, Sumalee Kamchonwongpaisan, Bongkoch Tarnchompoo, Chawanee Thongpanchang, Penchit Chitnumsub, Jirundon Yuvaniyama, David Matthews, William Charman, Susan Charman, Livia Vivas, Sanjay Babu Katiyar
  • ANTIMALARIAL COMPOUNDS WITH FLEXIBLE SIDE-CHAINS
    Publication number: 20090099220
    Abstract: The present invention relates to novel compounds that are inhibitors of wild type and mutant dihydrofolate reductase (DHFR) of Plasmodium falciparum, which are useful for the treatment of malaria. It also relates to processes of making and using such compounds. The antimalarial compounds of the present invention have low toxicity to a host infected with the malarial parasite, and are potent when administered in pharmaceutical compositions.
    Type: Application
    Filed: October 8, 2008
    Publication date: April 16, 2009
    Inventors: Yongyuth YUTHAVONG, Tirayut Vilaivan, Sumalee Kamchonwongpaisan, Bongkoch Tarnchompoo, Chawanee Thongpanchang, Penchit Chitnumsub, Jirundon Yuvaniyama, David Matthews, William Charman, Susan Charman, Livia Vivas, Sanjay Babu Katiyar