Abstract: The present disclosure concerns heme and methods of synthesis thereof. The present disclosure also concerns to compositions and products thereof. The heme composition comprises heme at about 0.05% w/w to about 1% w/w relative to the heme composition and an antioxidant at about 0.25% w/w to about 5% w/w relative to the heme composition, wherein the heme is derived from protoporphyrin IX extracted from a plant, algal, bacterial and/or animal source.

Abstract: The present disclosure provides a method of treating a condition associated with aging, including a disease or condition selected from anemia, including unexplained anemia of the elderly, spontaneous anemia of aging, and anemia of inflammation in the elderly, sarcopenia, frailty, tissue injury, muscle injury, and ischemic damage, the method comprising administering to an elderly subject a therapeutically effective amount of a hypoxia-inducible factor prolyl hydroxylase inhibitor.

Abstract: A communications server apparatus comprises a processor and a memory. The communications server apparatus is configured, under control of the processor, to execute instructions stored in the memory to receive, over a communications channel, link information relating to a caller input, the caller input being activation of a link in a page by a caller, the link being associated with an offer, and activation of the link being a request for a voice communication session between the caller and a call recipient about the offer. The communications server apparatus identifies the call recipient using the link information and initiates the voice communication session between a caller device associated with the caller and a recipient device associated with the call recipient. Supplementary information relating to the activation of the link is transmitted to the recipient device.