Abstract: The present disclosure relates to systems and methods for providing individualized prognostic assessments of breast cancer recurrence (e.g., locoregional recurrence). The systems and methods involve measuring gene expression from a patient sample to create a gene expression signature which identifies subjects who are not likely to benefit from radiotherapy following breast cancer surgery.

Abstract: The invention relates to a reversible torque converter which is intended as a auxiliary device for use in connection with pneumatic, electric and/or hand-operated tools or machines, or which is intended to be incorporated in such machines and tools as an integrated part thereof. The switching or change-over means comprises a radially acting coupling which includes a dogging plate (4) mounted on the input shaft (2), a dogging cage (8, 9) mounted on the output shaft (3), and coupling elements (23) which are active between the two dogging elements and which are arranged for movement between an inner position, corresponding to direct drive, and an outer position, corresponding to a gearing-down drive, when the outward shaft (3) is driven via a planetary gear system (7; 31, 32, 33; 34) which acts upon the coupling elements (8, 9). The coupling elements (23) are spring-biased (10, 11, 12) with a force which must be exceeded in order for a change-over to take place.