Abstract: The present disclosure relates to pharmaceutical formulations comprising heterodimeric Relaxin fusion polypeptides, in particular heterodimeric Relaxin 2 fusion polypeptides and uses thereof. Thus, the disclosure provides pharmaceutical formulations comprising Relaxin fusion polypeptides and kits comprising the same and uses of the same including methods of treatment. The pharmaceutical formulations of the disclosure may be useful, in particular, in the treatment of cardiovascular diseases, for example for the treatment of heart failure.

Abstract: A computer-implemented method for Li-plating detection of a cell of a power battery. The method includes: obtaining a plurality of AC impedance values for the cell measured at a plurality of States of Charge (SOCs), in which the plurality of AC impedance values are measured in a non-driving state of a vehicle; fitting the AC impedance values as a function of SOC based on the plurality of AC impedance values; and calculating a goodness of fit for the function, and calculating a Li-plating score for the cell based on the goodness of fit, in which the Li-plating score is used to indicate a degree to which Li-plating occurs in the cell.

Abstract: The present invention relates to heterodimeric Relaxin fusion polypeptides, in particular to heterodimeric Relaxin 2 fusion polypeptides and uses thereof. Thus, the invention provides Relaxin fusion polypeptides, nucleic acid molecules, vectors, host cells, pharmaceutical compositions and kits comprising the same and uses of the same including methods of treatment. The polypeptides and compositions of the invention may be useful, in particular, in the treatment of cardiovascular diseases, for example for the treatment of heart failure.

Abstract: A method, an apparatus and device, and a computer-readable storage medium for detecting Li-plating in a lithium battery. The method for detecting Li-plating in a lithium battery includes: charging and discharging the lithium battery to be detected at a preset current, and collecting correlation parameters of the lithium battery during the charging and discharging; acquiring a current number of charge-discharge cycles of the lithium battery; calculating a plurality of detection scores for detecting whether there is Li-plating in the lithium battery based on the current number of charge-discharge cycles and the correlation parameters; and determining a fused detection score based on the plurality of detection scores, and determining that there is Li-plating in the lithium battery if the fused detection score exceeds a fused detection threshold.

Abstract: The present invention relates to heterodimeric Relaxin fusion polypeptides, in particular to heterodimeric Relaxin 2 fusion polypeptides and uses thereof. Thus, the invention provides Relaxin fusion polypeptides, nucleic acid molecules, vectors, host cells, pharmaceutical compositions and kits comprising the same and uses of the same including methods of treatment. The polypeptides and compositions of the invention may be useful, in particular, in the treatment of cardiovascular diseases, for example for the treatment of heart failure.

Abstract: The present invention relates to heterodimeric Relaxin fusion polypeptides, in particular to heterodimeric Relaxin 2 fusion polypeptides and uses thereof. Thus, the invention provides Relaxin fusion polypeptides, nucleic acid molecules, vectors, host cells, pharmaceutical compositions and kits comprising the same and uses of the same including methods of treatment. The polypeptides and compositions of the invention may be useful, in particular, in the treatment of cardiovascular diseases, for example for the treatment of heart failure.

Abstract: Described herein are stable pharmaceutical formulations for bioactive agents, including macromolecular bioactive agents such as polynucleotides and polypeptides. Also provided are medicaments and treatments using the pharmaceutical formulations described herein, as well as kits and methods of treating, preventing or managing a disease or disorder using the pharmaceutical formulations described herein.

Abstract: The present invention relates to heterodimeric Relaxin fusion polypeptides, in particular to heterodimeric Relaxin 2 fusion polypeptides and uses thereof. Thus, the invention provides Relaxin fusion polypeptides, nucleic acid molecules, vectors, host cells, pharmaceutical compositions and kits comprising the same and uses of the same including methods of treatment. The polypeptides and compositions of the invention may be useful, in particular, in the treatment of cardiovascular diseases, for example for the treatment of heart failure.

Abstract: The present invention relates to heterodimeric Relaxin fusion polypeptides, in particular to heterodimeric Relaxin 2 fusion polypeptides and uses thereof. Thus, the invention provides Relaxin fusion polypeptides, nucleic acid molecules, vectors, host cells, pharmaceutical compositions and kits comprising the same and uses of the same including methods of treatment. The polypeptides and compositions of the invention may be useful, in particular, in the treatment of cardiovascular diseases, for example for the treatment of heart failure.

Abstract: Provided are picture encoding and decoding methods and apparatuses, and a picture encoding and decoding system. The picture encoding method includes: determining an adjustment factor according to pixel sampling values of a video picture; converting the video picture according to the adjustment factor, and encoding the converted video picture; and writing the adjustment factor into a bitstream obtained by encoding the converted video picture.

Abstract: Provided are picture encoding and decoding methods and apparatuses, and a picture encoding and decoding system. The picture encoding method includes: determining an adjustment factor according to pixel sampling values of a video picture; converting the video picture according to the adjustment factor, and encoding the converted video picture; and writing the adjustment factor into a bitstream obtained by encoding the converted video picture.