Abstract: The present disclosure relates to the fields of nuclear medicine and molecular imaging, and specifically relates to a dual-targeting compound and a preparation method and application thereof. The dual-targeting compound has the following structure shown in Formula (I). The present disclosure also provides a dual-targeting compound capable of being labeled with a radionuclide, and the compound has the following structure shown in Formula (I-1) or Formula (I-2). The dual-targeting compound of the present disclosure has high affinity for an FAP target and an integrin ?v?3 target, can realize synergistic targeting of the FAP target and the integrin ?v?3 target in tumors, and has high uptake in tumors and long retention time in tumors.

Abstract: The present disclosure is related to systems and methods for indoor positioning. The method includes obtaining a first location of a subject at a first time point. The method also includes determining one or more motion parameters associated with the subject at least based on one or more sensors carried by the subject. The method further includes determining, based on the first location of the subject and the one or more motion parameters associated with the subject, a second location of the subject at a second time point after the first time point. The method still further includes adjusting, at least based on surroundings information associated with the subject at the second time point, the second location of the subject to determine a target location of the subject.

Abstract: A battery module includes: a plurality of cells; and a cell restraining structure having an internal frame and an external shell fit with the internal frame to form a plurality of chambers for receiving the plurality of cells respectively so as to package and manage the cells. The internal frame includes an elastic element forming at least one first surface of each chamber, the elastic element being elastically deformed as being pressed by a predetermined amount by a corresponding cell received in each chamber such that the elastically deformed elastic element exerts a first force to the corresponding cell. The elastically deformed elastic element is further pressed or tends to recover in responding to reversible expansion or contraction of the corresponding cell in operation such that a restraining force to the corresponding cell is determined by the first force.

Abstract: The present disclosure provides a compound targeting prostate specific membrane antigen (PSMA), wherein the compound has the following structure shown in Formula (I); R1 is a compound structure targeting prostate specific membrane antigen; L1 is -(X)n-(CH2)m-(Y)q-, X and Y are independently selected from lysine, glutamic acid or a derivative structure containing lysine and glutamic acid, n is an integer from 0 to 12, m is an integer from 0 to 60, q is an integer from 0 to 12, and each CH2 may be individually substituted with —O—, —NH(CO)—, or —(CO)—NH—; L2 is -(CH2)p-, p is an integer from 0 to 30, and each CH2 may be individually substituted with —O—, —NH(CO)—, or —(CO)—NH—; and R2 is a nuclide chelating group. The present disclosure also provides a radiolabeled complex based on the structure of the compound.

Abstract: The present disclosure provides a cobalt-free and nickel-free positive electrode material and a preparation method therefor, and a battery. The preparation method includes: preparing a cobalt-free and nickel-free matrix material, and mixing the cobalt-free and nickel-free matrix material, a lithium source, and a divalent manganese compound for reaction to obtain the cobalt-free and nickel-free positive electrode material. By adding the divalent manganese compound, the generation of lamellar LiMnO2 and spinel LiMn2O4 is inhibited, the generation of lamellar Li2MnO3 is promoted, and the cycle performance of the material is improved.

Abstract: A road structure reconstructed from large-scale independent underground garage and a construction method, which solves the problem of a newly constructed urban expressway passing through large underground space. The technical point is a construction method for the road structure reconstructed from large-scale independent underground garage, including the following steps: S100: segmentation for the garage, S200: preparation before construction: the materials and equipment required for construction are transported to the site, and the construction site is cleaned, S300: reconstruction for the front section, S400: reconstruction for the middle section, S500: reconstruction for the rear section. The inventiveness of the present disclosure is the application of segmentation construction, the front section is completely obsoleted, a transition section is provided at the middle, and the design of the rear section adopts a double-deck road, thus the original underground garage structure is fully utilized.

Abstract: The present disclosure provides a compound targeting prostate specific membrane antigen (PSMA), wherein the compound has the following structure shown in Formula (I); R1 is a compound structure targeting prostate specific membrane antigen; L1 is —(X)n—(CH2)m—(Y)q—, X and Y are independently selected from lysine, glutamic acid or a derivative structure containing lysine and glutamic acid, n is an integer from 0 to 12, m is an integer from 0 to 60, q is an integer from 0 to 12, and each CH2 may be individually substituted with —O—, —NH(CO)—, or —(CO)—NH—; L2 is —(CH2)p—, p is an integer from 0 to 30, and each CH2 may be individually substituted with —O—, —NH(CO)—, or —(CO)—NH—; and R2 is a nuclide chelating group. The present disclosure also provides a radiolabeled complex based on the structure of the compound.

Abstract: The disclosure provides a composite anode electrode material and a preparation method thereof, an anode electrode material and a lithium ion battery. The composite anode electrode material includes a defect-type transition metal oxide and a lithium titanate, wherein the lithium titanate is compounded with the defect-type transition metal oxide in the manner of coating and/or doping, the defect-type transition metal oxide is a secondary particle, and a transition metal element in the defect-type transition metal oxide is selected from any one of tungsten, yttrium and tin. The probability of a side reaction between the defect-type transition metal oxide and an electrolyte is greatly reduced and a volume expansion effect of an anode electrode of a battery in the process of deintercalating lithium ions is greatly reduced, thereby the lithium ion battery including the composite anode electrode material has a higher capacity retention rate after cycling.

Abstract: The present disclosure provides a three-dimensional element layout visualization method and apparatus. The three-dimensional element layout visualization method includes: determining a bounding box of each three-dimensional element in a visualization interface; projecting the bounding box of each three-dimensional element in a target projection direction to obtain edge elements of the bounding box of each three-dimensional element in the visualization interface; and determining, according to positions of the edge elements in the visualization interface, at least one edge element set satisfying a first preset condition, and displaying a collinearity identification corresponding to the edge element set in the visualization interface.

Abstract: Systems and methods for updating a model of a building are provided. The method includes obtaining a three-dimensional (3D) model of a building including reference environmental data associated with a plurality of reference locations of the building and obtaining current environmental data corresponding to a current location of the building. The method further includes identifying, from the 3D model, a target reference location corresponding to the current location from the plurality of reference locations of the building and comparing the current environmental data with the target reference environmental data. The method further includes sending to the user device the target reference location when the current environmental data match the target reference environmental data, and updating the 3D model with the current environmental data when the current environmental data statistically un-match the target reference environmental data.

Abstract: The present disclosure provides a truncated Evans Blue modified fibroblast activation protein inhibitor compound. The compound is formed by connecting truncated Evans Blue, a fibroblast activation protein inhibitor and a nuclide chelating group by means of connecting groups L1, L2, L3, L4 and X. The compound has the following structure shown in Formula (I), where R1 is a fibroblast activation protein inhibitor; L1 is lysine, glutamic acid, or a derivative structure thereof; L2 is —(CH2)n—, n is an integer from 0 to 30, and each —CH2— may be individually substituted or unsubstituted with —O—, —NH—, —(CO)—, —NH(CO)—, or —(CO)—NH—; L3 is —(CH2)m—, m is an integer from 0 to 30, and each —CH2— may be individually substituted or unsubstituted with —O— or —(CO)—; L4 is —(CH2)p—, p is an integer from 0 to 30, and each —CH2— may be individually substituted or unsubstituted with —O—, —NH—, —(CO)—, —NH(CO)—, or —(CO)—NH—; X is selected from N, C, O, S, or and R2 is a nuclide chelating group.

Abstract: The invention relates to the field of building ceramic materials, and specifically discloses a soft light super-wear-resistant diamond glaze, a ceramic tile and a preparation method thereof. The main raw materials of the super-wear-resistant diamond glaze in parts by weight are as follows: 30-70 parts of a frit, 20-55 parts of an aggregate, 0.1-6 parts of an additive, 30-50 parts of water; the frit contains Al2O3?10%, Na2O+K2O?3%. Correspondingly, the present invention also discloses a super-wear-resistant diamond glazed ceramic tile and a preparation method thereof. The diamond glaze disclosed in present invention has the characteristics of excellent transparency, good wear resistance and stain resistance and almost has no air bubbles.

Abstract: The present disclosure relates to the field of survey and stability evaluation of a tailing fill dam, in particular to a method and system for survey and stability evaluation of an upstream tailing fill dam, wherein the method comprises the following steps: selecting a drill bit and a soil sampler for a target tailing fill dam; collecting tailing sand at different depths of the target tailing fill dam using the drill bit and the soil sampler; detecting an undisturbed soil sample of the tailing sand; setting a preset standard according to the undisturbed soil sample, and screening the tailing sand using the preset standard to obtain a tailing sand sample; detecting the particle composition of the tailing sand sample; detecting the mechanical property of the tailing sand sample; and evaluating the stability of the target tailing fill dam through the particle composition and the mechanical property.

Abstract: A nanobody or an antigen-binding fragment thereof against a specific region of a factor XII (FXII) is provided. The nanobody or the antigen-binding fragment thereof binds to FXII through a binding epitope for FXII to block the activation of FXII, and the binding epitope for FXII includes a conformational epitope. A neutralizing antibody for FXII screened by phage display is provided, and it has been found that the neutralizing antibody can treat thrombosis, myocardial ischemia-reperfusion injury (IRI), and vasculitis in mouse arterial thrombosis, rat extracorporeal membrane oxygenation (ECMO), mouse IRI, and vasculitis models.

Abstract: The disclosure discloses a synthesis method of hexafluorophosphate, belonging to the technical field of chemical synthesis. The synthesis method of hexafluorophosphate is characterized by comprising the following steps: reacting a phosphorus pentahalide inert solvent solution obtained by dissolving phosphorus pentahalide into an inert solvent with an alkali metal fluoride salt hydrogen fluoride solution obtained by dissolving an alkali metal halide salt into anhydrous hydrogen fluoride in a reactor in a ratio to obtain a mixture consisting of hexafluorophosphate, hydrogen fluoride, the inert solvent and hydrogen halide, performing gas-liquid separation to remove a hydrogen halide gas, then heating and evaporating to recover hydrogen fluoride, finally performing solid-liquid separation to recover the inert solvent, and then drying the solid to obtain hexafluorophosphate.

Abstract: The present disclosure relates to systems and methods for identifying one or more target roads. The systems may perform the methods to obtain a heat map associated with a plurality of driving track points along a plurality of roads in a target region, wherein the plurality of roads includes one or more target roads and one or more reference roads; obtain a road network map associated with the one or more reference roads in the target region; produce an intermediate heat map by: eliminating pixels in the heat map corresponding to the one or more reference roads in the road network map, eliminating background pixels corresponding to background of the heat map, and thinning the heat map; and determine start coordinate information and end coordinate information associated with the one or more target roads based on the intermediate heat map according to a linear transformation.

Abstract: The invention relates to the field of building ceramic materials, and specifically discloses a soft light super-wear-resistant diamond glaze, a ceramic tile and a preparation method thereof. The main raw materials of the super-wear-resistant diamond glaze in parts by weight are as follows: 30-70 parts of a frit, 20-55 parts of an aggregate, 0.1-6 parts of an additive, 30-50 parts of water; the frit contains Al2O3?10%, Na2O+K2O?3%. Correspondingly, the present invention also discloses a super-wear-resistant diamond glazed ceramic tile and a preparation method thereof. The diamond glaze disclosed in present invention has the characteristics of excellent transparency, good wear resistance and stain resistance and almost has no air bubbles.

Abstract: A method and device for calculating an optimal leveling stiffness of pile top displacement regulators in a composite foundation are disclosed. The method includes: determining basic parameters for calculating the optimal leveling stiffness of the pile top displacement regulators in the composite foundation; building an optimal mathematical model for calculating the optimal leveling stiffness of the pile top displacement regulators in the composite foundation, and solving the optimal mathematical model for calculating the optimal leveling stiffness of the pile top displacement regulators in the composite foundation to obtain the optimal leveling stiffness. The method and device maximize the bearing capacity of the composite foundation by taking an optimal value of the leveling stiffness of the pile top displacement regulators. The method and device realize accurate quantitative analysis for composite foundation design by adjusting the value of the leveling stiffness of the pile top displacement regulators.

Abstract: A myocardial multi-parametric ultrasound imaging method includes: emitting alternately a plurality of ascending and descending large-acoustic domain diverging waves to myocardial tissue to obtain raw channel data; performing beamforming to obtain a plurality of radio frequency data; performing myocardial edge detection and identification according to the radio frequency data to generate myocardial mask; and estimating a large-displacement estimation term, a small-displacement estimation term, and a regularization term to construct a myocardial displacement estimation cost function; and obtaining the myocardial displacement parameters according to the cost function; and performing strain estimation. A myocardial multi-parametric ultrasound imaging system is further provided.