Abstract: A nasal delivery device comprising: a housing (15); a nosepiece (17) for fitting to a nasal cavity of a subject; a mouthpiece (19) through which the subject in use exhales; and a substance supply unit (21) including an actuation member (23) which extends from one end of the housing and is manually actuated to deliver substance to the nasal cavity of the subject; wherein the housing includes a grip section (27) which is disposed at the one end of the housing from which the actuation member extends, said grip section comprising a first, distal part (28) including at least one projecting grip element (29) by which the subject grips the housing in actuating the actuation member, and a second, proximal part (31) providing a recess (33) in which fingers of the subject are located, said recess promoting proper orientation of the delivery device in a hand of the subject.

Abstract: The invention relates to an apparatus for collection of airway gases from a subject comprising a first means for producing closure of the velum of the subject, and a second means for collection of the airway gases, wherein the first and second means need not be integral with each other.

Abstract: The invention relates to an apparatus for collection of airway gases from a subject comprising a first means for producing closure of the velum of the subject, and a second means for collection of the airway gases, wherein the first and second means need not be integral with each other.

Abstract: A delivery device, in particular a breath-actuated nasal delivery device, for delivering substance, in particular one of a liquid, as a suspension or solution, or a powder containing a medicament, especially systemic or topical pharmaceuticals, or a vaccine to the nasal airway of a subject.

Abstract: A delivery device for and method of delivering substance, the delivery device comprising: an outlet member through which substance is in use delivered in an entraining gas flow; and a substance supply unit for supplying substance to be entrained by an entraining gas flow as one or both of a vapor or a fine aerosol mist, wherein the substance supply unit comprises a flow channel which is fluidly connected to the outlet member, and a substance supporting element for supporting substance, at least a surface of which is in use disposed in the flow channel.

Abstract: A delivery device for and method of delivering substance, in particular a vaccine, to a mucosal surface within the oral cavity of a subject, the device comprising: a mouthpiece unit to be gripped in the mouth of a subject, wherein the mouthpiece unit is configured such that, on exhalation or attempted exhalation by the subject, a pressure is developed in the oral cavity which is such as to close the oropharyngeal velum of the subject; and an oral outlet unit including at least one outlet from which substance is in use delivered to a mucosal surface within the oral cavity of the subject.

Abstract: A delivery device (20, 22) for and a method of delivering a substance to the nasal airway (1) of a subject, in particular the posterior region of the nasal airway, the delivery device comprising: a closure unit for causing the closure of the oropharyngeal velum of the subject; and a delivery unit for delivering a gas flow entraining a substance to one of the nostrils of the subject at such a driving pressure as to flow around the posterior margin of the nasal septum and out of the other nostril of the subject, wherein the delivery unit comprises a nosepiece (30, 40, 58, 82, 102, 132) which includes an outlet through which the gas flow is in use delivered to the one nostril and a sealing member for sealing the one nostril to the outlet such as in use to prevent the escape of the gas flow through the one nostril.

Abstract: A delivery device (20, 22) for and a method of delivering a substance to the nasal airway (1) of a subject, in particular the posterior region of the nasal airway, the delivery device comprising: a closure unit for causing the closure of the oropharyngeal velum of the subject; and a delivery unit for delivering a gas flow entraining a substance to one of the nostrils of the subject at such a driving pressure as to flow around the posterior margin of the nasal septum and out of the other nostril of the subject, wherein the delivery unit comprises a nosepiece (30, 40, 58, 82, 102, 132) which includes an outlet through which the gas flow is in use delivered to the one nostril and a sealing member for sealing the one nostril to the outlet such as in use to prevent the escape of the gas flow through the one nostril.

Abstract: A delivery device (20, 22) for and a method of delivering a substance to the nasal airway (1) of a subject, in particular the posterior region of the nasal airway, the delivery device comprising: a closure unit for causing the closure of the oropharyngeal velum of the subject; and a delivery unit for delivering a gas flow entraining a substance to one of the nostrils of the subject at such a driving pressure as to flow around the posterior margin of the nasal septum and out of the other nostril of the subject, wherein the delivery unit comprises a nosepiece (30, 40, 58, 82, 102, 132) which includes an outlet through which the gas flow is in use delivered to the one nostril and a sealing member for sealing the one nostril to the outlet such as in use to prevent the escape of the gas flow through the one nostril.

Abstract: A delivery device (20, 22) for and a method of delivering a substance to the nasal airway (1) of a subject, in particular the posterior region of the nasal airway, the delivery device comprising: a closure unit for causing the closure of the oropharyngeal velum of the subject; and a delivery unit for delivering a gas flow entraining a substance to one of the nostrils of the subject at such a driving pressure as to flow around the posterior margin of the nasal septum and out of the other nostril of the subject, wherein the delivery unit comprises a nosepiece (30, 40, 58, 82, 102, 132) which includes an outlet through which the gas flow is in use delivered to the one nostril and a sealing member for sealing the one nostril to the outlet such as in use to prevent the escape of the gas flow through the one nostril.

Abstract: A delivery device for and method of delivering substance, the delivery device comprising: a delivery outlet (7) from which substance (5) is in use delivered; a gas chamber (17) containing a gas and being of reducible volume, wherein a reduction in the volume of the gas chamber (17) to a predeterminable volume acts to pressurize the contained gas to a predeterminable pressure; a seal element (11) disposed between the gas chamber (17) and the delivery outlet (7); and an opening mechanism configured, on reduction of the volume of the gas chamber to a predeterminable volume, to open the seal element (11), whereupon a gas flow from the gas chamber (17) acts to deliver substance (5) from the delivery outlet (7).

Abstract: A nasal delivery device for and a method of delivering substance to a nasal airway of a subject, in particular in the mass treatment, especially mass vaccination, of subjects, the delivery device comprising: an interface unit, as a replaceable unit, including at least one nosepiece unit for fitting to a respective nostril of a subject and including a nozzle from which substance is in use delivered, and at least one delivery unit including a substance supply unit for delivering substance to the nozzle of the at least one nosepiece unit; and an actuation unit for actuating the at least one delivery unit of the interface unit.

Abstract: A nasal delivery device for and method of delivering substance to a nasal airway of a subject, the delivery device comprising: a nosepiece for fitting to a nostril of a subject; a delivery unit comprising a substance supply unit and a nozzle unit including at least one nozzle fluidly connected to the substance supply unit for generating an aerosol spray for delivery to a nasal airway of the subject; and an aerosol interactor operable to interact with an aerosol spray as generated by the at least one nozzle.

Abstract: A nasal delivery device (11) for delivering substance to a nasal airway (1) of a subject, comprising: first and second nosepiece units (17, 19), each including a nosepiece (21, 23) for fitting to respective nostrils of a subject; at least one substance supply unit (13, 15) for supplying substance for delivery to the nasal airway (1) of the subject; and a valve unit (35, 37) for selectively fluidly connecting the at least one substance supply unit (13, 15) alternately to respective ones of the nosepiece units (17, 19).

Abstract: The invention relates to an apparatus for collection of airway gases from a subject comprising a first means for producing closure of the velum of the subject, and a second means for collection of the airway gases, wherein the first and second means need not be integral with each other.