Patents by Inventor Per EDEBRINK

Per EDEBRINK has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Combination of TIS sequence and signal peptide sequence for expressing a recombinant protein
    Patent number: 12584143
    Abstract: The present invention relates to DNA constructs comprising a novel TIS sequence. The TIS sequence transcribes into an RNA motif that functions as the protein translation initiation site in an mRNA transcript. The DNA construct may further comprise a nucleic acid sequence encoding signal peptide. Additionally, the DNA constructs may also comprise a nucleic acid sequence encoding a recombinant protein or one or more polypeptide chains thereof. The invention further relates to an expression vector, expression cassette and host cell which comprise said DNA constructs. Furthermore, the present invention relates to a recombinant protein expressed by the host cell as well as a method for expressing the recombinant protein.
    Type: Grant
    Filed: March 17, 2021
    Date of Patent: March 24, 2026
    Assignee: XBRANE BIOPHARMA AB
    Inventors: Kiavash Mirzadeh, Veronica Ramberg, Nathalie Chatzissavidou, Patrik Samuelson, Siavash Bashiri, Per Edebrink, Joanne Stevenson, David Vikstrom
  • DNA CONSTRUCTS AND HOST CELLS FOR EXPRESSING RECOMBINANT PROTEIN
    Publication number: 20250368732
    Abstract: A DNA construct for expressing a recombinant protein, wherein the DNA construct comprises: —at least one of the nucleotide sequences of SEQ ID No 20 and 21, wherein a nucleotide sequence of SEQ ID 20 and 21 is a TIR sequence; and —a nucleotide sequence which encodes a signal peptide; and wherein a nucleotide sequence of SEQ ID No 20 and 21 comprises at least the first 9 nucleotides of said signal peptide encoding sequence.
    Type: Application
    Filed: September 23, 2022
    Publication date: December 4, 2025
    Applicants: Xbrane Biopharma AB, Alvotech HF
    Inventors: Kiavash Mirzadeh, David Vikström, Nurzian Ismail, Patrik Samuelson, Mariusz Baraszkiewicz, Tagrid Salih, Kathleen Szekér, Daniel Chui, Santhosh Gudise, Per Edebrink, Maria Kadow, Karin Stefansson, Kristin Strandberg
  • NOVEL COMBINATION OF TIS SEQUENCE AND SIGNAL PEPTIDE SEQUENCE FOR EXPRESSING A RECOMBINANT PROTEIN
    Publication number: 20230175008
    Abstract: The present invention relates to DNA constructs comprising a novel TIS sequence. The TIS sequence transcribes into an RNA motif that functions as the protein translation initiation site in an mRNA transcript. The DNA construct may further comprise a nucleic acid sequence encoding signal peptide. Additionally, the DNA constructs may also comprise a nucleic acid sequence encoding a recombinant protein or one or more polypeptide chains thereof. The invention further relates to an expression vector, expression cassette and host cell which comprise said DNA constructs. Furthermore, the present invention relates to a recombinant protein expressed by the host cell as well as a method for expressing the recombinant protein.
    Type: Application
    Filed: March 17, 2021
    Publication date: June 8, 2023
    Applicant: XBRANE BIOPHARMA AB
    Inventors: Kiavash MIRZADEH, Veronica RAMBERG, Nathalie CHATZISSAVIDOU, Patrik SAMUELSON, Siavash BASHIRI, Per EDEBRINK, Joanne STEVENSON, David VIKSTROM