Abstract: Antibody drug conjugates (ADC's) that bind to CD37 protein and variants thereof are described herein. CD37 exhibits a distinct and limited expression pattern in normal adult tissue(s), and is aberrantly expressed in the cancers listed in Table I. Consequently, the ADC's of the invention in some embodiments provide a therapeutic composition for the treatment of cancer.

Abstract: An inverse recommender system for detecting out-of-pattern payment transactions includes a memory device and a processor programmed to receive transaction data. The transaction data corresponds to historical payment transactions between account holders and merchants. The processor is programmed to generate a merchant correspondence matrix including the merchants and counters indicating the number of historical payment transactions between merchant pairs of the merchants and the account holders. The processor is programmed to store the merchant correspondence matrix in a memory device linking the merchant pairs to each account holder. The processor receives additional transaction data associated with a new payment transaction between an account holder and a merchant, and to generate an inverse recommender score for the new payment transaction based on the account holder's historical payment transaction data.

Abstract: A method, apparatus, and storage medium for training a neural network model used for image processing are described. The method includes: obtaining a plurality of video frames; inputting the plurality of video frames through a neural network model so that the neural network model outputs intermediate images; obtaining optical flow information between an early video frame and a later video frame; modifying an intermediate image corresponding to the early video frame according to the optical flow information to obtain an expected-intermediate image; determining a time loss between an intermediate image corresponding to the later video frame and the expected-intermediate image; determining a feature loss between the intermediate images and a target feature image; and training the neural network model according to the time loss and the feature loss, and returning to obtaining a plurality of video frames continue training until the neural network model satisfies a training finishing condition.

Abstract: A semiconductor structure and a method for forming the semiconductor structure are provided. The method includes: providing a substrate; forming a dummy gate structure including a dummy gate dielectric layer, an initial dummy gate electrode layer, and a first sidewall spacer; forming an isolation layer having a surface lower than or coplanar with the dummy gate structure; forming a dummy gate electrode layer having a surface lower than the isolation layer, and forming a first opening to expose a portion of the first sidewall spacer; forming a modified sidewall spacer from the exposed first sidewall spacer; forming a second opening by removing the dummy gate electrode layer; forming a third opening by removing the dummy gate dielectric layer and the modified sidewall spacer, where top of the third opening has a size larger than bottom of the third opening; and forming a gate structure in the third opening.

Abstract: A method for manufacturing a three-dimensional (3D) memory structure and a 3D memory structure are disclosed. A recess is formed on a substrate, a 3D memory component is formed with a bottom in the recess, and then, a peripheral circuit is formed on the substrate outside the recess.

Abstract: The present disclosure provides a smart device function guiding method and system, wherein the method comprises: obtaining a user's speech data and obtaining an operation instruction corresponding to the speech data; judging whether the operation instruction complies with a preset guidance condition, and sending a guidance speech to the smart device if the operation instruction complies with the preset guidance condition. The solution of the present disclosure can be employed to improve the efficiency of performing function guidance through speech interaction as compared with the manner of performing the function guidance through the APP or providing simple speech function guidance in the prior art.

Abstract: A capacity analysis computing device for determining a restaurant capacity level is provided. The capacity analysis computing device is configured to store historical transaction data for a restaurant for a period of time, and analyze the historical transaction data to identify a maximum restaurant capacity for the restaurant over the period of time. The capacity analysis computing device is also configured to receive, from a user computing, a selected time interval for which a current capacity level is to be determined. The capacity analysis computing device is further configured to identify a similar historical time interval to the selected time interval, and determine a historical capacity level for the restaurant during the similar historical time interval. The capacity analysis computing device is further configured to assign the historical capacity level as the current capacity level for the restaurant, and display the current capacity level on the user computing device.

Abstract: The technology described herein is generally directed towards an integrated high-radix strictly non-blocking optical switching fabric, such as for use for intra-rack communication within racks in a data center. The fabric may be configured with any number of ports. A general topology of optical components, along with a routing controller (e.g., algorithm/mechanism), results in an optical switching fabric architecture that provides bidirectional routing, in a high-performance, high bandwidth, highly robust switching fabric that is also low in power consumption and low latency.

Abstract: An inverse recommender system for detecting out-of-pattern payment transactions includes a memory device and a processor programmed to receive transaction data. The transaction data corresponds to historical payment transactions between account holders and merchants. The processor is programmed to generate a merchant correspondence matrix including the merchants and counters indicating the number of historical payment transactions between merchant pairs of the merchants and the account holders. The processor is programmed to store the merchant correspondence matrix in a memory device linking the merchant pairs to each account holder. The processor receives additional transaction data associated with a new payment transaction between an account holder and a merchant, and to generate an inverse recommender score for the new payment transaction based on the account holder's historical payment transaction data.

Abstract: A vehicular radar device includes a radar module and a dustproofing element. The radar module has a casing and a radar sensor disposed in the casing. The casing has a first outer wall surface and a second outer wall surface opposing the first outer wall surface. The first outer wall surface faces an inner wall surface of a bumper. An emission surface of the radar sensor faces the first outer wall surface of the casing. The dustproofing element has two opposing dustproofing surfaces. The two dustproofing surfaces attach to the first outer wall surface of the casing of the radar module and the inner wall surface of the bumper, respectively. Therefore, the vehicular radar device effectively precludes influences of ambient dust on performance of the radar sensor, so as to enhance sensing sensitivity of the radar sensor and extend its service life.

Abstract: A compensating display screen, an optical system, and an electronic device are provided. The compensating display screen includes: a transparent display screen, comprising a plurality of periodically arranged pixel units for display; and a compensating element, configured to compensate a diffraction effect of the transparent display screen, so that when a preset light beam is incident on the compensating display screen, the same preset light beam is emitted from the compensating display screen. An optical system, comprises the above compensating display screen, and an optical module configured to receive a light beam from the transparent display screen or emit a light beam outward through the transparent display screen. An electronic device, comprises the above optical system, and a filter unit disposed between the transparent display screen and the optical module, and configured to reduce passage of visible light from the transparent display screen.

Abstract: An optical system, an electronic device, and a method for designing a diffractive optical element of an optical system are provided. The optical system comprises: a transparent display screen, comprising a plurality of periodically arranged pixel units for display; and a light emitting module, comprising a light source and a diffractive optical element, and configured to emit a patterned light beam outward through the transparent display screen. The diffractive optical element is configured to receive an incident light beam from the light source and project a first diffracted light beam, wherein the first diffracted light beam is incident on the transparent display screen and then diffracted again, such that the patterned light beam is projected outward. An electronic device, comprises the above optical system, and a filter unit disposed between the transparent display screen and the optical module, and configured to reduce passage of visible light from the transparent display screen.

Abstract: The invention relates to poly oxometalates represented by the formula (An)m+{M?s[M?M15X10OyRzHq]}m? or solvates thereof, corresponding supported polyoxometalates, and processes for their preparation, as well as corresponding metal-clusters, optionally in the form of a dispersion in a liquid carrier medium or immobilized on a solid support, and processes for their preparation, as well as their use in reductive conversion of organic substrate.

Abstract: A 3D printing method for binary stereolithography 3D printer includes following steps of: controlling a binary stereolithography 3D printer (20) to retrieve a plurality of gray-scale slice images (802,822,842); mapping a pixel value of each pixel of each gray-scale slice images (802,822,842) from a pixel value full range to an accumulation value range for obtaining a printing parameter of each pixel; selecting one of the gray-scale slice images (802,822,842) orderly; controlling a binary lighting module (204) of the binary stereolithography 3D printer (20) to irradiate for generating a layer of physical slice model (320,322,340,342) according to the printing parameter of each pixel of the selected gray-scale slice image (802,822,842); and repeatedly executing aforementioned steps to generate a physical 3D model (8?) constituted by a stack of multiple of the physical slice models (320,322,340,342).

Abstract: A three-dimensional printing apparatus and a three-dimensional printing method are provided. The three-dimensional printing apparatus includes a tank, an injection module, a platform movably disposed above the bottom of the tank, a curing module, and a control module. The tank has a forming area and a separating area in a stepped manner on a bottom thereof, and the forming area is higher than the separating area. The injection module includes a storage tank and an injection pipe connected thereto, and a forming material is filled therein to be applied to the forming area. The curing module is disposed beside the tank or the platform to cure the forming material between the platform and the forming area to be a curing layer. The control module is electrically connected to the injection module, the curing module, and at least one of the tank and the platform to perform a relative movement.

Abstract: The technology described herein is generally directed towards an integrated high-radix strictly non-blocking optical switching fabric, such as for use for intra-rack communication within racks in a data center. The fabric may be configured with any number of ports. A general topology of optical components, along with a routing controller (e.g., algorithm/mechanism), results in an optical switching fabric architecture that provides bidirectional routing, in a high-performance, high bandwidth, highly robust switching fabric that is also low in power consumption and low latency.

Abstract: Disclosed herein are novel cannabionid receptor-2 (CB2) agonists and inverse agonists represented by Formula (I), and method of modulating the activity of CB2 by contacting the CB-2 receptor with a compound of Formula (I). Also, disclosed are methods for treating multiple myeloma or osteoporosis in a mammal in need thereof by modulating the activity of a cannabinoid receptor-2 (CB2).

Abstract: Provided herein are compositions, methods and uses involving antibodies that specifically bind to Nectin-4. Also provided herein are methods for assessing Nectin-4 expression in a sample or a patient and methods for assessing responsiveness of a cancer patient to an anti-cancer therapeutic agent.

Abstract: An information processing method, apparatus and video surveillance system have expandable functionality. The information processing method has an image acquisition step of acquiring an image; a first party feature quantity extracting step of extracting at least one first party feature quantity for describing a first party feature of the image from the acquired image; a third party feature quantity extracting step of invoking a third party algorithm to extract from the image at least one third party feature quantity for describing a third party feature other than the first party feature of the image; and a feature quantity correlation step of using the link information for describing the correlation between each of the first party feature quantities and each of the third party feature quantities of the same image to correlate each of the first party feature quantities of the image and each of the third party feature quantities.