Abstract: The present disclosure provides, in part, methods of discovering immunotherapy targets in vivo, therapeutic compositions (e.g., shRNA, immunoresponsive cells expressing shRNA and/or a chimeric antigen receptors (CAR)), and methods of use thereof.

Abstract: The present disclosure provides a steering system of an engineering vehicle, and a backhoe loader. The steering system includes: a direction control device, including a steering wheel, a steering cylinder and steerable wheels, the steering cylinder being in transmission connection with the steering wheel and the steerable wheels; a displacement sensor configured to detect a piston displacement of the steering cylinder; a return motor in transmission connection with the steerable wheels to drive the steerable wheels to return to a normal position; and a controller in signal connection with the displacement sensor and the return motor, and configured to output a control signal according to the piston displacement detected by the displacement sensor to manipulate the return motor to drive the steerable wheels to return. The backhoe loader includes the steering system.

Abstract: The present disclosure provides, in part, methods of discovering immunotherapy targets in vivo, therapeutic compositions (e.g., shRNA, immunoresponsive cells expressing shRNA and/or a chimeric antigen receptors (CAR)), and methods of use thereof.

Abstract: The present disclosure provides a steering system of an engineering vehicle, and a backhoe loader. The steering system includes: a direction control device, including a steering wheel, a steering cylinder and steerable wheels, the steering cylinder being in transmission connection with the steering wheel and the steerable wheels; a displacement sensor configured to detect a piston displacement of the steering cylinder; a return motor in transmission connection with the steerable wheels to drive the steerable wheels to return to a normal position; and a controller in signal connection with the displacement sensor and the return motor, and configured to output a control signal according to the piston displacement detected by the displacement sensor to manipulate the return motor to drive the steerable wheels to return. The backhoe loader includes the steering system.

Abstract: The present disclosure provides, in part, methods of discovering immunotherapy targets in vivo, therapeutic compositions (e.g., shRNA, immunoresponsive cells expressing shRNA and/or a chimeric antigen receptors (CAR)), and methods of use thereof.

Abstract: The present disclosure provides, in part, methods of discovering immunotherapy targets in vivo, therapeutic compositions (e.g., shRNA, immunoresponsive cells expressing shRNA and/or a chimeric antigen receptors (CAR)), and methods of use thereof.

Abstract: The present disclosure provides, in part, methods of discovering immunotherapy targets in vivo, therapeutic compositions (e.g., shRNA, immunoresponsive cells expressing shRNA and/or a chimeric antigen receptors (CAR)), and methods of use thereof.

Abstract: The present disclosure provides, in part, methods of discovering immunotherapy targets in vivo, therapeutic compositions (e.g., shRNA, immunoresponsive cells expressing shRNA and/or a chimeric antigen receptors (CAR)), and methods of use thereof.

Abstract: The present disclosure provides, in part, methods of discovering immunotherapy targets in vivo, therapeutic compositions (e.g., shRNA, immunoresponsive cells expressing shRNA and/or a chimeric antigen receptors (CAR)), and methods of use thereof.