Abstract: The present invention provides a non-clottable matrix on a solid support comprising immobilized and crosslinked fibrinogen. The matrix may further comprise, in and/or on the matrix, one or several biologically active compound(s) and/or pharmacological substance(s). The matrix may be composed of one or several fibrinogen layer(s). The solid support according to the present invention may be selected from the group consisting of orthopaedic devices, implants, stitches, stents, pins, screws, plates, and sutures.

Abstract: Disclosed is a coated suture thread comprising a matrix formed by an immobilized and crosslinked plurality of fibrinogen layers into and/or onto which one or several pharmacological substances that inhibit tissue break-down, such as MMP inhibitors and/or corticosteroids and/or COX inhibitors, are attached and/or associated. Further, a method of producing such a coated suture thread as well as the use thereof for suturing damaged tissue, such as damaged tendon, ligament, intestine and/or skin, are described.

Abstract: The method of the present invention is for coating an implant device. The implant device is coated with a protein film, such as fibrinogen. A first bisphosphonate substance, such as pamidronate, is immobilized to the protein film. A second bisphosphonate substance, such ibandronate, is adsorbed to the first bisphosphonate wherein the first bisphosphonate is different from the second bisphosphonate.

Abstract: The method of the present invention is for coating a suture thread. The suture thread is coated with a protein film, such as fibrinogen. An active enzyme inhibitor, such as a matrix metallo proteinase inhibitor, is immobilized to or associated with the film.

Abstract: An analytical method of qualitative and optionally quantitative determination of the occurrence of polymerization/coagulation in a fluid containing polymerizable/coagulable components is described. The method comprises the steps of directing incident beams of electromagnetic radiation through a transparent support on which a film of electrically conducting material is placed, to the back of the film, at angles equal to or greater than the critical angle for total reflection, and measuring changes in the reflected beams due to changes in the surface plasmon resonance angle. Repeated measurements are correlated to the occurrence and magnitude of changes with qualitative and optionally quantitative occurrence of polymerization/coagulation in the fluid. The analytical method is not volume dependent since only one (small) surface of the measuring instrument needs to be in contact with the fluid. Further, the method can also be applied to poorly transparent fluids such as blood.

Abstract: A method of preparing an implant body in order to optimize the healing time of said implant, comprising bringing the implant body for a limited period of time into contact with a hydrogen peroxide solution at least on the surfaces intended to come into contact with surrounding tissue when implanted, the treated surfaces being cleaned by rinsing. The treatment of the implant surface with hydrogen peroxide can be supplemented with incorporation of biomolecules, such as peptides, proteins and steroids, and also other substances such as inorganic ions and crystals. The compounds to be coupled to the implant surface may promote the healing and/or binding of the surrounding tissue.

Abstract: The reaction product of H.sub.2 O.sub.2 and metallic titanium, a titanium peroxy radical gel, exhibits oxidizing and anti-inflammatory effects and is used, for instance, as a biocompatible oxidant, an anti-inflammatory agent or in vitro coating of an implant body. The gel-like product is produced by treating metallic titanium with H.sub.2 O.sub.2.