Abstract: A closure device for sealing a percutaneous puncture in the wall of a blood vessel includes: an insertion tool having an actuator which is operable in a first mode in which the actuator is configured for deployment of an inner seal inside the vessel and operable in a second mode in which the actuator is configured for tamping a locking member on an outside of the vessel, where the actuator is arranged to be set into the second mode in response to a pulling force acting on a filament connecting the inner seal and the locking member.

Abstract: A medical sealing device for the sealing of a puncture hole in a vessel wall includes an inner member, which is adapted to be positioned at an interior surface of the vessel wall, and an outer member, which is adapted to be positioned outside the vessel wall, the inner member and the outer member being held together by a retaining member. The sealing device further includes a sealing element, which is adapted to be positioned between the vessel wall and the outer member to improve the sealing performance of the sealing device.

Abstract: The invention provides a puncturing guide (1, 16) for guiding a puncturing needle into a target site within the body of a patient. The puncturing guide (1, 16) comprises a base plate (2, 17), a needle guide (3, 18), a retainer (4, 19) for securing the needle guide (3, 18) to the base plate (2, 17), a first segment (7, 20) of a first semi-sphere, a second segment (8, 21) of a second semi-sphere, and a needle guide (3, 18) attached to the second segment (8, 21). During a positioning operation, the second segment (8, 21) slides on the first segment (7, 20), so that the needle guide (3, 18) is movable around the center of the first semi-sphere, which is in level with the underside of the base plate (2, 17), thereby providing the possibility to position the tip of a puncturing needle at a puncturing point on the patient's skin and then, in a separate operation, set the entrance angle of the puncturing needle without changing its entrance point.

Abstract: An indicator device for visually indicating a pressure of blood inside a blood vessel includes: a body, the body comprising a duct extending in the body and having a sealed proximal end; a distal end portion adapted to be positioned inside the blood vessel and including a liquid inlet opening in fluid communication with the duct; and a window including an at least semi-transparent section configured to enable visual observation of blood entering into the duct via the inlet opening when the inlet opening is located inside the blood vessel.

Abstract: A femoral compression device (1; 41; 51; 61) for compressing a femoral artery of a patient is provided. The femoral compression device (1; 41; 51; 61) comprises a pressure device (7; 21; 31; 42; 55; 62), a compression member (8; 43; 56; 65) for compressive bearing against a puncture site, a base portion (3; 44; 52) provided with two opposing extensions (4, 5; 45, 46; 53, 54), to the ends of which a belt (6), which is adapted to be arranged around the patient's body, can be fixed. According to the invention, the pressure device (7; 21; 31; 42; 55; 62) is characterized by non-uniform overall action constants, such that when a low compression pressure is applied, the pressure device (7; 21; 31; 42; 55; 62) exhibits a small action constant, and when a high compression pressure is applied, the pressure device (7; 21; 31; 42; 55; 62) exhibits a large action constant.

Abstract: The invention provides a femoral compression device (11; 21) for compressing a femoral artery of a patient. The femoral compression device (11; 21) comprises a pressurizing means (12; 22), a compression plate (13; 23) for compressive bearing against a puncture site, a base portion (14; 24) provided with two opposing extensions (15, 16; 25, 26), to the ends of which a belt, which is adapted to be arranged around the patient's body, can be fixed. According to the invention, the pressurizing means is in the form of a spring (12; 22), such as a coil spring (12; 22), the first end of which is connected to the compression plate (13; 23) and the second end of which is operatively connected to a handle (19; 29), which can be operated to adjusting the compression of the spring (12; 22).

Abstract: The invention provides a method for replacing a first introducer, whose distal end is inside a vessel and whose proximal end is outside the skin of a patient, with a second introducer. The method comprises the steps of inserting a guide rod into the first introducer, removing the first introducer, passing the second introducer over the guide rod, and removing the guide rod. The guide rod to be used according to the method has preferably a flexible distal portion with a blunt distal end and a stiff proximal portion with a tapered proximal end.

Abstract: An absorbable crystalline, monocentric polyaxial copolymer comprising a central carbon or nitrogen atom and at least three axes, each of which includes an amorphous flexible component adjacent and originating from the central atom and a rigid, crystallizable component extending outwardly from the amorphous, flexible component is disclosed along with the use of such copolymer in medical devices which may contain a bioactive agent. The present invention also relates to a suture, stents, stent mantles and sealing devices made from the polyaxial copolymer.

Abstract: The invention relates to a loading device provided with a tamping mechanism with which two or three functional operations needed in the sealing of punctures in blood vessels can be sequentially executed in one single manual operation. In a preferred embodiment of the tamping mechanism, a cam curve (15) transforms the single manual operation of a tamping button (8) being the one end of a plunger (14) into the retraction of a pusher (5), which has been used to insert an inner seal (1) into the vessel, and, then, the advancement of a tamping tube (10), which pushes an outer seal (2) into engagement with the outer vessel wall. In the end position of the tamping button (8), a recess (23) in the plunger (14) releases a thread (3), which tamps the inner and outer seals (1, 2) together around the intermediate vessel wall, from a retainer (16), thereby completing the third operation step.

Abstract: The present invention provides a medical sealing device having a decreased risk that a fastening means, such as a suture or a multifilament, ruptures through the sealing device. An absorbable medical sealing device (3; 10; 15) according to the present invention is provided with one or more recesses (6, 7; 13; 18) for fastening means (5; 14; 17) and is characterized in that the sealing device (3; 10; 15) comprises a base portion (8; 11; 16), which is made of a first material having a lower modulus, and a reinforcement portion (9; 12; 19), which is made of second material having a higher modulus, the reinforcement portion (9; 12; 19) being provided to reinforce said recesses (6, 7; 13; 18).

Abstract: A guiding tool for controllable and reversible folding or deformation of a wound closure element before insertion into a percutaneous incision or puncture in the wall of e.g. a blood vessel, said incision or puncture being smaller than said wound closure element in an unfolded or undeformed state. It comprises a tubular member having a lumen. The lumen has inner walls provided with wound closure element guiding surfaces, adapted to reversibly reduce the spatial extension of a wound closure element during its passage through the guiding tool. A system for the introduction and securing of a wound closure element into a percutaneous incision or puncture in the wall of a vessel comprises such a guiding tool.

Abstract: An intra-arterial occluder according to the invention exhibits a central elongated portion being comparatively stiff, e.g., by being thicker, and an outer rim portion being more flexible. The occluder is passed through the puncture, and is oriented such that the axis of the central portion is generally coaxial with the vessel. When retracted, the central portion will rest against the vessel wall at two diametrically opposed areas around the puncture, and along the length of the vessel. These areas represent the strongest areas around the puncture, and will therefore be able to safely carry the retracting force. At the same time, the thinner circumferential rim portion, which is easily foldable to fit into an insertion tool, adapts to the vessel wall and acts as an efficient sealing.

Abstract: The invention relates to an air cushion unit (2) of single use type for stopping bleeding. The unit (2) comprises a base plate (4) and an inflatable air cushion (8) attached to the base plate (4). The air cushion (8) comprises a reinforced portion (16), integral with the cushion surface, and extending radially along the inside of the cushion, and corresponding to an area of contact with a wound site.

Abstract: The present invention provides a medical sealing device having a decreased risk that a fastening means, such as a suture or a multifilament, ruptures through the sealing device. An absorbable medical sealing device (3; 10; 15) according to the present invention is provided with one or more recesses (6, 7; 13; 18) for fastening means (5; 14; 17) and is characterized in that the sealing device (3; 10; 15) comprises a base portion (8; 11; 16), which is made of a first material having a lower modulus, and a reinforcement portion (9; 12; 19), which is made of second material having a higher modulus, the reinforcement portion (9; 12; 19) being provided to reinforce said recesses (6, 7; 13; 18).

Abstract: An intra-arterial occluder according to the invention exhibits a central elongated portion being comparatively stiff, e.g., by being thicker, and an outer rim portion being more flexible. The occluder is passed through the puncture, and is oriented such that the axis of the central portion is generally coaxial with the vessel. When retracted, the central portion will rest against the vessel wall at two diametrically opposed areas around the puncture, and along the length of the vessel. These areas represent the strongest areas around the puncture, and will therefore be able to safely carry the retracting force. At the same time, the thinner circumferential rim portion, which is easily foldable to fit into an insertion tool, adapts to the vessel wall and acts as an efficient sealing.

Abstract: The invention relates to a device for performing hemostasis at two symmetrically located puncture sites in the femoral arteries or veins of a patient. It comprises a beam member (6, 8) provided with two attachment devices (10, 12) for pressure pads. There are belts for securing the device to the patient to provide a pressure on the puncture sites, and means (18, 20, 24, 26) for adjusting the distance between said attachment. The invention also provides a method of controlled hemostasis at two puncture sites in each femoral artery or vein of a patient after catheterization, comprising providing a beam member having two pressure pads, adapted to bear against each puncture site, adjusting the center-to-center distance of said pressure pads by moving at least one of said pressure pads along said beam member, applying said pressure pads at said puncture sites, securing said beam member carrying said pressure pads to the body of said patient, by tightening a belt around the body.

Abstract: A guide wire for intravascular investigations includes an elongated element, and electrical conductors extending along a length of the guide wire. A portion of one of the electrical conductors is provided as a layer of electrically conductive material, extending concentrically over the circumference of, and along the elongated element forming a part of the guide wire.A method of manufacturing a conductor element for a guide wire with conductors in the form of a layer of a conductive material extending along the length of the conductor element is provided. A core element is provided. Overlapping layers of alternating insulating and conductive materials are applied concentrically around the circumference of the core element along a portion of its length, until a desired number of conductive layers have been applied.

Abstract: The present invention relates to a guide wire, comprising a core wire (4) having a proximal and a distal end. There is at least one electrical lead (10a, 10b, 10c) provided on said core wire and extending along the length thereof, connecting to an electrical device (6) provided at the distal end of said core wire. A male connector is provided at the proximal end of said core wire, and a protective tubing (not shown) covers the core wire and the leads. The leads are formed on a sheet (14) of a thin, flexible material, said sheet being at least partially wrapped around said core wire along the length thereof. The flexible sheet has a wider portion (18) at the proximal end, and is wrapped at least one full turn around the proximal end of said core wire. The wider portion has at least one conductive strip (8a, 8b, 8c) extending over said portion in the transverse direction.