Patents by Inventor Per Antonius Foss

Per Antonius Foss has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Contrast agents
    Publication number: 20010019710
    Abstract: Oil-in-water emulsions in which the oil phase comprises condensed or dissolved oil-soluble gas/fluid or gas precursor are useful as ultrasound contrast agents. Such products contain insignificant amounts of free gas bubbles or microbubbles in their stored form and exhibit good stability, but may be designed to promote rapid microbubble generation immediately before or upon administration.
    Type: Application
    Filed: December 5, 2000
    Publication date: September 6, 2001
    Applicant: NYCOMED IMAGING AS
    Inventors: Arne Berg, Harald Dugstad, Per Antonius Foss, Jo Klaveness, Jonny Ostensen, Pal Rongved, Per Strande
  • Dry microparticles for use as a contrast agent
    Patent number: 6274120
    Abstract: Microparticulate contrast agents comprising gas or a gas precursor encapsulated by a non-polymeric and non-polymerisable wall-forming material are readily characterisable materials exhibiting surprising structural integrity and stability.
    Type: Grant
    Filed: October 14, 1999
    Date of Patent: August 14, 2001
    Assignee: Nycomed Imaging AS
    Inventors: Harald Dugstad, Per Antonius Foss, Jo Klaveness, Pål Rongved, Roald Skurtveit, Jan Solberg, Inger Reidun Fjeldskaar Aukrust
  • Polymeric surfactant-encapsulated microbubbles and their use in ultrasound imaging
    Patent number: 5919434
    Abstract: The present invention relates to polymer-based gas-containing contrast agents in which microbubbles of gas are encapsulated by non-polymerizable wall-forming block or graft copolymer surfactants. The polymer surfactants are preferably biodegradable and include block and graft copolymers containing linkages of formula (I):--(O).sub.m --CO--O--C(R.sup.1 R.sup.2)--O--CO--(O).sub.n --(I)where R.sup.1 and R.sup.2 each represent a hydrogen atom or a carbon-attached monovalent organic group, or R.sup.1 and R.sup.2 together form a carbon-attached divalent organic group and m and n are each zero or 1.
    Type: Grant
    Filed: March 14, 1997
    Date of Patent: July 6, 1999
    Assignee: Nycomed Imaging AS
    Inventors: Harald Dugstad, Per Antonius Foss, Jo Klaveness, P.ang.l Rongved, Roald Skurtveit
  • Microbubble-based contrast agents with crosslinked and reduced proteinaceous shells
    Patent number: 5718884
    Abstract: The present invention pertains to proteinaceous gas- or gas precursor-containing microbubble contrast agents for use in ultrasound and/or MR imaging, in which the protein matrix is crosslinked by reaction with a bifunctional aldehyde (e.g., a dialdehyde such as glutaraldehyde or an .alpha.,.beta.-unsaturated aldehyde such as acrolein) in an aqueous medium at substantially neutral pH. The contrast agents exhibit improved in vivo and storage stabilities, particularly if the matrix is also reacted with a Schiff's base reducing agent such as a borohydride. Modification of the size distribution of such crosslinked proteinaceous gas-containing contrast agents, e.g. to reduce the mean size of the microbubbles, further enhances their stability and permits preparation of novel contrast agents having a particularly narrow microbubble size distribution.
    Type: Grant
    Filed: May 4, 1995
    Date of Patent: February 17, 1998
    Assignee: Nycomed Imaging AS
    Inventors: Jo Klaveness, Pal Rongved, John Henrik Johansen, Per Antonius Foss, Anders H.o slashed.gset, Anne Marie Hvoslef