Abstract: The present invention relates to methods for loading extracellular vesicles (EVs) with a pharmacological agent. The invention discloses the use of cell-penetrating peptides as carriers into EVs, using either a non-covalent or covalent loading approach. Furthermore, the present invention pertains to medical uses and compositions comprising such pharmacological agent-loaded EVs.

Abstract: The present invention relates to methods for loading extracellular vesicles (EVs) with a pharmacological agent. The invention discloses the use of cell-penetrating peptides as carriers into EVs, using either a non-covalent or covalent loading approach. Furthermore, the present invention pertains to medical uses and compositions comprising such pharmacological agent-loaded EVs.

Abstract: The present invention relates to administration of gene therapy, in particular the development of effective combinatorial strategies for gene delivery in inter alia monogenetic diseases. More specifically, the present invention relates to a combination therapy, methods of producing the combination therapy, as well as various related embodiments.

Abstract: The present invention pertains to affinity-based isolation and purification of drug-loaded extracellular vesicles, notably exosomes, wherein the exosomes are engineered to enable affinity purification.

Abstract: The present invention relates to extracellular vesicle (EV)-mediated delivery of protein-based therapeutics. More specifically, the invention relates to delivery of complex polypeptide-based agents which typically bind to target proteins extracellularly, intracellularly, or in the cell membrane.

Abstract: The present invention relates to extracellular vesicles (EVs) as a novel therapeutic approach to lysosomal storage disorders (LSD). More specifically, the invention relates to the use of various protein engineering strategies for improving loading of hard-to-load LSD-related proteins and targeting of the resultant EVs to tissues and organs of interest.

Abstract: The present invention relates to methods for loading extracellular vesicles (EVs) with a pharmacological agent. The invention discloses the use of cell-penetrating peptides as carriers into EVs, using either a non-covalent or covalent loading approach. Furthermore, the present invention pertains to medical uses and compositions comprising such pharmacological agent-loaded EVs.

Abstract: The present invention relates to a system for intracellular delivery of a cargo comprising at least one component A chosen from aliphatic linear or branched moieties with at least 4 carbon atoms and/or cyclic ring systems comprising 2-4 rings which may contain several hetero atoms chosen from N, S, O and P, wherein component(s) A is (are) attached to a cell penetrating peptide B and/or a non-peptide analogue thereof. It also relates to methods of using the system in diagnosis of diseases, as research tool and as a targeting system, a composition comprising the system and especially a pharmaceutical composition a material covered with the system and a material having the delivery systems into the material. Finally it relates to novel peptides.

Abstract: A cash deposit apparatus has a user interface module that provides a user interface at a first external side of the apparatus and allows a user to interact with a cash processing transaction of the apparatus. A cash processing module processes cash deposited by the user and determines a value related to the processed cash, and has a service interface for providing access to the cash processing module. A cash storage module stores cash as processed by the cash processing module and has a cash storage interface for providing access to the cash storage module. The cash processing module and the cash storage module are independently configurable.

Abstract: The present invention relates to a system for intracellular delivery of a cargo comprising at least one component A chosen from aliphatic linear or branched moieties with at least 4 carbon atoms and/or cyclic ring systems comprising 2-4 rings which may contain several hetero atoms chosen from N, S, O and P, wherein component(s) A is (are) attached to a cell penetrating peptide B and/or a non-peptide analogue thereof. It also relates to methods of using the system in diagnosis of diseases, as research tool and as a targeting system, a composition comprising the system and especially a pharmaceutical composition a material covered with the system and a material having the delivery systems into the material. Finally it relates to novel peptides.

Abstract: A cash deposit apparatus has a user interface module that provides a user interface at a first external side of the apparatus and allows a user to interact with a cash processing transaction of the apparatus. A cash processing module processes cash deposited by the user and determines a value related to the processed cash, and has a service interface for providing access to the cash processing module. A cash storage module stores cash as processed by the cash processing module and has a cash storage interface for providing access to the cash storage module. The cash processing module and the cash storage module are independently configurable.

Abstract: System for use of a microprocessor for drawing of winners in a lottery with an in advance given dividend, at which each lottery ticket includes at least one counter of bingo type with a number in rows and columns provided numbers as well as for the lottery ticket unique identification. The identification of each lottery ticket and number row of a counter are stored in a first register which is readable by a microprocessor, that a number of number sequences are created and stored in a second register which is readable by a microprocessor, in such a way that each of the number sequences is unique and gives a number of prize-winning rows of numbers among the counters, which number corresponds to the given dividend. One of the number sequences in the second register is selected by a random draw. The microprocessor compares this chosen number sequence with the number rows in the first register and shows the identification that indicates counters with a prize-winning row of numbers.