Patents by Inventor Peng Khun LEONG

Peng Khun LEONG has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240366602
    Abstract: This disclosure provides methods for treating a condition or disease associated with weight gain that include coadministration of an apelin receptor agonist and a GLP-1 receptor agonist. Methods for increasing total weight loss in the subject relative to weight loss that would be caused by administration of a pre-determined amount of a GLP-1 receptor agonist alone are also provided. In some embodiments, the method is for preserving, or maintaining muscle mass, muscle function, and/or muscle strength in a subject undergoing weight loss therapy.
    Type: Application
    Filed: June 26, 2024
    Publication date: November 7, 2024
    Inventors: Kristen Patricia FORTNEY, Eric Kim MORGEN, Paul David RUBIN, Yong PAN, Yan WANG, Peng Khun LEONG, Justin REBO
  • Publication number: 20240252493
    Abstract: Apelin receptor modulators can improve physical performance, slow progression of age-related frailty, and can reduce age-related muscle weakness in human patients. This disclosure provides methods for treating muscle conditions using a particular class of apelin receptor modulators (e.g., agonists). The muscle condition can be an age-related muscle condition. Also provided is a method for maintaining and/or increasing muscle mass and/or muscle strength in an elderly subject by administration of the apelin receptor modulator. In some embodiments, the apelin receptor modulator (e.g., agonist) is BGE-105, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: April 6, 2022
    Publication date: August 1, 2024
    Inventors: Kristen Patricia Fortney, Eric Kim Morgen, Justin Rebo, Robert Hughes, Fred Aswad, Peng Khun Leong, Sashanaz H. Igdari, Paul David Rubin
  • Publication number: 20240122926
    Abstract: Apelin receptor modulators can improve physical performance, slow progression of age-related frailty, and can reduce age-related muscle weakness in human patients. This disclosure provides methods for treating muscle conditions using a particular class of apelin receptor modulators (e.g., agonists). The muscle condition can be an age-related muscle condition. Also provided is a method for maintaining and/or increasing muscle mass, muscle function, and/or muscle strength in an elderly subject by administration of the apelin receptor modulator. In some embodiments, the apelin receptor modulator (e.g., agonist) is BGE-105, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: September 27, 2023
    Publication date: April 18, 2024
    Inventors: Kristen Patricia FORTNEY, Eric Kim MORGEN, Justin REBO, Robert HUGHES, Fred ASWAD, Peng Khun LEONG, Sashanaz H. IGDARI, Paul David RUBIN, Rusty Lee MONTGOMERY
  • Publication number: 20240041878
    Abstract: This disclosure provides methods for using a particular class of apelin receptor modulators to reduce blood-brain barrier (BBB) permeability in a subject in need thereof, and in particular methods of treatment for a variety of disorders, conditions, and diseases associated with and related to increased BBB permeability. This disclosure also provides methods for using a particular class of apelin receptor modulators to treat a neurodegenerative disease, delirium, and/or dementia in a subject in need thereof. This disclosure also provides methods for using a particular class of apelin receptor modulators to reduce neuroinflammation in a subject in need thereof. In some embodiments, the apelin receptor modulator (e.g., agonist) is BGE-105, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: May 31, 2023
    Publication date: February 8, 2024
    Inventors: Justin REBO, Yan WANG, Adam LUNDQUIST, Matthew BANICKI, Robert HUGHES, Peng Khun LEONG