Patents by Inventor Pengguang Wu

Pengguang Wu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • High-throughput screening assays for modulators of STAT4 activity
    Patent number: 6682898
    Abstract: This invention provides receptor peptides that have a high affinity for STAT4 and STAT6 polypeptides. Also provided are assays that are useful for identifying compounds that modulate the interaction between STAT4 and STAT6 polypeptides and their respective cellular promoters. The assays are amenable to high throughput screening.
    Type: Grant
    Filed: March 26, 2001
    Date of Patent: January 27, 2004
    Assignee: Tularik Inc.
    Inventors: Pengguang Wu, Judi McKinney
  • High-throughput screening assays for modulators of STAT4 and STAT6 activity
    Publication number: 20020039749
    Abstract: This invention provides receptor peptides that have a high affinity for STAT4 and STAT6 polypeptides. Also provided are assays that are useful for identifying compounds that modulate the interaction between STAT4 and STAT6 polypeptides and their respective cellular promoters. The assays are amenable to high throughput screening.
    Type: Application
    Filed: March 26, 2001
    Publication date: April 4, 2002
    Inventors: Pengguang Wu, Judi McKinney
  • High-throughput screening assays for modulators of STAT4 and STAT6 activity
    Patent number: 6207391
    Abstract: This invention provides receptor peptides that have a high affinity for STAT4 and STAT6 polypeptides. Also provided are assays that are useful for identifying compounds that modulate the interaction between STAT4 and STAT6 polypeptides and their respective cellular promoters. The assays are amenable to high throughput screening.
    Type: Grant
    Filed: March 31, 1998
    Date of Patent: March 27, 2001
    Assignee: Tularik Inc.
    Inventors: Pengguang Wu, Judi McKinney
  • High-throughput screening assay for inhibitors of nucleic acid polymerases
    Patent number: 5635349
    Abstract: The invention provides promoter specific and promoter non-specific screening assays for identifying an inhibitor of a pathogenic nucleic acid polymerase activity, e.g. an RNA polymerase derived from a pathogenic infectious organism such as a bacterium, protozoan or fungus. Generally, the methods involve forming a mixture of nucleotides, a polynucleotide template, a pathogenic polymerase candidate inhibitor of polymerase activity, where at least one of the nucleotides comprises a detectable label. The mixture is incubated under conditions whereby, but for the presence of the candidate inhibitor, the polymerase transcribes the polynucleotide template by catalyzing the polymerization of the nucleoside triphosphates into a polynucleotide having a nucleotide sequence complementary to that of the polynucleotide template. The nascent transcript is captured by a polynucleotide-selective agent immobilized on a solid substrate for subsequent washing and label detection.
    Type: Grant
    Filed: December 2, 1994
    Date of Patent: June 3, 1997
    Assignee: Tularik, Inc.
    Inventors: Kelly LaMarco, Berta Strulovici, Pengguang Wu