Abstract: A numerical simulation method of a disaster chain from landslide and surge wave to glacier lake outburst, including: obtaining simulation data required by a numerical simulation algorithm based on a depth-averaged mixed flow model coupling a continuum mechanics algorithm with a mixed flow. The simulation data includes at least one of topographic data, location of landslide initiation, volume and depth information of the landslide initiation, coarse particles content and fine particles content in an initial stage of the landslide, a friction angle between the landslide and a bed, coarse particles content and fine particles content of the landslide in an erodible channel, water depth distribution of the glacier lake, a bed roughness coefficient of surge and flood evolution, coarse particles content and fine particles content in a moraine dam, and characteristic particle size of the coarse particles and the fine particles in the moraine dam.

Abstract: Disclosed is a numerical simulation method for rainfall-induced flash flood and debris flow, including: obtaining, based on a continuum medium mechanics manner coupled with a hydrodynamic model of a three-phase medium of water, coarse particles, and fine particles, data required for the numerical simulation method. The present disclosure is based on a theory of continuum mechanics, which realizes the numerical simulation method for the flash flood and debris flow considering rainfall conditions by a finite difference manner based on the continuum medium mechanics manner coupled with the hydrodynamic model of the three-phase medium of the water, the coarse particles, and the fine particles. The method in the present disclosure is able to simulate formation, movement, and sediment transport processes of the flash flood and debris flow under different rainfall condition.

Abstract: A method for training a lane line detection model includes (i) obtaining a dataset comprising a plurality of road image samples, wherein the road image samples have lane line labels, (ii) extracting lane line feature vectors of the road image samples by way of an image segmentation model and the lane line labels of the road image samples, (iii) determining the lane line detection difficulty of the road image samples based on the lane line feature vectors of the road image samples, and (iv) training the lane line detection model using the road image samples in the dataset and a loss function based on the lane line detection difficulty of the road image samples.

Abstract: Six-membered high-entropy foam for hydrogen production by water splitting and preparation method are provided. The foam consists of Ni, Fe, Cu, Co, Mo, and Pt, comprising 10 at %-25 at % of Ni, 10 at %-25 at % of Fe, 10 at %-25 at % of Cu, 10 at %-25 at % of Co, 10 at %-25 at % of Mo, and 10 at %-25 at % of Pt. Catalyst loading of the foam can reach a range of 0.8 mg/cm2-3.2 mg/cm2, which is much higher than the effective catalyst loading of most nano-catalysts. When used as catalyst for hydrogen production by water splitting, the hydrogen evolution overpotential of the surface of the six-membered high-entropy foam is within a range of 36 mV-60 mV, and the foam operates stably at industrial-level current density (500 mA/cm2). The preparation method does not require harsh environment such as high temperature or high vacuum, making the method simple and easy to implement, with low-cost raw materials.

Abstract: Provided is an isolated binding protein including an antigen binding domain binding to an NS1 protein, and comprising specific heavy chain CDR and light chain CDR. The binding protein can specifically identify and bind to NS1, and has relatively high sensitivity and specificity, so as to detect dengue virus. Moreover, the binding protein does not need to be produced by injecting hybridoma cells into mouse peritoneal cavity, while simplifying production, thus stabilizing antibody functionality.

Abstract: Embodiments of the present disclosure are directed to charge variants of a protein such as vascular endothelial growth factor VEGF-Trap, and methods, systems, devices and kits corresponding to methods for analyzing the same.

Abstract: Provided are an isolated binding protein including an antigen binding domain of cardiac troponin I (cTnI), as well as a preparation and uses of the binding protein. The antigen binding domain includes at least one complementary determining region selected from the amino acid sequences defined herein; or the antigen-binding domain has at least 80% sequence identity with the complementary determining regions of said amino acid sequences and has an affinity for cardiac troponin I of KD?3.33×10?8 mo/L. The binding protein may be used in the field of cTnI protein detection.

Abstract: Provided is an isolated binding protein including an antigen-binding domain that binds to NS1 protein. The isolated binding protein includes specific heavy chain CDRs and light chain CDRs. The binding protein can specifically recognize and bind to NS1, and has relatively high sensitivity and specificity, thereby achieving the detection of dengue virus. Moreover, the binding protein is not required to be produced by inducing hybridoma cells in mouse abdominal cavity, and thus it is simple in production and has more stable antibody function.

Abstract: Provided is an isolated binding protein including an antigen binding domain binding to an NS1 protein, and including specific heavy chain CDR and light chain CDR. The binding protein can specifically identify and bind to NS1, and has relatively high sensitivity and specificity, so as to detect dengue vims. Moreover, the binding protein does not need to be produced by injecting hybridoma cells into mouse peritoneal cavity, while simplifying production, thus stabilizing antibody functionality.

Abstract: Six-membered high-entropy foam for hydrogen production by water splitting and preparation method are provided. The foam consists of Ni, Fe, Cu, Co, Mo, and Pt, comprising 10 at %-25 at % of Ni, 10 at %-25 at % of Fe, 10 at %-25 at % of Cu, 10 at %-25 at % of Co, 10 at %-25 at % of Mo, and 10 at %-25 at % of Pt. Catalyst loading of the foam can reach a range of 0.8 mg/cm2-3.2 mg/cm2, which is much higher than the effective catalyst loading of most nano-catalysts. When used as catalyst for hydrogen production by water splitting, the hydrogen evolution overpotential of the surface of the six-membered high-entropy foam is within a range of 36 mV-60 mV, and the foam operates stably at industrial-level current density (500 mA/cm2). The preparation method does not require harsh environment such as high temperature or high vacuum, making the method simple and easy to implement, with low-cost raw materials.

Abstract: Disclosed is an isolated binding protein including a cardiac troponin I (cTnI) antigen binding domain, and preparation and a use and the like of the binding protein. The antigen binding domain includes at least one complementarity determining region selected from an amino acid sequence defined in this article, or has at least 80% sequence identity with the complementarity determining region of the amino acid sequence and has KD?9.96×10?8 mol/L affinity with cTnI. The binding protein may be used in the detection field of the cTnI protein.

Abstract: The present disclosure relates to the field of medical diagnosis, and specifically, relates to a synthetic peptide for detecting HIV-1. The synthetic peptide is obtained by mutating the amino acid sequence set forth as SEQ ID NO: 1. The synthetic peptide can better detect anti-HIV-1 antibodies, and can better avoid potential “false negative” and “false positive” results.

Abstract: The method for preventing and controlling glacial lake outbreak flood and related debris flows by the present invention is mainly controlling the scale of the floods by separating water and rocks and dispersing its energy step by step. The cascading amplification effects of floods can be reduced by controlling the initiation of source material with energy dissipation by using ground sills, groups of piles, and placed large stones and prefabricated artificial structures. The diversion dam built in the downstream area discharge floods in different layers, which can quickly guide water to the main river. The preconstructed engineering system can be used in a timely manner to prevent and control floods and debris flows induced by a sudden outburst of glacial lakes in areas with important facilities and inhabitants enduring the risk of natural hazards. Prevention and control systems can separate floods and debris flows and dissipate their energy.

Abstract: Provided is an isolated binding protein including an antigen binding domain binding to an NS1 protein, and comprising specific heavy chain CDR and light chain CDR. The binding protein can specifically identify and bind to NS1, and has relatively high sensitivity and specificity, so as to detect dengue virus. Moreover, the binding protein does not need to be produced by injecting hybridoma cells into mouse peritoneal cavity, while simplifying production, thus stabilizing antibody functionality.