Abstract: The present invention relates to a method of synthesizing a compound of formula (I) also referred to as 4-(((2S,4S)-(4-ethoxy-1-(((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl))benzoic acid, or a pharmaceutically acceptable salt thereof, and/or intermediates thereof, their use as pharmaceuticals and pharmaceutical compositions and the use of intermediates for preparing a compound of formula (I), or a pharmaceutically acceptable salt thereof.

Abstract: A computer-implemented method, system and computer program product for improving understandability of text by a user. A final word vector for each word in a sentence of a document is computed, such as by averaging a first word vector and a second word vector for that word. Furthermore, elements of a user portrait are vectorized. A distance is then computed between a vector for each word in the sentence and a vectorized element in the user’s portrait which is summed to form an evaluation result for the element. An evaluation result is also formed for every other element in the user’s portrait by performing such a computation step. A “final evaluation result” is then generated corresponding to the evaluation results for every element in the user’s portrait. The document is then transformed in response to the final evaluation result indicating a lack of understanding of the sentence by the user.

Abstract: Compositions, systems and methods for delivering CRISPR/Cas9-based genome editing system and a donor protein to a cell.

Abstract: A carbon-coated nickel oxide nanocomposite material, its preparation, and application thereof are provided. The nanocomposite material contains carbon-coated nickel oxide nanoparticles having a core-shell structure including an outer shell that is a graphitized carbon film optionally doped with nitrogen and an inner core comprising nickel oxide nanoparticle(s). The nanocomposite material has a carbon content of from greater than 0 wt % to not greater than about 5 wt %, based on the weight of the nanocomposite material.

Abstract: A multi-lens camera includes a main housing assembly, lenses, a lens adjuster and a transparent cover. The transparent cover is mounted on the main housing assembly; the lens adjuster is mounted in the space formed by the main housing assembly and the transparent cover; the transparent cover includes a flat portion and a curved portion surrounding the flat portion; the lenses are located in the space covered by the curved portion; the lens adjuster includes a fixing disc and at least two lens brackets; each of the lens brackets includes a first bracket and a second bracket arranged on the first bracket; the first support is movably arranged on the fixing disc, and is capable of moving along the circumferential direction of the fixing disc; a lens is rotationally engaged with the second bracket, such that the lens rotates around axis thereof.

Abstract: Compositions, systems and methods for delivering CRISPR/Cas9-based genome editing system to a cell.

Abstract: A method for deliver relevant responses to ambiguous queries includes receiving, from a user device associated with a user, a query requesting either information from a digital assistant service or performance of an action by the digital assistant service. When a user intent of the query is unresolved, the method also includes retrieving, from a search engine, currently trending search results for the query and resolving the user intent of the query based on the search results. The method also includes generating a response to the query based the resolved user intent. The response includes information obtained from a particular intent vertical associated with the resolved user intent or fulfillment of the action by the digital assistant service.

Abstract: A nanocomposite has a core-shell structure with an outer shell and an inner core. The, outer shell is a graphitized carbon film, and the inner core contains nickel oxide and alumina, with a nickel oxide content of 59%-80%, an alumina content of 19%-40%, and a carbon content of not more than 1%, based on the total weight of the nanocomposite. The process for catalytic combustion of volatile organic compounds may utilize the nanocomposite as a catalyst.

Abstract: A layered modeling method for laser metal deposition (LMD) 3D printing. The layered modeling method includes: obtaining estimated printing parameters of each layer in an entire digital model based on a process database; obtaining estimated feature points of each layer through the estimated parameters; comparing estimated feature points of each layer with feature points of a corresponding actual shape to obtain a difference in each layer; and accumulating to obtain a difference in the entire digital model to obtain corresponding printing parameters. The layered modeling method has the advantages of effectively reducing the calculation amount during data comparison and greatly saving time.

Abstract: Disclosed are an online analysis system and method for a line loss of a transmission line. The system includes: a terminal extension and a terminal host, where time information synchronization between the terminal extension and the terminal host and between terminal extensions is performed by a clock synchronization module, and communication between the terminal extension and the terminal host and between the terminal extensions is performed by a communications module; and a line loss management platform, configured to receive measurement data of the terminal extension and the terminal host, match time information in the measurement data, and if time information in the measurement data of the terminal extension and the terminal host is matched, and time information in measurement data of the terminal extensions is matched, determine corresponding line loss information based on corresponding measurement information.

Abstract: A method for manufacturing a board-to-board connecting structure, including providing a first circuit board, including a first dielectric layer, a second dielectric layer stacked on the first dielectric layer, and a first wiring layer sandwiched between the first dielectric layer and the second dielectric layer. A second circuit board is provided, including a third dielectric layer, a fourth dielectric layers stacked on the third dielectric layer, and a second wiring layer sandwiched between the third dielectric layer and the fourth dielectric layer. The first step and the fourth dielectric layer are bonded through a first adhesive layer. The third step and the dielectric layer are bonded through a second adhesive layer. The second step and the fourth step are bonded through the conductive layer.

Abstract: A method for manufacturing a board-to-board connecting structure, including providing a first circuit board, including a first dielectric layer, a second dielectric layer stacked on the first dielectric layer, and a first wiring layer sandwiched between the first dielectric layer and the second dielectric layer. A second circuit board is provided, including a third dielectric layer, a fourth dielectric layers stacked on the third dielectric layer, and a second wiring layer sandwiched between the third dielectric layer and the fourth dielectric layer. The first step and the fourth dielectric layer are bonded through a first adhesive layer. The third step and the dielectric layer are bonded through a second adhesive layer. The second step and the fourth step are bonded through the conductive layer.

Abstract: A fast active DCAP cell which has a short turn-on time, achieves a high capacitance density, and which minimizes leakage overhead during its normal operation mode is disclosed. The DCAP cell has a pair of PMOS transistors that have their drains connected to a gate of a PMOS transistor and their sources connected to the VDD rail. The drain and source of the PMOS transistor are connected to the VSS rail. Likewise, the DCAP cell has a pair of NMOS transistors that have their drains connected to a gate of an PMOS transistor and their sources connected to the VSS rail. The drain and source of the PMOS transistor are connected to the VDD rail. None of the gates of the transistors is connected to the VDD or VSS rail. This protects the gate oxide from being damaged by ESD surge currents.

Abstract: A fast active DCAP cell which has a short turn-on time, achieves a high capacitance density, and which minimizes leakage overhead during its normal operation mode is disclosed. The DCAP cell has a pair of PMOS transistors that have their drains connected to a gate of a PMOS transistor and their sources connected to the VDD rail. The drain and source of the PMOS transistor are connected to the VSS rail. Likewise, the DCAP cell has a pair of NMOS transistors that have their drains connected to a gate of an PMOS transistor and their sources connected to the VSS rail. The drain and source of the PMOS transistor are connected to the VDD rail. None of the gates of the transistors is connected to the VDD or VSS rail. This protects the gate oxide from being damaged by ESD surge currents.