Patents by Inventor Per Mansson
Per Mansson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8834798Abstract: There is provided an analysis device comprising a gas phase and a liquid phase and at least one sensor, said sensor having at least one point where an analyte is detected, said at least point being in contact with the liquid phase, characterized in that the device comprises a membrane with a first and a second side, which membrane is in contact with the gas phase on at least a part of one side of the membrane and which membrane is in contact with the liquid phase on at least a part of the other side of the membrane, wherein the membrane comprises openings, and wherein the largest possible distance between any two openings in the membrane is larger than the distance between the membrane and the point where an analyte is detected, moreover there is provided a method for analyzing an analyte in a gas phase.Type: GrantFiled: January 18, 2008Date of Patent: September 16, 2014Assignee: Aerocrine ABInventors: Thomas Frisk, Wouter Van Der Wijngaart, Göran Stemme, Per Månsson
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Publication number: 20120040473Abstract: A method of individually analyzing with a surface acoustic wave (SAW) sensor apparatus the presence or absence of at least two different target antigens in a liquid sample is described. The method comprises providing and running a single flow cell comprising a SAW sensor chip with at least two, e.g. twelve, SAW sensor elements, each comprising an individual coating immobilizing and exposing a modified antigen that has a weaker affinity for an antibody which is specific for one of the target antigens than the target antigen itself. Such a flow cell and surface acoustic wave (SAW) sensor chip for immunological displacement reactions are also disclosed.Type: ApplicationFiled: January 30, 2009Publication date: February 16, 2012Applicant: Biosensor Applications Sweden ABInventor: Per Mansson
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Patent number: 7863056Abstract: A coated metal surface on a solid support, wherein the coating consists of a protein layer firmly attached to the metal surface, and said protein layer is coupled to linker molecules that are bound to low molecular weight antigens, wherein the linker molecules are coupled to the protein layer and are bound to the antigen via functional end groups and contain between the functional end groups an aliphatic hydrocarbon of 1, 2 or 3 carbon atoms, and wherein the antigens are optionally reversibly bound to antibodies specific for the antigens, is described. The coated metal surface on a solid support may be used in a method of detecting analyte antigens as part of an analysis device, such as a Piezoelectric Crystal Microbalance device or a Surface Plasmon Resonance biosensor, for detection in an aqueous solution of an analyte antigen with higher affinity to an antibody than the antigen of the coating by monitoring the displacement of the antibody from the coating.Type: GrantFiled: June 18, 2003Date of Patent: January 4, 2011Assignee: Biosensor Applications Sweden ABInventors: Per Månsson, Ann-Sofie Johansson, Björn Sandén, Shahin Loniakan
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Patent number: 7771657Abstract: A system, device and method for detection of several individual analytes in a test solution aliquot (83) with an array of individually operated piezoelectric crystal microbalances are described. The system comprises a connecting station (100) that receives a plurality of individually specific piezoelectric crystal microbalance flow-trough cells (10), each containing a piezoelectric crystal (50) carrying electrodes (56,62) and a coating (66,46) exposing a first member of an interaction pair specific for an individual analyte being a second member of the interaction pair. Flowing means (70) flows a solution (75) and the test solution aliquot (83) to and through a cell compartment of each of the cells (10) via the connecting station (100). Power and measurement means (130) oscillate the piezoelectric crystal(s) (50). A change in oscillating characteristics of the crystal(s) (50), following interaction between the first and second members of the interaction pair, detects presence of the individual analyte(s).Type: GrantFiled: June 18, 2003Date of Patent: August 10, 2010Assignee: Biosensor Applications Sweden ABInventors: Per Månsson, Henrik Andersson, Jan Smith, Kjeld Jensen, Teodor Aastrup
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Publication number: 20100144059Abstract: There is provided an analysis device comprising a gas phase and a liquid phase and at least one sensor, said sensor having at least one point where an analyte is detected, said at least point being in contact with the liquid phase, characterised in that the device comprises a membrane with a first and a second side, which membrane is in contact with the gas phase on at least a part of one side of the membrane and which membrane is in contact with the liquid phase on at least a part of the other side of the membrane, wherein the membrane comprises openings, and wherein the largest possible distance between any two openings in the membrane is larger than the distance between the membrane and the point where an analyte is detected, moreover there is provided a method for analysing an analyte in a gas phase.Type: ApplicationFiled: January 18, 2008Publication date: June 10, 2010Applicant: Aerocrine ABInventors: Thomas Frisk, Wouter Van Der Wijngaart, Göran Stemme, Per Månsson
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Publication number: 20100112720Abstract: A continuously repeatable method of detecting possible presence of one or several different selected target antigen(s), such as explosives and/or narcotics, in a predetermined test volume with a flow-through analysis device, such as a Piezoelectric Quartz Crystal Microbalance device (QCM), an Ellipsometer device or a Surface Plasmon Resonance biosensor device, is described. The device is equipped with one or several fluidly connected, individually operated, flow-through testing cells, each cell containing a sensing surface, each sensing surface comprising a selected modified target antigen immobilized thereon, which modified antigen has weaker affinity than the target antigen for a selected antibody specific for the selected target antigen. One testing cell is for analyzing a target antigen by the competition mode, whereas optional other testing cells are individually selected for analysis by the competition mode or the displacement mode.Type: ApplicationFiled: December 10, 2007Publication date: May 6, 2010Applicant: Biosensor Applications Sweden ABInventors: Per Mansson, Bjorn Sanden
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Publication number: 20090168068Abstract: A coated metal surface on a solid support, wherein the coating consists of a self-assembled monolayer (SAM) of oligo(ethylene glycol)-terminated amide group-containing alkyl thiols firmly attached to the metal surface via the thiol-end and low molecular weight antigens bound via an amide-group to the SAM-forming OEG molecule, wherein the alkyl portion has 1-20 methylene groups, wherein the oligo(ethylene glycol) portion has 1-15 ethylene oxy units, and wherein the antigens, such as explosives and narcotics, are optionally reversibly bound to antibodies specific for the antigens, is disclosed. The coated metal surface on a solid support may be used in a method of detecting analyte antigens as part of an analysis device, such as a Piezoelectric Crystal Microbalance device or a Surface Plasmon Resonance biosensor, for detection in an aqueous solution of an analyte antigen with higher affinity to an antibody than the antigen of the coating by monitoring the displacement of the antibody from the coating.Type: ApplicationFiled: October 23, 2008Publication date: July 2, 2009Applicant: BIOSENSOR APPLICATION SWEDEN ABInventors: Per Mansson, Bo Liedberg
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Publication number: 20080050795Abstract: A mixture of isolated or synthetic affinity molecules in a liquid carrier is disclosed. The mixture comprises at least two different affinity molecules, each with affinity for a predetermined analyte, for use in a single or multi flow cell piezoelectric crystal micro balance apparatus. Each isolated or synthetic affinity molecule forms together with the predetermined analyte an interaction pair selected from the group consisting of anion-cation, antibody-antigen, receptor-ligand, enzyme-substrate, oligonucleotide-oligonucleotide with complementary sequence, oligonucleotide-protein, oligonucleotide-cell, and peptide nucleic acid (PNA) oligomer-polynucleotide, wherein the polynucleotide may be selected from the group consisting of RNA, DNA and PNA polymers complementary to PNA oligomer. Use of the mixture for introduction into the liquid flow of a single or multi flow cell piezoelectric crystal micro balance apparatus is also described, as well as a kit containing the mixture.Type: ApplicationFiled: November 19, 2004Publication date: February 28, 2008Applicant: Biosensor Applications Sweden ABInventors: Per Mansson, Daniel Berggren, Carl Lundberg, Ann-Charlotte Hellgren, Lena Hojvall
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Publication number: 20070163327Abstract: A system and a method for detection of trace amounts of airborne or deposited low-molecular weight compound(s), such as narcotics or explosives, comprising an electrically charged collector surface connected to an ionizer ionizing airborne particles with an electrical charge opposite to the charge of the collector surface, optional air-stirring means, extraction means for extraction of collected material from the collector surface, and equipment for chemical and/or biochemical detection of said compound(s) from said extracted collected material, is disclosed. Further, a modified ionizer/collector device wherein the collector is extended from the body of the device and is equipped with a preferably detachable, electrically chargeable collecting surface and wherein optionally the air-ionizing part of the device is also extended from the body of the ionizer/collector device, either together with or apart from, the extended collector arm, is described.Type: ApplicationFiled: May 18, 2004Publication date: July 19, 2007Applicant: Biosensor Applications Swedeen AB (publInventor: Per Mansson
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Patent number: 7089812Abstract: An apparatus (10) and a method for concentrating and transferring volatile compounds contained in a sample on a detachable solid support (12) into a liquid for subsequent detection and/or analysis of the volatile compounds, are described. The apparatus comprises a holder (14) for the solid support (12), means (16) for transporting the holder (14) to a heating position on a heatable plate (18), an enclosed space-creating arrangement comprising the heatable plate (18) attached to a movable housing (30), the holder (14), the solid support (12), a funnel (20) on the solid support (12), and inside the funnel (20) a chilled member (22), means inside the housing (30) for heating the heatable plate (18) to evaporate the volatile compounds which then are condensed on the chilled member (22), means (24) for transporting the chilled member (22) from a cooler (26) to the inside of the funnel (20) and from there to a position (28) where condensed compounds are removed from the chilled member (22) into a liquid.Type: GrantFiled: November 19, 2002Date of Patent: August 15, 2006Assignee: Biosensor Applications Sweden ABInventors: Per Månsson, Jan Smith, Ann-Charlotte Hellgren
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Publication number: 20060105471Abstract: A coated metal surface on a solid support, wherein the coating consists of a protein layer firmly attached to the metal surface, and said protein layer is coupled to linker molecules that are bound to low molecular weight antigens, wherein the linker molecules are coupled to the protein layer and are bound to the antigen via functional end groups and contain between the functional end groups an aliphatic hydrocarbon of 1, 2 or 3 carbon atoms, and wherein the antigens are optionally reversibly bound to antibodies specific for the antigens, is described. The coated metal surface on a solid support may be used in a method of detecting analyte antigens as part of an analysis device, such as a Piezoelectric Crystal Microbalance device or a Surface Plasmon Resonance biosensor, for detection in an aqueous solution of an analyte antigen with higher affinity to an antibody than the antigen of the coating by monitoring the displacement of the antibody from the coating.Type: ApplicationFiled: June 18, 2003Publication date: May 18, 2006Applicant: BIOSENOR APPLICATIONS SWEDEN ABInventors: Per Mansson, Ann-Sofie Johansson, Bjorn Sanden, Shahin Loniakan
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Publication number: 20060057635Abstract: A coated metal surface on a solid support, wherein the coating consists of a self-assembled monolayer (SAM) of oligo(ethylene glycol)-terminated amide group-containing alkyl thiols firmly attached to the metal surface via the thiol-end and low molecular weight antigens bound via an amide-group to the SAM-forming OEG molecule, wherein the alkyl portion has 1-20 methylene groups, wherein the oligo(ethylene glycol) portion has 1-15 ethylene oxy units, and wherein the antigens, such as explosives and narcotics, are optionally reversibly bound to antibodies specific for the antigens, is disclosed. The coated metal surface on a solid support may be used in a method of detecting analyte antigens as part of an analysis device, such as a Piezoelectric Crystal Microbalance device or a Surface Plasmon Resonance biosensor, for detection in an aqueous solution of an analyte antigen with higher affinity to an antibody than the antigen of the coating by monitoring the displacement of the antibody from the coating.Type: ApplicationFiled: June 18, 2003Publication date: March 16, 2006Inventors: Per Mansson, Bo Liedberg
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Publication number: 20060014270Abstract: A system, device and method for detection of several individual analytes in a test solution aliquot (83) with an array of individually operated piezoelectric crystal microbalances are described. The system comprises a connecting station (100) that receives a plurality of individually specific piezoelectric crystal microbalance flow-trough cells (10), each containing a piezoelectric crystal (50) carrying electrodes (56,62) and a coating (66,46) exposing a first member of an interaction pair specific for an individual analyte being a second member of the interaction pair. Flowing means (70) flows a solution (75) and the test solution aliquot (83) to and through a cell compartment of each of the cells (10) via the connecting station (100). Power and measurement means (130) oscillate the piezoelectric crystal(s) (50). A change in oscillating characteristics of the crystal(s) (50), following interaction between the first and second members of the interaction pair, detects presence of the individual analyte(s).Type: ApplicationFiled: June 18, 2003Publication date: January 19, 2006Applicant: BIOSENSOR APPLICATIONS SWEDEN ABInventors: Per Mansson, Henrik Andersson, Jan Smith, Kjeld Jensen, Teodor Aastrup
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Publication number: 20050016300Abstract: An apparatus (10) and a method for concentrating and transferring volatile compounds contained in a sample on a detachable solid support (12) into a liquid for subsequent detection and/or analysis of the volatile compounds, are described. The apparatus comprises a holder (14) for the solid support (12), means (16) for transporting the holder (14) to a heating position on a heatable plate (18), a closed room-creating arrangement comprising the heatable plate (18) attached to a movable housing (30), the holder (14), the solid support (12), a funnel (20) on the solid support (12), and inside the funnel (20) a cold spot (22), means inside the housing (30) for heating the heatable plate (18) to evaporate the volatile compounds which then are condensed on the cold spot (22), means (24) for transporting the cold spot (22) from a cooler (26) to the inside of the funnel (20) and from there to a position (28) where condensed compounds are removed from the cold spot (22) into a liquid.Type: ApplicationFiled: November 19, 2002Publication date: January 27, 2005Inventors: Per Mansson, Jan Smith, Ann-Charlotte Hellgren
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Patent number: 6706499Abstract: A medium is disclosed for embedding and preserving single cells or a cell tissue for an extended period of time at a temperature not exceeding 0° C. in a state suitable for DNA and/or RNA amplification, comprising an aqueous solution of at least one water-soluble cellulose derivative and, optionally, an osmotic pressure stabilizing agent. A method for preserving single cells or a cell tissue for an extended period of time at a temperature not exceeding 0° C. in a state suitable for DNA and/or RNA amplification using the above medium is also disclosed.Type: GrantFiled: November 13, 2001Date of Patent: March 16, 2004Assignee: Ascendia ABInventors: Per Månsson, Tomas Lundin
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Patent number: 6479283Abstract: A method for stimulating pancreatic cells to synthesize and/or excrete insulin comprises contacting insulin-producing cells, in particular their aqueous suspension, with a water-soluble cellulose derivative, in particular selected from alkylated, hydroxyalkylated, and alkylated-hydroxyalkylated cellulose or a mixture thereof. A medium for the culture of pancreatic &bgr;-cells contains an effective cell-stimulating amount of a cellulose derivative. It can be used to stimulate pancreatic &bgr;-cells to produce and/or excrete insulin. An apparatus for such stimulation comprises a container holding a solution of a cellulose derivative in an aqueous culture medium. Stimulation of pancreatic &bgr;-cells by a cellulose derivative is useful in the management of diabetes. Further preservative or therapeutic methods using the aqueous cellulose derivatives are disclosed.Type: GrantFiled: December 17, 1999Date of Patent: November 12, 2002Assignee: Ascendia ABInventors: Per Månsson, Tomas Lundin, Christer Busch
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Publication number: 20020150928Abstract: A medium is disclosed for embedding and preserving single cells or a cell tissue for an extended period of time at a temperature not exceeding 0° C. in a state suitable for DNA and/or RNA amplification, comprising an aqueous solution of at least one water-soluble cellulose derivative and, optionally, an osmotic pressure stabilizing agent. A method for preserving single cells or a cell tissue for an extended period of time at a temperature not exceeding 0° C. in a state suitable for DNA and/or RNA amplification using the above medium is also disclosed.Type: ApplicationFiled: November 13, 2001Publication date: October 17, 2002Applicant: Ascendia ABInventors: Per Mansson, Tomas Lundin
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Patent number: 5429838Abstract: In a method for producing intraocular lenses with improved optical properties, applying to the optical part of the lens a coating to protect the surface during one or more processing steps which are carried out under conditions so that the protective coating is essentially insoluble and remains adhered to the lens, and removing the coating by changing the conditions which make the coating adhere to the lens.Type: GrantFiled: October 5, 1993Date of Patent: July 4, 1995Assignee: Pharmacia ABInventors: Per Mansson, Johannes Hermans
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Patent number: 5375611Abstract: Method for extracapsular cataract extraction with or without posterior chamber intraocular lens implantation comprising chemical modification of the posterior surface of the lens capsule, at least in the optical portion of said capsule, for preventing cell attachment and growth.Type: GrantFiled: January 26, 1993Date of Patent: December 27, 1994Assignee: Pharmacia ABInventors: Bengt Lindqvist, Per Mansson, Tomas Malson
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Patent number: D489319Type: GrantFiled: August 23, 2002Date of Patent: May 4, 2004Assignee: Biosensor Applications Sweden ABInventors: Per Månsson, Kjeld Jensen, Teodor Aastrup, Henrik Andersson, Jan Smith