Abstract: Provided are methods of sensitizing LKB1/STK11 deficient cancers to immune therapy. A method for treatment for LKB1/STK11 deficient cancers is provided comprising administration of inhibitor or inhibitors of one or more of NAMPT, CD38, SHP2, CXCR1/2, HDAC4 and PARP in combination with immunotherapy.

Abstract: A control parameter adjustment method of lens includes: capturing an external image through a lens of an electronic device, and presenting an image screen corresponding to the external image through a display; receiving a first user operation through a user interface circuit; in response to the first user operation, activating a first parameter adjustment mode corresponding to the lens and providing a first parameter adjustment interface adjusting a control parameter of the lens based on a first virtual scale; in the first parameter adjustment mode, receiving a second user operation through the user interface circuit; and in response to the second user operation, activating a second parameter adjustment mode corresponding to the lens and providing a second parameter adjustment interface adjusting the control parameter of the lens based on a second virtual scale, and the first virtual scale is different from the second virtual scale.

Abstract: The disclosure provides a time-lapse photographic device. The time-lapse photographic device includes a camera module, a drive module, an environment detection module, and a control unit. The drive module is connected to the camera module to drive the camera module to rotate. The environment detection module is configured to detect an external environment of the time-lapse photographic device to generate an environment detection signal. The control unit is electrically connected to the camera module, the drive module, and the environment detection module. The control unit generates, according to a shooting stop parameter, a plurality of intermittent drive signals to control the drive module, and controls the camera module to shoot at intervals of the drive signals. The control unit adjusts operation of at least one of the camera module and the drive module according to the environment detection signal.

Abstract: Interpretation: This is the first ever report to uncover a tangible lipidomic basis by which maternal emotional well-being may influence fetal neurodevelopment and the later risk for psychopathology. This novel insight points to the potential utility of nutritional approaches among pregnant women with high levels of depressive symptoms in the prevention of offspring risk for later socio-emotional behavioral problems predictive of future psychopathology. Such a novel approach is particularly pertinent in light of the preference to avoid pharmacological interventions such as anti-depressant medications during pregnancy.

Abstract: An adapter for a dispensing container in a planetary mixer and an adapter and dispensing container combination are provided. The container has a longitudinal axis and a transverse axis and includes a composition dispensing nozzle with a removable cap closing the dispensing nozzle, the removable cap having a first width dimension measured along the transverse axis, and a container part spaced apart from the dispensing nozzle along the longitudinal axis, the container part having a second width dimension measured along the transverse axis. The adapter includes a cavity for receiving the cap, the cavity having a transverse dimension that exceeds the first width dimension, and a passageway extending from the cavity for receiving the container therein, the passageway having a transverse dimension that is less than the first width dimension and less than the second width dimension.

Abstract: The present disclosure relates to a system and process for manufacturing patient personalized pharmaceutical compositions using superimposed revolution and rotation movements for dispersing, milling, melting, and/or de-aerating, where these superimposed revolution and rotation movements can be carried out in a single device in a pharmacy setting.

Abstract: The present disclosure relates to a system and process for manufacturing patient personalized pharmaceutical compositions using superimposed revolution and rotation movements for dispersing, milling, melting, and/or de-aerating, where these superimposed revolution and rotation movements can be carried out in a single device in a pharmacy setting.

Abstract: A fluid dispenser, comprising: an actuator with a rotatable dial; a valve assembly connected to the actuator, the valve assembly being configured so as to cause fluid to be drawn from a reservoir and released from the dispenser during at least part of the time when the dial is rotated from a start position to one of a plurality of dosage positions and back to the start position, the plurality of dosage positions being at different respective angular positions of the dial; the actuator being configured to provide perceptible feedback at each of the plurality of dosage positions.

Abstract: The present disclosure relates to a system and process for manufacturing patient personalized pharmaceutical compositions using superimposed revolution and rotation movements for dispersing, milling, melting, and/or de-aerating, where these superimposed revolution and rotation movements can be carried out in a single device in a pharmacy setting.

Abstract: The present disclosure relates to a system and process for manufacturing patient personalized pharmaceutical compositions using superimposed revolution and rotation movements for dispersing, milling, melting, and/or de-aerating, where these superimposed revolution and rotation movements can be carried out in a single device in a pharmacy setting.

Abstract: A fluid dispenser, comprising: an actuator with a rotatable dial; a valve assembly connected to the actuator, the valve assembly being configured so as to cause fluid to be drawn from a reservoir and released from the dispenser during at least part of the time when the dial is rotated from a start position to one of a plurality of dosage positions and back to the start position, the plurality of dosage positions being at different respective angular positions of the dial; the actuator being configured to provide perceptible feedback at each of the plurality of dosage positions.

Abstract: A compounding dispensing gun includes a pawl-spring assembly and a hand-housing assembly. The hand-housing assembly is coupled to the pawl-spring assembly. The hand-housing assembly has a handle. A plunger assembly extends through the hand-housing assembly and includes a push rod and a push rod head removably coupled to the push rod. The push rod has a plurality of first notches and a plurality of second notches formed thereon. The push rod selectively cooperates with the pawl-spring assembly to advance the push rod and the push rod head during a dispensing operation.

Abstract: A method is proposed for automatically generating a crane lifting path describing the motion of a crane. The method includes: laser scanning a plant to generate one or more point clouds; using the point clouds to identify objects to be lifted by the crane; rasterizing the laser scanned point clouds to generate digital data describing the plant and in a format for input to a Graphics Processing Unit (GPU); and iteratively optimizing a crane lifting path, including using the GPU and the digital data to detect collisions between one or more cranes and the plant if the crane follows the crane lifting path.

Abstract: A compounding dispensing gun includes a pawl-spring assembly and a hand-housing assembly. The hand-housing assembly is coupled to the pawl-spring assembly. The hand-housing assembly has a handle. A plunger assembly extends through the hand-housing assembly and includes a push rod and a push rod head removably coupled to the push rod. The push rod has a plurality of first notches and a plurality of second notches formed thereon. The push rod selectively cooperates with the pawl-spring assembly to advance the push rod and the push rod head during a dispensing operation.

Abstract: A multi-dose, metered dispenser and applicator for topical medications includes inner and outer cylinders and a plurality of expanding bases. These bases form part of a telescopic piston drive system that advances the main piston through the inner cylinder, in accordance with a selected dosage, to dispense a metered amount of the topical medication. The dosage may be selected by a switch located on an outside of the outer cylinder, and dispensed by rotating the inner cylinder relative to the outer cylinder. A tactile and audible feedback mechanism informs the user that the desired dosage of medication has been dispensed.

Abstract: An electronic device which comprises a lead frame comprising at least one clip, a capacitor comprising at least one terminal, the at least one terminal being received in the at least one clip, and a semiconductor chip attached to the lead frame.

Abstract: An electronic device which comprises a lead frame comprising at least one clip, a capacitor comprising at least one terminal, the at least one terminal being received in the at least one clip, and a semiconductor chip attached to the lead frame.

Abstract: An apparatus and associated method for singulating a first work piece from a plurality of stacked work pieces, the plurality of stacked work pieces comprising a second work piece adjacent the first work piece. A stripping member is engageable against the second work piece. A lifting member is engageable with the first work piece and displaceable with respect to the stripping member between first and second positions. In the lifting member first position the first and second work pieces are stacked; in the lifting member second position the first and second work pieces are unstacked. After unstacking, a supporting member is moveable to engage the unstacked first work piece, selectively supporting the first work piece.

Abstract: A toothbrush body includes an integral head, a body and a tail portion, wherein the head includes indents for receiving bristles and the tail portion, which is inclined relative to the body portion, includes an indent for receiving the base of an interdental brush.

Abstract: An apparatus and associated method for singulating a first work piece from a plurality of stacked work pieces, the plurality of stacked work pieces comprising a second work piece adjacent the first work piece. A stripping member is engageable against the second work piece. A lifting member is engageable with the first work piece and displaceable with respect to the stripping member between first and second positions. In the lifting member first position the first and second work pieces are stacked; in the lifting member second position the first and second work pieces are unstacked. After unstacking, a supporting member is moveable to engage the unstacked first work piece, selectively supporting the first work piece.