Patents by Inventor Per Kjellin
Per Kjellin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11536657Abstract: The present invention relates to a method for production of an improved sensor surface for an SPR instrument, comprising forming a self assembled monolayer (SAM) on a surface and attaching ligands and protein resistant groups, preferably polyethylene glycol (PEG), directly to functional groups on said surface. The invention also relates to a sensor surface produced by these methods use thereof in SPR (surface plasmon resonance) assays or interactions.Type: GrantFiled: June 7, 2018Date of Patent: December 27, 2022Assignee: Cytiva Sweden ABInventors: Lena Vinterback, Anna Lager, Per Kjellin, Tomas Dalmo
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Patent number: 11179725Abstract: A self-adhesive layered septum is disclosed. In one example, the septum includes a first outer layer including a thermoplastic elastomer such as a styrenic block copolymer, containing styrene ethylene butylene styrene (TPE-SEBS) capable of closing at least partially an aperture formed when a needle is inserted through the layer; an adhesive second layer for adhering the septum to a mouth area of a well or container to which the septum is attachable; and a thermoplastic third layer between the first and second layers, thermobonded to the first layer and providing better adherence for the adhesive layer. The first layer includes a recess and a vent, which reduce pressure differentials in use, but together with the third layer minimize evaporation through the septum.Type: GrantFiled: July 6, 2017Date of Patent: November 23, 2021Assignee: CYTIVA SWEDEN ABInventors: Hakan Erik Roos, Stefan Sjolander, Per Kjellin, Bharath Subrahmanya
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Publication number: 20210030921Abstract: This invention is directed to coated substrates, wherein the coating comprises titanium phosphate and/or zirconium phosphate. In certain embodiments the substrate is an implant for use in vivo. The invention is also directed to methods for forming coatings comprising or consisting of titanium phosphate and/or zirconium phosphate on the surface of a substrate.Type: ApplicationFiled: February 8, 2019Publication date: February 4, 2021Inventors: Per Kjellin, Fredrik Currie, Paul Handa, Line Vikingsson
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Publication number: 20200191715Abstract: The present invention relates to a method for production of an improved sensor surface for an SPR instrument, comprising forming a self assembled monolayer (SAM) on a surface and attaching ligands and protein resistant groups, preferably polyethylene glycol (PEG),directly to functional groups on said surface. The invention also relates to a sensor surface produced by these methods use thereof in SPR (surface plasmon resonance) assays or interactions.Type: ApplicationFiled: June 7, 2018Publication date: June 18, 2020Inventors: Lena Vinterback, Anna Lager, Per Kjellin, Tomas Dalmo
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Publication number: 20190308189Abstract: A self-adhesive layered septum is disclosed. In one example, the septum includes a first outer layer including a thermoplastic elastomer such as a styrenic block copolymer, containing styrene ethylene butylene styrene (TPE-SEBS) capable of closing at least partially an aperture formed when a needle is inserted through the layer; an adhesive second layer for adhering the septum to a mouth area of a well or container to which the septum is attachable; and a thermoplastic third layer between the first and second layers, thermobonded to the first layer and providing better adherence for the adhesive layer. The first layer includes a recess and a vent, which reduce pressure differentials in use, but together with the third layer minimize evaporation through the septum.Type: ApplicationFiled: July 6, 2017Publication date: October 10, 2019Inventors: Hakan Erik Roos, Stefan Sjolander, Per Kjellin, Bharath Subrahmanya
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Production of nanosized calcium phosphate particles as powder or coating via bifunctional precursors
Patent number: 9975772Abstract: Method of producing calcium phosphate particles, such as hydroxyapatite particles, in the form of a powder or coating on a solid support comprising an oxide surface or a polymer surface, such as titanium, titanium alloys, stainless steel, zirconia, glass and poly(styrene), poly(ether ether ketone) (PEEK), and poly(imide) is described. The method comprises I) providing a water solution containing calcium ions and water-soluble organic compound(s) comprising at least two functional groups, II) providing another water solution containing phosphate ions and water-soluble organic compound(s) comprising at least two functional groups, followed by III) mixing the solutions of (I) and (II) to create calcium phosphate particles coated with said water-soluble organic compounds. After washing and drying, the coated particles may be used as scaffolds or for production of a powder of calcium phosphate particles or crystals.Type: GrantFiled: November 26, 2008Date of Patent: May 22, 2018Assignee: Promimic ABInventor: Per Kjellin -
Patent number: 9782435Abstract: Composites and methods of producing a mouldable bone substitute are described. A scaffold for bone growth comprises nanocrystalline hydroxyapatite (HA), a bioresorbable plasticizer, and a biodegradable polymer. Plasticizers of the invention include oleic acid, tocopherol, eugenol, 1,2,3-triacetoxypropane, monoolein, and octyl-beta-D-glucopyranoside. Polymers of the invention include poly(caprolactone), poly(D,L-Lactic acid), and poly(glycolide-co lactide). Methods of regulating porosity, hardening speed, and shapeability are also described. Composites and methods are described using nanocrystalline HA produced with and without amino acids. The scaffold for bone growth described herein displays increased strength and shapeability.Type: GrantFiled: June 12, 2015Date of Patent: October 10, 2017Assignee: Promimic ABInventors: Per Kjellin, Paul Handa
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Publication number: 20150352258Abstract: Composites and methods of producing a mouldable bone substitute are described. A scaffold for bone growth comprises nanocrystalline hydroxyapatite (HA), a bioresorbable plasticizer, and a biodegradable polymer. Plasticizers of the invention include oleic acid, tocopherol, eugenol, 1,2,3-triacetoxypropane, monoolein, and octyl-beta-D-glucopyranoside. Polymers of the invention include poly(caprolactone), poly(D,L-Lactic acid), and poly(glycolide-co lactide). Methods of regulating porosity, hardening speed, and shapeability are also described. Composites and methods are described using nanocrystalline HA produced with and without amino acids. The scaffold for bone growth described herein displays increased strength and shapeability.Type: ApplicationFiled: June 12, 2015Publication date: December 10, 2015Inventors: Per Kjellin, Paul Handa
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Patent number: 9066935Abstract: Composites and methods of producing a moldable bone substitute are described. A scaffold for bone growth comprises nanocrystalline hydroxyapatite (HA), a bioresorbable plasticizer, and a biodegradable polymer. Plasticizers of the invention include oleic acid, tocopherol, eugenol, 1,2,3-triacetoxypropane, monoolein, and octyl-beta-D-glucopyranoside. Polymers of the invention include poly(caprolactone), poly(D,L-Lactic acid), and poly(glycolide-co lactide). Methods of regulating porosity, hardening speed, and shapeability are also described. Composites and methods are described using nanocrystalline HA produced with and without amino acids. The scaffold for bone growth described herein displays increased strength and shapeability.Type: GrantFiled: July 8, 2013Date of Patent: June 30, 2015Assignee: Promimic ABInventors: Per Kjellin, Paul Handa
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Patent number: 8632843Abstract: The invention provides methods and systems that control the application of a material onto micro-rough implant surfaces. Thus, the present invention provides method of applying crystalline nanoparticles onto the surface of an implant to produce an implant with a crystalline nanoparticle layer on its surface, the method comprising: providing an implant substrate body; applying crystalline nanoparticles onto the surface of the implant; and rotating the implant, to produce an implant with a crystalline nanoparticle layer on its surface. This method of nanoparticle application is designed to promote the integration of implants, such as dental and orthopedic screws, into living tissue, and offers the ability to control the thickness and uniformity of the nanoparticle layer, in one or several layers, while simultaneously retaining the microroughness of the implant.Type: GrantFiled: November 24, 2008Date of Patent: January 21, 2014Assignee: Promimic ABInventors: Martin Andersson, Fredrik Currie, Per Kjellin
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Publication number: 20130295194Abstract: Composites and methods of producing a mouldable bone substitute are described, A scaffold for bone growth comprises nanocrystalline hydroxyapatite (HA), a bioresorbable plasticizer, and a biodegradable polymer. Plasticizers of the invention include oleic acid, tocopherol, eugenol, 1,2,3-triacetoxypropane, monoolein, and octyl-beta-D-glucopyranoside. Polymers of the invention include poly(caprolactone), poly(D,L-Lactic acid), and poly(glycolide-co lactide). Methods of regulating porosity, hardening speed, and shapeability are also described. Composites and methods are described using nanocrystalline HA produced with and without amino acids. The scaffold for bone growth described herein displays increased strength and shapeability.Type: ApplicationFiled: July 8, 2013Publication date: November 7, 2013Inventors: Per Kjellin, Paul Handa
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Publication number: 20130251982Abstract: Synthetic nano-sized crystalline calcium phosphate, particularly hydroxyapatite, having a specific surface area in the range of 150 m2/g to 300 m2/g, is described. The nano-sized crystalline calcium phosphate may be in the form of a powder or in the form of a coating on a surface. A method of producing a nano-sized crystalline calcium phosphate powder or coating is also described.Type: ApplicationFiled: May 13, 2013Publication date: September 26, 2013Inventors: Per Kjellin, Martin Andersson
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Patent number: 8460788Abstract: Synthetic nano-sized crystalline calcium phosphate, particularly hydroxyapatite, having a specific surface area in the range of 150 m2/g to 300 m2/g, is described. The nano-sized crystalline calcium phosphate may be in the form of a powder or in the form of a coating on a surface. A method of producing a nano-sized crystalline calcium phosphate powder or coating is also described.Type: GrantFiled: May 30, 2012Date of Patent: June 11, 2013Assignee: Promimic ABInventors: Per Kjellin, Martin Andersson
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Publication number: 20120282457Abstract: Synthetic nano-sized crystalline calcium phosphate, particularly hydroxyapatite, having a specific surface area in the range of 150 m2/g to 300 m2/g, is described. The nano-sized crystalline calcium phosphate may be in the form of a powder or in the form of a coating on a surface. A method of producing a nano-sized crystalline calcium phosphate powder or coating is also described.Type: ApplicationFiled: May 30, 2012Publication date: November 8, 2012Inventors: Per Kjellin, Martin Andersson
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Patent number: 8206813Abstract: Synthetic nano-sized crystalline calcium phosphate, particularly hydroxyapatite, having a specific surface area in the range of 150 m2/g to 300 m2/g, is described. The nano-sized crystalline calcium phosphate may be in the form of a powder or in the form of a coating on a surface. A method of producing a nano-sized crystalline calcium phosphate powder or coating is also described.Type: GrantFiled: June 14, 2005Date of Patent: June 26, 2012Assignee: Promimic ABInventors: Per Kjellin, Martin Andersson
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Patent number: 8093005Abstract: A method of preparing a protein-resistant reactive solid support surface is disclosed. The method comprises the steps of providing a solid support having a hydrogel coating with a plurality of binding elements, coupling a protein resistant compound to the hydrogel via a first fraction of the binding elements, and coupling at least one binding agent to the hydrogel via a second fraction of the binding elements, whereby the protein resistant compound and the at least one binding agent are co-immobilized to the hydrogel. Also the use of the reactive surface in analysis, such as immunogenicity assays, is disclosed.Type: GrantFiled: October 19, 2009Date of Patent: January 10, 2012Assignee: GE Healthcare Bio-Sciences ABInventors: Tanja Jarhede, Per Kjellin, Anita Larsson, Hans Sjobom
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PRODUCTION OF NANOSIZED CALCIUM PHOSPHATE PARTICLES AS POWDER OR COATING VIA BIFUNCTIONAL PRECURSORS
Publication number: 20110282095Abstract: Method of producing calcium phosphate particles, such as hydroxyapatite particles, in the form of a powder or coating on a solid support comprising an oxide surface or a polymer surface, such as titanium, titanium alloys, stainless steel, zirconia, glass and poly(styrene), poly(ether ether ketone) (PEEK), and poly(imide) is described. The method comprises I) providing a water solution containing calcium ions and water-soluble organic compound(s) comprising at least two functional groups, II) providing another water solution containing phosphate ions and water-soluble organic compound(s) comprising at least two functional groups, followed by III) mixing the solutions of (I) and (II) to create calcium phosphate particles coated with said water-soluble organic compounds. After washing and drying, the coated particles may be used as scaffolds or for production of a powder of calcium phosphate particles or crystals.Type: ApplicationFiled: November 26, 2008Publication date: November 17, 2011Applicant: Promimic ABInventor: Per Kjellin -
Publication number: 20100226956Abstract: Composites and methods of producing a mouldable bone substitute are described. A scaffold for bone growth comprises nanocrystalline hydroxyapatite (HA), a bioresorbable plasticizer, and a biodegradable polymer. Plasticizers of the invention include oleic acid, tocopherol, eugenol, 1,2,3-triacetoxypropane, monoolein, and octyl-beta-D-glucopyranoside. Polymers of the invention include poly(caprolactone), poly(D,L-Lactic acid), and poly(glycolide-co lactide). Methods of regulating porosity, hardening speed, and shapeability are also described. Composites and methods are described using nanocrystalline HA produced with and without amino acids. The scaffold for bone growth described herein displays increased strength and shapeability.Type: ApplicationFiled: March 5, 2010Publication date: September 9, 2010Inventors: Per Kjellin, Paul Handa
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Publication number: 20100131062Abstract: The invention provides methods and systems that control the application of a material onto micro-rough implant surfaces. Thus, the present invention provides method of applying crystalline nanoparticles onto the surface of an implant to produce an implant with a crystalline nanoparticle layer on its surface, the method comprising: providing an implant substrate body; applying crystalline nanoparticles onto the surface of the implant; and rotating the implant, to produce an implant with a crystalline nanoparticle layer on its surface. This method of nanoparticle application is designed to promote the integration of implants, such as dental and orthopedic screws, into living tissue, and offers the ability to control the thickness and uniformity of the nanoparticle layer, in one or several layers, while simultaneously retaining the microroughness of the implant.Type: ApplicationFiled: November 24, 2008Publication date: May 27, 2010Inventors: Martin Andersson, Fredrik Currie, Per Kjellin
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Publication number: 20100041127Abstract: A method of preparing a protein-resistant reactive solid support surface is disclosed. The method comprises the steps of providing a solid support having a hydrogel coating with a plurality of binding elements, coupling a protein resistant compound to the hydrogel via a first fraction of the binding elements, and coupling at least one binding agent to the hydrogel via a second fraction of the binding elements, whereby the protein resistant compound and the at least one binding agent are co-immobilized to the hydrogel. Also the use of the reactive surface in analysis, such as immunogenicity assays, is disclosed.Type: ApplicationFiled: October 19, 2009Publication date: February 18, 2010Applicant: GE HEAL THCARE BIO-SCIENCES ABInventors: TANJA JARHEDE, Per Kjellin, Anita Larsson, Hans Sjöbom