Abstract: The present application provides immune cells (such as T cells) comprising a chimeric antibody-T cell receptor (TCR) construct (caTCR) and a chimeric signaling receptor (CSR) construct. The caTCR comprises an antigen-binding module that specifically binds to a target antigen and a T cell receptor module (TCRM) capable of recruiting at least one TCR-associated signaling molecule, and the CSR comprises a ligand-binding domain that specifically binds to a target ligand and a co-stimulatory signaling domain capable of providing a stimulatory signal to the immune cell. Also provided are methods of making and using these cells.

Abstract: Described herein are antibodies (e.g., single chain variable fragment (scFv) antibodies) and constructs comprising antibody moieties that bind to the extracellular domain of CD22 or a portion thereof (e.g., SEQ ID NO: 205 or a portion thereof). Also provided herein are methods of using the same or compositions thereof for the therapeutic treatment of diseases characterized by CD22 expression, in particular, B-cell lymphomas and leukemias.

Abstract: Described herein are immune cells comprising: a T-cell receptor (TCR) and a chimeric stimulating receptor (CSR) that comprises (i) a ligand-binding module that is capable of binding or interacting with a target ligand; (ii) a transmembrane domain; and (iii) a CD30 costimulatory domain, in which the CSR in the immune cells lacks a functional primary signaling domain. Also provided herein are methods of using the same or components thereof (e.g., the CSR) for therapeutic treatment of cancers (e.g., solid tumor cancers).

Abstract: The present application provides constructs comprising an antibody moiety specifically recognizing Glypican 3 (GPC3), such as a cell surface-bound GPC3. Also provided are methods of making and using these constructs.

Abstract: Described herein are immune cells comprising: a chimeric antigen receptor (CAR) that comprises (i) an extracellular target-binding domain comprising an antibody moiety; (ii) a transmembrane domain; and (iii) a primary signaling domain, and a chimeric stimulating receptor (CSR) that comprises (i) a ligand-binding module that is capable of binding or interacting with a target ligand; (ii) a transmembrane domain; and (iii) a CD30 costimulatory domain, in which the CSR in the immune cells lacks a functional primary signaling domain. Also provided herein are methods of using the same or compositions thereof for therapeutic treatment of cancers (e.g., hematological cancers or solid tumor cancers).

Abstract: The present application provides constructs comprising an antibody moiety specifically recognizing Glypican 3 (GPC3), such as a cell surface-bound GPC3. Also provided are methods of making and using these constructs.

Abstract: To manage a storage system, data objects are divided to groups according to keyword ranges of the data objects in the storage system. Array sets associated with the groups are respectively generated. An array in the array set includes elements. The elements are set according to a keyword of at least one data object in the group and at least one hash function. At least a part of the arrays in the array sets respectively associated with the groups is loaded into a memory of the storage system. The storage system is managed based on at least the part of the arrays in the memory. Further, a corresponding device and a corresponding computer program product are provided. With the above example implementation, only a part of the arrays is loaded into the memory of the storage system, so that the overhead of memory resources can be reduced.

Abstract: Described herein are chimeric antigen receptors (CARs) comprising an extracellular target-binding domain comprising an antibody moiety (e.g., a single chain variable fragment (scFv) antibody), a transmembrane domain, a CD30 costimulatory domain, and a primary signaling domain. Also provided herein are methods of using the same or compositions thereof for the therapeutic treatment of cancers (e.g., hematological cancers or solid tumor cancers).

Abstract: The present application provides constructs comprising an antibody moiety that specifically binds to PSMA (e.g., PSMA expressed on the surface of a cell). Also provided are methods of making and using these constructs.

Abstract: Data processing techniques comprise, in response to determining that a storage unit storing first data blocks is damaged, determining storage units associated with the storage unit, and obtaining second data blocks from the storage units, where the second data blocks and the first data blocks are generated by applying to data an error correction code in a first format. The method further comprises recovering the first data blocks based on the second data blocks. In addition, the method comprises generating error correction blocks by applying an error correction code in a second format to the recovered first data blocks, where the second format is different from the first format. The above techniques can reduce input/output operations and shortens the recovery time of data blocks, and further can reduce the risk of data loss even in an extremely bad situation.

Abstract: A fingerprint identification system for a mobile phone and an identification method. The system includes a fingerprint collection module, a spectral chip, a data storage module and an identification module. The fingerprint collection module is arranged under a mobile phone screen. The mobile phone screen provides a light source to illuminate a fingerprint. The spectral chip is configured to modulate an incident spectrum, and convert an optical signal into an electrical signal to be amplified and converted into a digital signal or code for output. A finger reflection spectral data and a fingerprint image data are collected by inversion of an optical signal intensity information and a pixel location information. The data storage module is configured to store reflection spectral data and fingerprint image data of a real finger input in advance. The identification module is configured to compare the collected data with the pre-stored data.

Abstract: Embodiments of the present disclosure provide a method, an electronic device and a computer-readable medium for managing metadata. The method disclosed herein comprises: obtaining a check marker from a remote device; determining whether the check marker indicates that user data and metadata have been backed up in the remote device, the user data and the metadata being generated by an operation executed by a user on an object; and in response to the check marker indicating that the user data and the metadata have been backed up in the remote device, marking the metadata as removable metadata. In this way, the embodiments of the present disclosure can improve garbage collection efficiency of a storage system and execution efficiency of a metadata integration task.

Abstract: To manage a storage system, data objects are divided to groups according to keyword ranges of the data objects in the storage system. Array sets associated with the groups are respectively generated. An array in the array set includes elements. The elements are set according to a keyword of at least one data object in the group and at least one hash function. At least a part of the arrays in the array sets respectively associated with the groups is loaded into a memory of the storage system. The storage system is managed based on at least the part of the arrays in the memory. Further, a corresponding device and a corresponding computer program product are provided. With the above example implementation, only a part of the arrays is loaded into the memory of the storage system, so that the overhead of memory resources can be reduced.

Abstract: The present application provides constructs comprising an antibody moiety specifically recognizing Glypican 3 (GPC3), such as a cell surface-bound GPC3. Also provided are methods of making and using these constructs.

Abstract: The present application provides immune cells (such as T cells) comprising a chimeric antibody-T cell receptor (TCR) construct (caTCR) and a chimeric signaling receptor (CSR) construct. The caTCR comprises an antigen-binding module that specifically binds to a target antigen and a T cell receptor module (TCRM) capable of recruiting at least one TCR-associated signaling molecule, and the CSR comprises a ligand-binding domain that specifically binds to a target ligand and a co-stimulatory signaling domain capable of providing a stimulatory signal to the immune cell. Also provided are methods of making and using these cells.

Abstract: The present disclosure relates to a method, apparatus and computer program product for managing a storage system. According to implementations of the present disclosure, there is provided a method for managing a storage system. In the method, an object vector is created based on multiple objects stored in the storage system, here an object element in the object vector is associated with at least one object among the multiple objects. Multiple chunks included in the storage system are divided into multiple groups. For a group among the multiple groups, a chunk vector is created based on each chunk in the group, here a chunk element in the chunk vector is associated with a chunk in the group. A mapping matrix is created for managing the storage system based on the object vector and the chunk vector. Moreover, there is provided an apparatus and computer program product for managing a storage system.

Abstract: Described herein are antibodies (e.g., single chain variable fragment (scFv) antibodies) and constructs comprising antibody moieties that bind to the extracellular domain of CD22 or a portion thereof (e.g., SEQ ID NO: 205 or a portion thereof). Also provided herein are methods of using the same or compositions thereof for the therapeutic treatment of diseases characterized by CD22 expression, in particular, B-cell lymphomas and leukemias.

Abstract: The present application provides immune cells (such as T cells) comprising a chimeric antibody-T cell receptor (TCR) construct (caTCR) and a chimeric signaling receptor (CSR) construct. The caTCR comprises an antigen-binding module that specifically binds to a target antigen and a T cell receptor module (TCRM) capable of recruiting at least one TCR-associated signaling molecule, and the CSR comprises a ligand-binding domain that specifically binds to a target ligand and a co-stimulatory signaling domain capable of providing a stimulatory signal to the immune cell. Also provided are methods of making and using these cells.

Abstract: Data processing techniques comprise, in response to determining that a storage unit storing first data blocks is damaged, determining storage units associated with the storage unit, and obtaining second data blocks from the storage units, where the second data blocks and the first data blocks are generated by applying to data an error correction code in a first format. The method further comprises recovering the first data blocks based on the second data blocks. In addition, the method comprises generating error correction blocks by applying an error correction code in a second format to the recovered first data blocks, where the second format is different from the first format. The above techniques can reduce input/output operations and shortens the recovery time of data blocks, and further can reduce the risk of data loss even in an extremely bad situation.

Abstract: Embodiments of the present disclosure provide a method, an electronic device and a computer-readable medium for managing metadata. The method disclosed herein comprises: obtaining a check marker from a remote device; determining whether the check marker indicates that user data and metadata have been backed up in the remote device, the user data and the metadata being generated by an operation executed by a user on an object; and in response to the check marker indicating that the user data and the metadata have been backed up in the remote device, marking the metadata as removable metadata. In this way, the embodiments of the present disclosure can improve garbage collection efficiency of a storage system and execution efficiency of a metadata integration task.