Patents by Inventor Per-Olof Berggren

Per-Olof Berggren has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods and reagents for treating diabetes
    Patent number: 11707490
    Abstract: Disclosed are methods for treating or limiting development of diabetes, by transplanting into the eye of a subject with diabetes or at risk of diabetes an amount effective to treat or limit development of diabetes of insulin-producing cells engineered to reduce expression of a ?3 subunit of Cav (Cav?3).
    Type: Grant
    Filed: July 16, 2019
    Date of Patent: July 25, 2023
    Inventor: Per Olof Berggren
  • Methods and reagents for treating diabetes
    Publication number: 20230111951
    Abstract: Disclosed are methods for treating or limiting development of diabetes, by transplanting into the eye of a subject with diabetes or at risk of diabetes an amount effective to treat or limit development of diabetes of insulin-producing cells engineered to reduce expression of a ?3 subunit of Cav (Cav?3).
    Type: Application
    Filed: December 8, 2022
    Publication date: April 13, 2023
    Inventor: Per-Olof Berggren
  • Methods for monitoring physiological status of a body organ
    Publication number: 20230079688
    Abstract: The present invention provides method for monitoring physiological status of an organ in a subject by monitoring morphological changes over time in transplanted tissue on an eye of the subject.
    Type: Application
    Filed: November 22, 2022
    Publication date: March 16, 2023
    Inventor: Per-Olof Berggren
  • Methods for monitoring physiological status of a body organ
    Patent number: 11519902
    Abstract: The present invention provides method for monitoring physiological status of an organ in a subject by monitoring morphological changes over time in transplanted tissue on an eye of the subject.
    Type: Grant
    Filed: May 30, 2019
    Date of Patent: December 6, 2022
    Assignee: Biocrine AB
    Inventor: Per-Olof Berggren
  • ApoCIII and the Treatment and Diagnosis of Diabetes
    Publication number: 20200300875
    Abstract: The present invention provides methods of identifying candidate compounds for the treatment of type I diabetes comprising contacting pancreatic ? cells with an amount of apolipoprotein CIII (“apoCIII”) effective to increase intracellular calcium concentration, in the presence of one or more test compounds, and identifying those test compounds that inhibit an apoCIII-induced increase in intracellular calcium concentration in the pancreatic ? cells. The present invention also provides methods for treating patients with type I diabetes comprising administering to the patient an amount effective of an inhibitor of apoCIII to reduce apoCIII-induced increase in intracellular calcium concentration in pancreatic ? cells.
    Type: Application
    Filed: June 11, 2020
    Publication date: September 24, 2020
    Inventor: Per-Olof BERGGREN
  • Methods for treating and/or limiting development of diabetes in subjects with amyotrophic lateral sclerosis
    Patent number: 10695425
    Abstract: Methods for treating and/or limiting development of diabetes in a subject with amyotrophic lateral sclerosis (ALS) by inhibiting IgG-mediated activation of voltage-gated calcium channels (VGCCs) in cells of the subject, by one or more of removing IgG from blood of the subject, blocking IgG from activating VGCCs in the subject; or blocking VGCCs in the subject are described, as are methods for identifying ALS patients at risk of developing diabetes.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: June 30, 2020
    Assignee: Biocrine AB
    Inventor: Per-Olof Berggren
  • Non-invasive in vivo imaging and methods for treating type I diabetes
    Publication number: 20200061121
    Abstract: The present invention provides novel drug discovery platforms and methods for treating diabetes.
    Type: Application
    Filed: October 31, 2019
    Publication date: February 27, 2020
    Inventors: Per-Olof Berggren, Alejandro Caicedo
  • Methods and Reagents for Treating Diabetes
    Publication number: 20200023013
    Abstract: Disclosed are methods for treating or limiting development of diabetes, by transplanting into the eye of a subject with diabetes or at risk of diabetes an amount effective to treat or limit development of diabetes of insulin-producing cells engineered to reduce expression of a ?3 subunit of Cav (Cav?3).
    Type: Application
    Filed: July 16, 2019
    Publication date: January 23, 2020
    Inventor: Per Olof BERGGREN
  • Non-invasive in vivo imaging and methods for treating diabetes
    Patent number: 10493108
    Abstract: The present invention provides novel drug discovery platforms and methods for treating diabetes.
    Type: Grant
    Filed: November 6, 2018
    Date of Patent: December 3, 2019
    Assignee: BioCrine AB
    Inventors: Per-Olof Berggren, Alejandro Caicedo
  • Methods for monitoring physiological status of a body organ
    Publication number: 20190317076
    Abstract: The present invention provides method for monitoring physiological status of an organ in a subject by monitoring morphological changes over time in transplanted tissue on an eye of the subject.
    Type: Application
    Filed: May 30, 2019
    Publication date: October 17, 2019
    Inventor: Per-Olof Berggren
  • Methods for monitoring physiological status of a body organ
    Patent number: 10338060
    Abstract: The present invention provides method for monitoring physiological status of an organ in a subject by monitoring morphological changes over time in transplanted tissue on an eye of the subject.
    Type: Grant
    Filed: November 5, 2018
    Date of Patent: July 2, 2019
    Assignee: BioCrine AB
    Inventor: Per-Olof Berggren
  • Method of highly expressing target protein from plant using RbcS fusion protein and method of preparing composition for oral administration of medical protein using target protein expression plant body
    Patent number: 10239928
    Abstract: The present invention provides a plant expressing a target protein, a method of preparing the same and a method of preparing a composition for oral administration of a biopharmaceutical using the same. A target protein expression system using plant cells according to the present invention solves conventional problems in plant cell culture, provides a method of producing a large quantity of target proteins including a biopharmaceutical protein and allowing a target protein to have a resistance to a protease present in a digestive organ, and therefore is very effective to enable commercialization of plant-derived biopharmaceuticals.
    Type: Grant
    Filed: May 17, 2017
    Date of Patent: March 26, 2019
    Assignee: POSTECH ACADEMY-INDUSTRY FOUNDATION
    Inventors: Inhwan Hwang, Hyang Ju Kang, Eun Ju Sohn, Yong Jik Lee, Per-Olof Berggren, Yun Joo Yoo, Jae Yoon Kim
  • Methods for monitoring physiological status of a body organ
    Patent number: 10228364
    Abstract: The present invention provides method for monitoring physiological status of an organ in a subject by monitoring morphological changes over time in transplanted tissue on an eye of the subject.
    Type: Grant
    Filed: June 13, 2017
    Date of Patent: March 12, 2019
    Assignee: BioCrine AB
    Inventor: Per-Olof Berggren
  • Methods for treating and/or limiting development of diabetes
    Patent number: 10226530
    Abstract: The present invention provides methods for identifying candidate compounds for limiting development of and/or treating diabetes, and methods for limiting development of and/or treating diabetes.
    Type: Grant
    Filed: July 26, 2017
    Date of Patent: March 12, 2019
    Assignee: BioCrine AB
    Inventors: Per Olof Berggren, Shao-Nian Yang
  • Non-invasive in vivo imaging and methods for treating diabetes
    Publication number: 20190070316
    Abstract: The present invention provides novel drug discovery platforms and methods for treating diabetes.
    Type: Application
    Filed: November 6, 2018
    Publication date: March 7, 2019
    Inventors: Per-Olof Berggren, Alejandro Caicedo
  • Methods for monitoring physiological status of a body organ
    Publication number: 20190072542
    Abstract: The present invention provides method for monitoring physiological status of an organ in a subject by monitoring morphological changes over time in transplanted tissue on an eye of the subject.
    Type: Application
    Filed: November 5, 2018
    Publication date: March 7, 2019
    Inventor: Per-Olof Berggren
  • Non-invasive in vivo imaging and methods for treating type I diabetes
    Patent number: 10207012
    Abstract: The present invention provides novel drug discovery platforms and methods for treating type I diabetes.
    Type: Grant
    Filed: September 14, 2016
    Date of Patent: February 19, 2019
    Assignee: Biocrine AB
    Inventors: Per-Olof Berggren, Alejandro Caicedo
  • ApoCIII and the Treatment and Diagnosis of Diabetes
    Publication number: 20180348240
    Abstract: The present invention provides methods of identifying candidate compounds for the treatment of type I diabetes comprising contacting pancreatic ? cells with an amount of apolipoprotein CIII (“apoCIII”) effective to increase intracellular calcium concentration, in the presence of one or more test compounds, and identifying those test compounds that inhibit an apoCIII-induced increase in intracellular calcium concentration in the pancreatic ? cells. The present invention also provides methods for treating patients with type I diabetes comprising administering to the patient an amount effective of an inhibitor of apoCIII to reduce apoCIII-induced increase in intracellular calcium concentration in pancreatic ? cells.
    Type: Application
    Filed: July 31, 2018
    Publication date: December 6, 2018
    Inventor: Per-Olof BERGGREN
  • ApoIII and the treatment and diagnosis of diabetes
    Patent number: 10060935
    Abstract: The present invention provides methods of identifying candidate compounds for the treatment of type I diabetes comprising contacting pancreatic ? cells with an amount of apolipoprotein CIII (“apoCIII”) effective to increase intracellular calcium concentration, in the presence of one or more test compounds, and identifying those test compounds that inhibit an apoCIII-induced increase in intracellular calcium concentration in the pancreatic ? cells. The present invention also provides methods for treating patients with type I diabetes comprising administering to the patient an amount effective of an inhibitor of apoCIII to reduce apoCIII-induced increase in intracellular calcium concentration in pancreatic ? cells.
    Type: Grant
    Filed: January 18, 2017
    Date of Patent: August 28, 2018
    Assignee: BioCrine AB
    Inventor: Per-Olof Berggren
  • Methods for treating and/or limiting development of diabetes in subjects with amyotrophic lateral sclerosis
    Publication number: 20180236069
    Abstract: Methods for treating and/or limiting development of diabetes in a subject with amyotrophic lateral sclerosis (ALS) by inhibiting IgG-mediated activation of voltage-gated calcium channels (VGCCs) in cells of the subject, by one or more of removing IgG from blood of the subject, blocking IgG from activating VGCCs in the subject; or blocking VGCCs in the subject are described, as are methods for identifying ALS patients at risk of developing diabetes.
    Type: Application
    Filed: April 20, 2018
    Publication date: August 23, 2018
    Inventor: Per-Olof BERGGREN