Abstract: The present disclosure relates to the treatment of hand eczema. The problem to be solved by the disclosure is to provide a new pharmaceutical use of 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3,4]octan-1-yl]-3-oxopropanenitrile. A therapeutic or preventive agent for hand eczema, containing 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3,4]octan-1-yl]-3-oxopropanenitrile as an active ingredient.

Abstract: The present invention relates to the treatment of hand eczema. The problem to be solved by the invention is to provide a new pharmaceutical use of 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile. A therapeutic or preventive agent for hand eczema, containing 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1,6-diazaspiro[3.4]octan-1-yl]-3-oxopropanenitrile as an active ingredient.

Abstract: A probe pin (100, 100?) for electronic testing of semi-conductor elements is provided. The pin contains an electrically conductive core element (200) made up of a metallic alloy, and an electrically insulating jacket element (300) which surrounds the core element (200) over regions thereof. The core element (200) contains a distal contact section (210) for electrical contacting to a semi-conductor element. The metallic alloy of the core element contains at least 67% by weight rhodium, 0.1% by weight to 1% by weight zirconium, up to 1% by weight yttrium, and up to 1% by weight cerium. A method for producing a probe pin is also described.

Abstract: The present invention relates to nalmefene for use in the reduction of alcohol consumption in a patient with alcohol dependence who has a high drinking risk level. The present invention also relates to nalmefene for use in the reduction of alcohol consumption in a patient with alcohol dependence who maintains a high DRL after an observation period following initial assessment.

Abstract: The present invention relates to nalmefene for use in the reduction of alcohol consumption in a patient with alcohol dependence who has a high drinking risk level. The present invention also relates to nalmefene for use in the reduction of alcohol consumption in a patient with alcohol dependence who maintains a high DRL after an observation period following initial assessment.

Abstract: A probe pin (100, 100?) for electronic testing of semi-conductor elements is provided. The pin contains an electrically conductive core element (200) made up of a metallic alloy, and an electrically insulating jacket element (300) which surrounds the core element (200) over regions thereof. The core element (200) contains a distal contact section (210) for electrical contacting to a semi-conductor element. The metallic alloy of the core element contains at least 67% by weight rhodium, 0.1% by weight to 1% by weight zirconium, up to 1% by weight yttrium, and up to 1% by weight cerium. A method for producing a probe pin is also described.

Abstract: The present invention relates to nalmefene for use in the reduction of alcohol consumption in a patient with alcohol dependence who has a high drinking risk level. The present invention also relates to nalmefene for use in the reduction of alcohol consumption in a patient with alcohol dependence who maintains at least medium DRL after an observation period following initial assessment.

Abstract: The invention relates to a device for controlled conveying of products (2), such as drinks cans or bottles from an intake (3) at a first height level to an outlet (5) at a second height level. The device comprises a substantially vertical conveyor duct (4), which is arranged to contain a plurality of axially stacked products (2) and which forms a transport path from the intake (3) to the outlet (5), a sensor device arranged to provide a signal expressing that a product has been removed from the outlet (5) conveyor devices, arranged to perform a repeatable convey cycle for controlled conveying of a product to the outlet, and a control device, arranged to implement the convey cycle on the basis of the said signal. In a preferred embodiment the conveyor device' comprises a seat (6) which protrudes through a gap extending in the conveyor duct's longitudinal direction, and which is controllably movable in the conveyor duct's longitudinal direction, and in addition a blocking device (7).

Abstract: The invention relates to a transport system for refrigerated products such as mineral water cans or bottles, comprising a supply device and a discharge device, wherein the supply device is located, e.g., in a store and the discharge device is located, e.g., in sales premises, where the system also comprises a transport arrangement between the suply device and the discharge device. The invention is characterized in that the system further comprises a cold storage plant for the products.