Patents by Inventor Per Ove Ohman
Per Ove Ohman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20190145966Abstract: Disclosed is an analytical device including at least one non-binding membrane; at least one liquid sample application region; and at least one capturing chamber including labelled particles; in which device the sample application region(s) are arranged upstream of the membrane while the capturing chamber(s) are arranged downstream of the membrane, and wherein the cut-off of the membrane is large enough to allow passage of labelled particles but small enough to retain clusters including analyte bound to particles. Also disclosed is a method of detecting one or more analytes such as biomarkers in a liquid sample such as blood using a device as disclosed.Type: ApplicationFiled: April 11, 2017Publication date: May 16, 2019Applicant: MEJE ABInventor: Per Ove ÖHMAN
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Patent number: 9606112Abstract: There is provided an assay device comprising a lid and a base, said base comprising, a sample addition zone, a reaction zone and an absorbing zone, said components being in fluid connection and being part of a fluid passage leading from the sample addition zone to the absorbing zone, wherein: (a) a sample addition well is integrated in the lid, (b) the absorbing zone consists of an area on an non-porous substrate, having substantially perpendicular projections, said projections defining a volume, which together with the volume of the fluid passage defines the sample volume subjected to the assay, and (c) at least one filter is between the sample addition well and the sample addition zone. There is further provided methods for handling samples.Type: GrantFiled: October 6, 2014Date of Patent: March 28, 2017Assignee: JOHNSON & JOHNSON ABInventors: Per Ove Öhman, Ib Mendel-Hartvig
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Publication number: 20160279590Abstract: A system is provided for dispensing a plurality of droplets substantially simultaneously onto a substrate (51). The liquids are stored in wells in a manifold plate (1) and transferred via micro capillaries to a transfer block (31). The transfer block comprises capillary through channels (33) which lead to outlets (41). The transfer block can be moved so that outlets can be brought into contact with the surface of the substrate and capillary action between the outlets and the surface of the substrate will cause a droplet of liquid to be loaded from each outlet onto the surface.Type: ApplicationFiled: March 26, 2015Publication date: September 29, 2016Inventor: Per Ove ÖHMAN
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Publication number: 20150031586Abstract: There is provided an assay device comprising a lid and a base, said base comprising, a sample addition zone, a reaction zone and an absorbing zone, said components being in fluid connection and being part of a fluid passage leading from the sample addition zone to the absorbing zone, wherein: (a) a sample addition well is integrated in the lid, (b) the absorbing zone consists of an area on an non-porous substrate, having substantially perpendicular projections, said projections defining a volume, which together with the volume of the fluid passage defines the sample volume subjected to the assay, and (c) at least one filter is between the sample addition well and the sample addition zone. There is further provided methods for handling samples.Type: ApplicationFiled: October 6, 2014Publication date: January 29, 2015Inventors: Per Ove Öhman, Ib Mendel-Hartvig
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Patent number: 8877142Abstract: There is provided an assay device comprising a lid and a base, said base comprising, a sample addition zone, a reaction zone and an absorbing zone, said components being in fluid connection and being part of a fluid passage leading from the sample addition zone to the absorbing zone, wherein: (a) a sample addition well is integrated in the lid, (b) the absorbing zone consists of an area on an non-porous substrate, having substantially perpendicular projections, said projections defining a volume, which together with the volume of the fluid passage defines the sample volume subjected to the assay, and (c) at least one filter is between the sample addition well and the sample addition zone. There is further provided methods for handling samples.Type: GrantFiled: June 20, 2007Date of Patent: November 4, 2014Assignee: Johnson & Johnson ABInventors: Per Ove Öhman, Ib Mendel-Hartvig
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Patent number: 8821812Abstract: An absorbing zone for establishing and/or maintaining fluid transport through or along at least one fluid passage is manufactured on the basis of a non-porous substrate having a surface, the non-porous substrate having projections substantially perpendicular to the surface, and the projections having a height, diameter and a distance or distances between the projections such, that lateral capillary flow of the fluid in the zone is achieved.Type: GrantFiled: June 19, 2006Date of Patent: September 2, 2014Assignee: Johnson & Johnson ABInventors: Per Ove Öhman, Ib Mendel-Hartvig
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Patent number: 8759115Abstract: An assay device for performing an assay on a liquid sample using a detection conjugate capable of binding to an antigen and containing a label. The device includes a substrate surface having a sample addition zone, a reaction zone and an absorbing zone, the zones being connected by at least one fluid passage, wherein the device has a first functionality verifying feature located between the sample addition zone and the reaction zone, and a second functionality verifying feature located within the absorbing zone. Both functionality verifying features are capable of undergoing a detectable change when contacted by the sample, in which the assay device further includes at least one alignment verification zone. There is further provided a kit of parts and a method of conducting an assay.Type: GrantFiled: December 12, 2012Date of Patent: June 24, 2014Assignee: Johnson & Johnson ABInventors: Per Ove Ohman, Ib Mendel-Hartvig, Tomas Lindstrom
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Patent number: 8753585Abstract: A device for handling liquid samples, comprising a flow path with at least one zone for receiving the sample, and a transport or incubation zone, said zones connected by or comprising an area having projections substantially vertical to its surface, said device provided with a sink with a capacity of receiving said liquid sample, said sink comprising an area having projections substantially vertical to its surface, and said sink being adapted to respond to an external influence regulating its capacity to receive said liquid sample.Type: GrantFiled: June 8, 2010Date of Patent: June 17, 2014Assignee: Johnson & Johnson ABInventors: Per Ove Ohman, Ib Mendel-Hartvig
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Patent number: 8409523Abstract: An analysis device having at least one sample addition zone, at least one sink, and at least one flow path connecting the at least one sample addition zone and the at least one sink. The at least one flow path includes projections substantially vertical to the surface of the substrate and having a height (H), diameter (D) and reciprocal spacing (t1, t2) such that lateral capillary flow of a liquid sample is achieved. The device includes at least two reaction zones in series, wherein each reaction zone is adapted to facilitating measurement of a response originating from one and the same analyte, and wherein the reaction zones are positioned to allow calculation of the concentration of at least one analyte. Advantages include that a more accurate value can be calculated, variations are reduced, and an estimation of the uncertainty of the response can be calculated.Type: GrantFiled: July 1, 2010Date of Patent: April 2, 2013Assignee: Amic ABInventors: Ib Mendel-Hartvig, Gerd Rundström, Per Ove Öhman
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Patent number: 8343439Abstract: The present invention provides an assay device for performing an assay on a liquid sample using a detection conjugate capable of binding to an antigen and containing a label, said device comprising a substrate having a substrate surface, wherein the surface comprises projections substantially perpendicular to said surface, said projections having a height, diameter and distance capable of generating lateral capillary flow of a fluid in said passage, said surface comprising a sample addition zone, a reaction zone and an absorbing zone, said zones being connected by at least one fluid passage, wherein said device has a first functionality verifying feature located between the sample addition zone and the reaction zone, and a second functionality verifying feature located within the absorbing zone, and both functionality verifying features being features capable of undergoing a detectable change when contacted by the sample, said assay device further comprising at least one alignment verification zone.Type: GrantFiled: June 20, 2007Date of Patent: January 1, 2013Assignee: AMIC ABInventors: Per Ove Öhman, Ib Mendel-Hartvig, Tomas Lindström
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Publication number: 20110003398Abstract: An analysis device having at least one sample addition zone, at least one sink, and at least one flow path connecting the at least one sample addition zone and the at least one sink. The at least one flow path includes projections substantially vertical to the surface of the substrate and having a height (H), diameter (D) and reciprocal spacing (t1, t2) such that lateral capillary flow of a liquid sample is achieved. The device includes at least two reaction zones in series, wherein each reaction zone is adapted to facilitating measurement of a response originating from one and the same analyte, and wherein the reaction zones are positioned to allow calculation of the concentration of at least one analyte. Advantages include that a more accurate value can be calculated, variations are reduced, and an estimation of the uncertainty of the response can be calculated.Type: ApplicationFiled: July 1, 2010Publication date: January 6, 2011Applicant: AMIC ABInventors: Ib Mendel-Hartvig, Gerd Rundström, Per Ove Öhman
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Publication number: 20100248394Abstract: A device for handling liquid samples, comprising a flow path with at least one zone for receiving the sample, and a transport or incubation zone, said zones connected by or comprising an area having projections substantially vertical to its surface, said device provided with a sink with a capacity of receiving said liquid sample, said sink comprising an area having projections substantially vertical to its surface, and said sink being adapted to respond to an external influence regulating its capacity to receive said liquid sample.Type: ApplicationFiled: June 8, 2010Publication date: September 30, 2010Applicant: AMIC ABInventors: Per Ove Ohman, Ib Mendel-Hartvig
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Publication number: 20100041154Abstract: The present invention provides an assay device for performing an assay on a liquid sample using a detection conjugate capable of binding to an antigen and containing a label, said device comprising a substrate having a substrate surface, wherein the surface comprises projections substantially perpendicular to said surface, said projections having a height, diameter and distance capable of generating lateral capillary flow of a fluid in said passage, said surface comprising a sample addition zone, a reaction zone and an absorbing zone, said zones being connected by at least one fluid passage, wherein said device has a first functionality verifying feature located between the sample addition zone and the reaction zone, and a second functionality verifying feature located within the absorbing zone, and both functionality verifying features being features capable of undergoing a detectable change when contacted by the sample, said assay device further comprising at least one alignment verification zone.Type: ApplicationFiled: June 20, 2007Publication date: February 18, 2010Applicant: AMIC ABInventors: Per Ove Öhman, Ib Mendel-Hartvig, Tomas Lindström
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Publication number: 20090208920Abstract: There is provided an assay device comprising a lid and a base, said base comprising, a sample addition zone, a reaction zone and an absorbing zone, said components being in fluid connection and being part of a fluid passage leading from the sample addition zone to the absorbing zone, wherein: (a) a sample addition well is integrated in the lid, (b) the absorbing zone consists of an area on an non-porous substrate, having substantially perpendicular projections, said projections defining a volume, which together with the volume of the fluid passage defines the sample volume subjected to the assay, and (c) at least one filter is between the sample addition well and the sample addition zone. There is further provided methods for handling samples.Type: ApplicationFiled: June 20, 2007Publication date: August 20, 2009Inventors: Per Ove Öhman, Ib Mendel-Hartvig
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Patent number: 7564045Abstract: An optical reader for an optical assay arrangement including a polymeric sample substrate having a reaction-site surface provided with protruding microstructures and at least one reaction-site area; a light source for illuminating the reaction-site area; and a detector device for detecting light emitted from the reaction-site area. The light source is arranged to inject exciting light rays into the polymeric sample substrate with a controlled angle of incidence such that the protruding microstructures guide the exciting light rays in the direction of the reaction-site area, and the detector device detects light emitted from the at least one reaction-site area.Type: GrantFiled: June 15, 2006Date of Patent: July 21, 2009Assignee: AMIC ABInventors: Per Ove Ohman, Tomas Lindstrom, Ib Mendel-Hartvig
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Patent number: 7213339Abstract: Method of manufacturing a microscale nozzle, comprising the steps of forming a microscale channel in the top surface of a substrate, said microscale channel comprising an inlet end and a nozzle-end, depositing a nozzle-forming layer in a section of the microscale channel, and removing material from the substrate at the nozzle-end of the microscale channel to expose at least a portion of said nozzle-forming layer. The manufactured microscale nozzle may be used for transferring a liquid sample form a microchip fluidic system into an external analytical device.Type: GrantFiled: December 12, 2001Date of Patent: May 8, 2007Assignees: Gyros AB, Amic ABInventors: Per Ove Öhman, Per Andersson
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Patent number: 7182890Abstract: The invention relates to a matrix suitable for use in the replication of a plastic element having a positive microstructure, comprising a first wear-resistant layer that is supported by a carrier element, wherein the matrix comprises a heating means for supplying electrical heat energy through the wear-resistant layer or carrier element. The invention further relates to a plastic element producing machine and a method for the manufacture of a plastic element having a surface with a positive microstructure.Type: GrantFiled: December 2, 2004Date of Patent: February 27, 2007Assignees: Gyros Patent AB, Åmic ABInventors: Per Ove Öhman, Lars Rune Lundbladh
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Patent number: 6884370Abstract: The invention relates to a matrix suitable for use in the replication of a plastic element having a positive microstructure, comprising a first wear-resistant layer that is supported by a carrier element, wherein the matrix comprises a heating means for supplying electrical heat energy through the wear-resistant layer or carrier element. The invention further relates to a plastic element producing machine and a method for the manufacture of a plastic element having a surface with a positive microstructure.Type: GrantFiled: August 2, 2002Date of Patent: April 26, 2005Assignees: Amic AB, Gyros ABInventors: Per Ove Öhman, Lars Rune Lundbladh
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Patent number: 6811736Abstract: A method of producing a plastic product having a microstructured surface (3a), utilizing an arrangement for moulding plastic products. Said arrangement has at least two mould parts (2, 3) movable towards and away from each other, a predetermined volume of a viscous polymerizable plastic material (9) being supplied to a cavity formed between the mould parts, after which polymerization of the plastic material occurs. After said polymerization of the plastic material (9′), the mould parts are caused to move apart from each other thereby allowing removal of a finished plastic product the outer shape of which conforms to the shape of the cavity produced by the mould parts. Said viscous polymerizable plastic material (9) is supplied to the cavity (6) around a hole (10a) pertaining to the finished plastic product, and said viscous plastic material is distributed in a direction from said hole (10a) towards the peripheral edge area of the plastic product.Type: GrantFiled: February 26, 2002Date of Patent: November 2, 2004Assignees: Gyros AB, Amic ABInventors: Per Ove Ohman, Lars Rune Lundbladh
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Publication number: 20040055136Abstract: Method of manufacturing a microscale nozzle (52), comprising the steps of forming a microscale channel (32) in the top surface (34) of a substrate (30), said microscale channel (32) comprising an inlet end (36) and a nozzle-end (38), depositing a nozzle-forming layer (50) in a section of the microscale channel (32), removing material from the substrate (30) at the nozzle-end (38) of the microscale channel (32) to expose at least a portion of said nozzle-forming layer (50). The manufactured microscale nozzle may be used for transferring a liquid sample form a microchip fluidic system into an external analytical device. Whereby the transfer is performed by droplet, spray or steam.Type: ApplicationFiled: June 11, 2003Publication date: March 25, 2004Inventors: Per Ove Ohman, Per Andersson