Patents by Inventor Per Gisle Djupesland
Per Gisle Djupesland has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230381097Abstract: A nasal delivery device for and method of delivering a substance, preferably comprising oxytocin, non-peptide agonists thereof and antagonists thereof, preferably as one of a liquid, as a suspension or solution, or a powder, to the nasal airway of a subject, preferably the posterior region of the nasal airway, and preferably the upper posterior region of the nasal airway which includes the olfactory bulb and the trigeminal nerve, and preferably in the treatment of neurological conditions and disorders.Type: ApplicationFiled: May 2, 2023Publication date: November 30, 2023Inventor: Per Gisle DJUPESLAND
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Publication number: 20230372647Abstract: A nosepiece for delivering substance to a nasal cavity of a subject, the nosepiece comprising a body part which comprises a base portion which defines a flow passage therethrough, and a projection at a distal end of the base portion which at least in part provides a tip of the nosepiece and confers a rigidity in the sagittal direction, which enables the tip to open fleshy tissue at an upper region of the nasal valve and thereby expand an open area of the nasal valve, and a flexibility in a lateral direction, orthogonal to the sagittal plane, which facilitates insertion of the tip into the nasal valve.Type: ApplicationFiled: June 5, 2023Publication date: November 23, 2023Inventors: Per Gisle DJUPESLAND, Colin David SHELDRAKE
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Patent number: 11730904Abstract: A delivery device for and method of modulating a condition relating to social cognition and/or behaviour in a human subject using oxytocin, non-peptide agonists thereof and/or antagonists thereof, comprising: providing a nosepiece to a first nasal cavity of the subject; and providing a supply unit for administering less than 24 IU of oxytocin, non-peptide agonists thereof and/or antagonists thereof through the nosepiece to an upper region posterior of the nasal valve which is innervated by the trigeminal nerve.Type: GrantFiled: June 4, 2021Date of Patent: August 22, 2023Assignee: OptiNose, Inc.Inventors: Per Gisle Djupesland, Ramy A. Mahmoud, Ole A Andreassen, Lars T. Westlye, Daniel S. Quintana, Knut T. Smerud, Colin David Sheldrake
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Publication number: 20230248925Abstract: A nasal delivery device for and a method of delivering substance to a nasal airway of a subject, the nasal delivery device comprising: a mouthpiece (519) through which the subject in use exhales to cause closure of the oropharyngeal velum of the subject; a nosepiece (517) for fitting to a nostril of a subject, the nosepiece including a nozzle (549) through which substance is in use delivered to the nasal airway; and a manually-actuatable substance supply unit (520) for delivering substance through the nozzle of the nosepiece.Type: ApplicationFiled: February 14, 2023Publication date: August 10, 2023Inventors: Per Gisle DJUPESLAND, Colin David SHELDRAKE
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Patent number: 11707586Abstract: A nosepiece for delivering substance to a nasal cavity of a subject, the nosepiece comprising a body part which comprises a base portion which defines a flow passage therethrough, and a projection at a distal end of the base portion which at least in part provides a tip of the nosepiece and confers a rigidity in the sagittal direction, which enables the tip to open fleshy tissue at an upper region of the nasal valve and thereby expand an open area of the nasal valve, and a flexibility in a lateral direction, orthogonal to the sagittal plane, which facilitates insertion of the tip into the nasal valve.Type: GrantFiled: January 29, 2021Date of Patent: July 25, 2023Assignee: OptiNose Inc.Inventors: Per Gisle Djupesland, Colin David Sheldrake
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Patent number: 11690969Abstract: A delivery device for and a method of delivering gases to the nasal airway, in particular therapeutic gases and gases in combination with active substances, either as powders or liquids, for enhanced uptake of the active substances.Type: GrantFiled: August 6, 2020Date of Patent: July 4, 2023Assignee: OptiNose Inc.Inventors: Per Gisle Djupesland, Roderick Peter Hafner
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Publication number: 20230181849Abstract: A nasal delivery device for delivering substance to a nasal cavity of a subject, the delivery device comprising: a substance supply unit for supplying a dose of substance to be delivered to the nasal cavity of the subject, the substance supply unit including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the substance supply unit; and a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the substance supply unit and through which the subject in use exhales such as to entrain substance from the container chamber and deliver the same through the nosepiece, and at least one temperature modifier for reducing a temperature of the exhaled air flow such as to reduce the absolute humidity thereof.Type: ApplicationFiled: February 6, 2023Publication date: June 15, 2023Applicant: OptiNose, Inc.Inventors: Per Gisle DJUPESLAND, Roderick Peter HAFNER, Colin David SHELDRAKE
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Publication number: 20230166061Abstract: A method of delivering a substance, such as one or more of a triptan, a nasal steroid or carbon dioxide gas, to the nasal cavity of a subject, in particular for the treatment of headaches, for example, migraine, or rhinosinusitis, for example, chronic rhinosinusitis, optionally with polyps, the method comprising the steps of fitting a nosepiece to one nostril of the subject, delivering the substance through the nosepiece to the posterior region of the nasal cavity of the subject.Type: ApplicationFiled: December 12, 2022Publication date: June 1, 2023Inventors: Per Gisle DJUPESLAND, Ramy A. MAHMOUD, John MESSINA
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Patent number: 11602603Abstract: A nasal delivery device for and a method of delivering substance to a nasal airway of a subject, the nasal delivery device comprising: a mouthpiece (519) through which the subject in use exhales to cause closure of the oropharyngeal velum of the subject; a nosepiece (517) for fitting to a nostril of a subject, the nosepiece including a nozzle (549) through which substance is in use delivered to the nasal airway; and a manually-actuatable substance supply unit (520) for delivering substance through the nozzle of the nosepiece.Type: GrantFiled: July 2, 2021Date of Patent: March 14, 2023Assignee: OptiNose, Inc.Inventors: Per Gisle Djupesland, Colin David Sheldrake
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Patent number: 11571531Abstract: A nasal delivery device for delivering substance to a nasal cavity of a subject, the delivery device comprising: a substance supply unit for supplying a dose of substance to be delivered to the nasal cavity of the subject, the substance supply unit including an inlet and an outlet; a nosepiece unit including a nosepiece for fitting to a nasal cavity of the subject and being in fluid communication with the outlet of the substance supply unit; and a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the substance supply unit and through which the subject in use exhales such as to entrain substance from the container chamber and deliver the same through the nosepiece, and at least one temperature modifier for reducing a temperature of the exhaled air flow such as to reduce the absolute humidity thereof.Type: GrantFiled: January 24, 2018Date of Patent: February 7, 2023Assignee: OptiNose Inc.Inventors: Per Gisle Djupesland, Roderick Peter Hafner, Colin David Sheldrake
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Patent number: 11554229Abstract: A method of delivering a substance, such as one or more of a triptan, a nasal steroid or carbon dioxide gas, to the nasal cavity of a subject, in particular for the treatment of headaches, for example, migraine, or rhinosinusitis, for example, chronic rhinosinusitis, optionally with polyps, the method comprising the steps of fitting a nosepiece to one nostril of the subject, delivering the substance through the nosepiece to the posterior region of the nasal cavity of the subject.Type: GrantFiled: June 25, 2014Date of Patent: January 17, 2023Assignee: OptiNose Inc.Inventors: Per Gisle Djupesland, Ramy A. Mahmoud, John Messina
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Publication number: 20220347092Abstract: A nasal delivery device for and method of delivering a substance, preferably comprising oxytocin, non-peptide agonists thereof and antagonists thereof, preferably as one of a liquid, as a suspension or solution, or a powder, to the nasal airway of a subject, preferably the posterior region of the nasal airway, and preferably the upper posterior region of the nasal airway which includes the olfactory bulb and the trigeminal nerve, and preferably in the treatment of neurological conditions and disorders.Type: ApplicationFiled: February 18, 2022Publication date: November 3, 2022Inventor: Per Gisle DJUPESLAND
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Publication number: 20220296825Abstract: An exhalation delivery system for and method of treating a patient having sinus disease, comprising, following Draf 2 or Draf 3 surgery, administering a therapeutic agent including a corticosteroid to the patient, wherein the therapeutic agent is administered by an exhalation delivery device comprising a mouthpiece and a nosepiece, fitting the nosepiece to a first nostril of the patient, and the patient exhaling into the mouthpiece to create a fluid flow out of the nosepiece and into the first nostril during administration of the therapeutic agent to the patient.Type: ApplicationFiled: October 4, 2019Publication date: September 22, 2022Inventors: Per Gisle DJUPESLAND, John MESSINA
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Publication number: 20220273894Abstract: A nasal delivery device for and method of delivering particulate substance to the nasal airway of a subject, the delivery device comprising: a body assembly including a mouthpiece unit which includes a mouthpiece through which the subject in use exhales, and a substance-supply unit which is fluidly connected to the mouthpiece unit and actuatable to provide particulate substance for delivery to the nasal airway of the subject; wherein the body assembly is configured to receive a replaceable nosepiece unit which includes a nosepiece and contains a container containing particulate substance.Type: ApplicationFiled: March 14, 2022Publication date: September 1, 2022Inventors: Per Gisle DJUPESLAND, Colin David SHELDRAKE, Simon SMITH, Rachel STRIEBIG, Andy PIDGEON, Tom ST. QUINTIN
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Publication number: 20220152324Abstract: A nasal delivery device for delivering substance to a nasal cavity of a subject comprises: a housing (15); a nosepiece (17) for fitting to a nasal cavity of the subject: a mouthpiece (19) through which the subject in use exhales; and a flexible coupling (20) which couples the mouthpiece to the housing, wherein the flexible coupling provides for asymmetric translation of the mouthpiece relative to the nosepiece.Type: ApplicationFiled: July 2, 2021Publication date: May 19, 2022Inventors: Per Gisle DJUPESLAND, Joseph GORDON, Michael LECLERC, Ramy A. MAHMOUD, Shane SIWINSKI
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Patent number: 11291626Abstract: A nasal delivery device for and method of delivering a substance, preferably comprising oxytocin, non-peptide agonists thereof and antagonists thereof, preferably as one of a liquid, as a suspension or solution, or a powder, to the nasal airway of a subject, preferably the posterior region of the nasal airway, and preferably the upper posterior region of the nasal airway which includes the olfactory bulb and the trigeminal nerve, and preferably in the treatment of neurological conditions and disorders.Type: GrantFiled: September 14, 2011Date of Patent: April 5, 2022Assignee: OptiNose ASInventor: Per Gisle Djupesland
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Publication number: 20220096763Abstract: A nasal delivery device for and method of delivering substance to a nasal cavity of a subject, the delivery device comprising: a nosepiece for fitting to a nostril of a subject, wherein the nosepiece comprises a tip element which includes a delivery aperture from which substance is in use delivered into the nasal cavity, and the tip element is at least in part tapered such as to be inclined to a longitudinal axis of the nosepiece, with the delivery aperture extending both laterally across the tip element and along a longitudinal extent of the tip element; a nozzle through which substance is in use delivered, preferably substantially axially to a longitudinal axis of the nosepiece, to the respective nasal cavity; and a delivery unit for delivering substance through the nozzle of the nosepiece.Type: ApplicationFiled: June 8, 2021Publication date: March 31, 2022Inventors: Per Gisle DJUPESLAND, Colin David SHELDRAKE
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Publication number: 20220031980Abstract: A nasal delivery device for and a method of delivering substance to a nasal airway of a subject, the nasal delivery device comprising: a mouthpiece (519) through which the subject in use exhales to cause closure of the oropharyngeal velum of the subject; a nosepiece (517) for fitting to a nostril of a subject, the nosepiece including a nozzle (549) through which substance is in use delivered to the nasal airway; and a manually-actuatable substance supply unit (520) for delivering substance through the nozzle of the nosepiece.Type: ApplicationFiled: July 2, 2021Publication date: February 3, 2022Inventors: Per Gisle DJUPESLAND, Colin David SHELDRAKE
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Publication number: 20210322690Abstract: A delivery device for and method of modulating a condition relating to social cognition and/or behaviour in a human subject using oxytocin, non-peptide agonists thereof and/or antagonists thereof, comprising: providing a nosepiece to a first nasal cavity of the subject; and providing a supply unit for administering less than 24 IU of oxytocin, non-peptide agonists thereof and/or antagonists thereof through the nosepiece to an upper region posterior of the nasal valve which is innervated by the trigeminal nerve.Type: ApplicationFiled: June 4, 2021Publication date: October 21, 2021Inventors: Per Gisle Djupesland, Ramy A. Mahmoud, Ole A. Andreassen, Lars T. Westlye, Daniel S. Quintana, Knut T. Smerud, Colin David Sheldrake
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Publication number: 20210290867Abstract: A nasal delivery device for and method of delivering substance to a nasal airway of a subject, the delivery device comprising: a nosepiece (117) for fitting to a nasal cavity of a subject, a mouthpiece (119) into which the subject in use exhales; a delivery unit, which comprises an actuation part which is manually displaceable to actuate the delivery unit to deliver substance from the nosepiece; and a valve assembly (127) which is fluidly connected to the nosepiece and the mouthpiece, wherein the valve assembly comprises a body element (128) and a valve element (131) which is movably disposed to the body element between closed and open configurations by manual displacement of the actuation part of the delivery unit to provide for an air flow through the nosepiece simultaneously with delivery of substance.Type: ApplicationFiled: May 11, 2021Publication date: September 23, 2021Inventors: Per Gisle DJUPESLAND, Michael LECLERC, Ramy A. MAHMOUD, Shane SIWINSKI, Joseph GORDON, Justin FISK