Patents by Inventor Per Ove Öhman
Per Ove Öhman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190145966Abstract: Disclosed is an analytical device including at least one non-binding membrane; at least one liquid sample application region; and at least one capturing chamber including labelled particles; in which device the sample application region(s) are arranged upstream of the membrane while the capturing chamber(s) are arranged downstream of the membrane, and wherein the cut-off of the membrane is large enough to allow passage of labelled particles but small enough to retain clusters including analyte bound to particles. Also disclosed is a method of detecting one or more analytes such as biomarkers in a liquid sample such as blood using a device as disclosed.Type: ApplicationFiled: April 11, 2017Publication date: May 16, 2019Applicant: MEJE ABInventor: Per Ove ÖHMAN
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Patent number: 9606112Abstract: There is provided an assay device comprising a lid and a base, said base comprising, a sample addition zone, a reaction zone and an absorbing zone, said components being in fluid connection and being part of a fluid passage leading from the sample addition zone to the absorbing zone, wherein: (a) a sample addition well is integrated in the lid, (b) the absorbing zone consists of an area on an non-porous substrate, having substantially perpendicular projections, said projections defining a volume, which together with the volume of the fluid passage defines the sample volume subjected to the assay, and (c) at least one filter is between the sample addition well and the sample addition zone. There is further provided methods for handling samples.Type: GrantFiled: October 6, 2014Date of Patent: March 28, 2017Assignee: JOHNSON & JOHNSON ABInventors: Per Ove Öhman, Ib Mendel-Hartvig
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Publication number: 20160279590Abstract: A system is provided for dispensing a plurality of droplets substantially simultaneously onto a substrate (51). The liquids are stored in wells in a manifold plate (1) and transferred via micro capillaries to a transfer block (31). The transfer block comprises capillary through channels (33) which lead to outlets (41). The transfer block can be moved so that outlets can be brought into contact with the surface of the substrate and capillary action between the outlets and the surface of the substrate will cause a droplet of liquid to be loaded from each outlet onto the surface.Type: ApplicationFiled: March 26, 2015Publication date: September 29, 2016Inventor: Per Ove ÖHMAN
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Publication number: 20150031586Abstract: There is provided an assay device comprising a lid and a base, said base comprising, a sample addition zone, a reaction zone and an absorbing zone, said components being in fluid connection and being part of a fluid passage leading from the sample addition zone to the absorbing zone, wherein: (a) a sample addition well is integrated in the lid, (b) the absorbing zone consists of an area on an non-porous substrate, having substantially perpendicular projections, said projections defining a volume, which together with the volume of the fluid passage defines the sample volume subjected to the assay, and (c) at least one filter is between the sample addition well and the sample addition zone. There is further provided methods for handling samples.Type: ApplicationFiled: October 6, 2014Publication date: January 29, 2015Inventors: Per Ove Öhman, Ib Mendel-Hartvig
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Patent number: 8877142Abstract: There is provided an assay device comprising a lid and a base, said base comprising, a sample addition zone, a reaction zone and an absorbing zone, said components being in fluid connection and being part of a fluid passage leading from the sample addition zone to the absorbing zone, wherein: (a) a sample addition well is integrated in the lid, (b) the absorbing zone consists of an area on an non-porous substrate, having substantially perpendicular projections, said projections defining a volume, which together with the volume of the fluid passage defines the sample volume subjected to the assay, and (c) at least one filter is between the sample addition well and the sample addition zone. There is further provided methods for handling samples.Type: GrantFiled: June 20, 2007Date of Patent: November 4, 2014Assignee: Johnson & Johnson ABInventors: Per Ove Öhman, Ib Mendel-Hartvig
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Patent number: 8821812Abstract: An absorbing zone for establishing and/or maintaining fluid transport through or along at least one fluid passage is manufactured on the basis of a non-porous substrate having a surface, the non-porous substrate having projections substantially perpendicular to the surface, and the projections having a height, diameter and a distance or distances between the projections such, that lateral capillary flow of the fluid in the zone is achieved.Type: GrantFiled: June 19, 2006Date of Patent: September 2, 2014Assignee: Johnson & Johnson ABInventors: Per Ove Öhman, Ib Mendel-Hartvig
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Patent number: 8409523Abstract: An analysis device having at least one sample addition zone, at least one sink, and at least one flow path connecting the at least one sample addition zone and the at least one sink. The at least one flow path includes projections substantially vertical to the surface of the substrate and having a height (H), diameter (D) and reciprocal spacing (t1, t2) such that lateral capillary flow of a liquid sample is achieved. The device includes at least two reaction zones in series, wherein each reaction zone is adapted to facilitating measurement of a response originating from one and the same analyte, and wherein the reaction zones are positioned to allow calculation of the concentration of at least one analyte. Advantages include that a more accurate value can be calculated, variations are reduced, and an estimation of the uncertainty of the response can be calculated.Type: GrantFiled: July 1, 2010Date of Patent: April 2, 2013Assignee: Amic ABInventors: Ib Mendel-Hartvig, Gerd Rundström, Per Ove Öhman
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Patent number: 8343439Abstract: The present invention provides an assay device for performing an assay on a liquid sample using a detection conjugate capable of binding to an antigen and containing a label, said device comprising a substrate having a substrate surface, wherein the surface comprises projections substantially perpendicular to said surface, said projections having a height, diameter and distance capable of generating lateral capillary flow of a fluid in said passage, said surface comprising a sample addition zone, a reaction zone and an absorbing zone, said zones being connected by at least one fluid passage, wherein said device has a first functionality verifying feature located between the sample addition zone and the reaction zone, and a second functionality verifying feature located within the absorbing zone, and both functionality verifying features being features capable of undergoing a detectable change when contacted by the sample, said assay device further comprising at least one alignment verification zone.Type: GrantFiled: June 20, 2007Date of Patent: January 1, 2013Assignee: AMIC ABInventors: Per Ove Öhman, Ib Mendel-Hartvig, Tomas Lindström
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Publication number: 20110003398Abstract: An analysis device having at least one sample addition zone, at least one sink, and at least one flow path connecting the at least one sample addition zone and the at least one sink. The at least one flow path includes projections substantially vertical to the surface of the substrate and having a height (H), diameter (D) and reciprocal spacing (t1, t2) such that lateral capillary flow of a liquid sample is achieved. The device includes at least two reaction zones in series, wherein each reaction zone is adapted to facilitating measurement of a response originating from one and the same analyte, and wherein the reaction zones are positioned to allow calculation of the concentration of at least one analyte. Advantages include that a more accurate value can be calculated, variations are reduced, and an estimation of the uncertainty of the response can be calculated.Type: ApplicationFiled: July 1, 2010Publication date: January 6, 2011Applicant: AMIC ABInventors: Ib Mendel-Hartvig, Gerd Rundström, Per Ove Öhman
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Publication number: 20100041154Abstract: The present invention provides an assay device for performing an assay on a liquid sample using a detection conjugate capable of binding to an antigen and containing a label, said device comprising a substrate having a substrate surface, wherein the surface comprises projections substantially perpendicular to said surface, said projections having a height, diameter and distance capable of generating lateral capillary flow of a fluid in said passage, said surface comprising a sample addition zone, a reaction zone and an absorbing zone, said zones being connected by at least one fluid passage, wherein said device has a first functionality verifying feature located between the sample addition zone and the reaction zone, and a second functionality verifying feature located within the absorbing zone, and both functionality verifying features being features capable of undergoing a detectable change when contacted by the sample, said assay device further comprising at least one alignment verification zone.Type: ApplicationFiled: June 20, 2007Publication date: February 18, 2010Applicant: AMIC ABInventors: Per Ove Öhman, Ib Mendel-Hartvig, Tomas Lindström
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Publication number: 20090208920Abstract: There is provided an assay device comprising a lid and a base, said base comprising, a sample addition zone, a reaction zone and an absorbing zone, said components being in fluid connection and being part of a fluid passage leading from the sample addition zone to the absorbing zone, wherein: (a) a sample addition well is integrated in the lid, (b) the absorbing zone consists of an area on an non-porous substrate, having substantially perpendicular projections, said projections defining a volume, which together with the volume of the fluid passage defines the sample volume subjected to the assay, and (c) at least one filter is between the sample addition well and the sample addition zone. There is further provided methods for handling samples.Type: ApplicationFiled: June 20, 2007Publication date: August 20, 2009Inventors: Per Ove Öhman, Ib Mendel-Hartvig
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Patent number: 7213339Abstract: Method of manufacturing a microscale nozzle, comprising the steps of forming a microscale channel in the top surface of a substrate, said microscale channel comprising an inlet end and a nozzle-end, depositing a nozzle-forming layer in a section of the microscale channel, and removing material from the substrate at the nozzle-end of the microscale channel to expose at least a portion of said nozzle-forming layer. The manufactured microscale nozzle may be used for transferring a liquid sample form a microchip fluidic system into an external analytical device.Type: GrantFiled: December 12, 2001Date of Patent: May 8, 2007Assignees: Gyros AB, Amic ABInventors: Per Ove Öhman, Per Andersson
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Patent number: 7182890Abstract: The invention relates to a matrix suitable for use in the replication of a plastic element having a positive microstructure, comprising a first wear-resistant layer that is supported by a carrier element, wherein the matrix comprises a heating means for supplying electrical heat energy through the wear-resistant layer or carrier element. The invention further relates to a plastic element producing machine and a method for the manufacture of a plastic element having a surface with a positive microstructure.Type: GrantFiled: December 2, 2004Date of Patent: February 27, 2007Assignees: Gyros Patent AB, Åmic ABInventors: Per Ove Öhman, Lars Rune Lundbladh
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Patent number: 6884370Abstract: The invention relates to a matrix suitable for use in the replication of a plastic element having a positive microstructure, comprising a first wear-resistant layer that is supported by a carrier element, wherein the matrix comprises a heating means for supplying electrical heat energy through the wear-resistant layer or carrier element. The invention further relates to a plastic element producing machine and a method for the manufacture of a plastic element having a surface with a positive microstructure.Type: GrantFiled: August 2, 2002Date of Patent: April 26, 2005Assignees: Amic AB, Gyros ABInventors: Per Ove Öhman, Lars Rune Lundbladh
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Patent number: 6663744Abstract: Method and device for heat treatment of a disc, whereby the disc (1) is placed on a carrier (14) after which the disc is irradiated. During the radiation the carrier is kept on a desired temperature. The desired temperature of the carrier is about the temperature of the disc prior to placement on the carrier. The disc comprises two disc elements and an adhesive layer between the disc elements, whereby the adhesive layer is cured by the irradiation with ultraviolet light.Type: GrantFiled: November 6, 2000Date of Patent: December 16, 2003Assignee: OTB Group B.V.Inventors: Lars Gustaf Magnus Bering, Rolf Tommy Nils Karlsson, Claes Lannart Eriksson, Lars Göran Eriksson, Per Ove Öhman
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Patent number: 6454970Abstract: The invention relates to a method of producing a matrix suitable for use in a plastic element-producing machine, a matrix produced in accordance with the method and use of such a matrix to form a plastic element. One side of the matrix is provided with a negative microstructure which is replicated in plastic material to form a positive microstructure on a plastic element, wherewith the matrix can be produced by applying a layer of material to the positive microstructure side of a master. The positive microstructure side of the master has a thin wear-resistant layer which serves as a first wear surface, wherewith said layer will present irregularities which correspond essentially to the microstructure, and wherein at least said irregularities are filled-in with a plastic composite so as to form a carrier element for supporting the first wear layer. The layer can further be provided with means for supplying heat energy to said matrix.Type: GrantFiled: July 19, 2000Date of Patent: September 24, 2002Assignee: AMIC AB and Gyros ABInventors: Per Ove Öhman, Lars Rune Lundbladh
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Patent number: 6372542Abstract: The present invention relates to a method of producing an electric, electronic, electromechanical and/or mechanical component (12), where the component substrate is given a three-dimensional structure (3″) or configuration, and where said substrate is adapted for further treatment or processing to form the component (12). The substrate is formed by shaping said substrate against a die or mold, such as by molding, pressing, extruding or embossing said substrate, wherewith the precision necessary with respect to said component in the three-dimensional structure is achieved by means of a micromechanical working process when producing the die or mold.Type: GrantFiled: October 19, 2000Date of Patent: April 16, 2002Assignee: Åmic ABInventors: Hans Göran Evald Martin, Per Ove Öhman