Patents by Inventor Periannan Kuppusamy
Periannan Kuppusamy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10722138Abstract: Electron paramagnetic resonance (EPR) systems and methods for transcutaneous oxygen monitoring (TCOM) and subcutaneous oxygen monitoring (SCOM) are provided herein. Optionally, the EPR systems provided herein can be portable and/or handheld to facilitate EPR oximetry in clinical environments.Type: GrantFiled: June 11, 2015Date of Patent: July 28, 2020Assignee: Technion Research & Development Foundation LimitedInventors: Aharon Blank, Periannan Kuppusamy, Ahmad Rizwan
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Publication number: 20170105651Abstract: Electron paramagnetic resonance (EPR) systems and methods for transcutaneous oxygen monitoring (TCOM) and subcutaneous oxygen monitoring (SCOM) are provided herein. Optionally, the EPR systems provided herein can be portable and/or handheld to facilitate EPR oximetry in clinical environments.Type: ApplicationFiled: June 11, 2015Publication date: April 20, 2017Inventors: Aharon BLANK, Periannan KUPPUSAMY, Ahmad RIZWAN
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Publication number: 20140170073Abstract: A new class of micro- and nano-particulate paramagnetic spin probes especially useful for magnetic resonance imaging techniques, including electron paramagnetic resonance (EPR) and magnetic resonance imaging (MRI). The probes are lithium phthalocyanine derivative compounds. Also provided are suspensions and emulsions comprising lithium phthalocyanine derivative probes. Also provided are noninvasive methods for measuring noninvasive methods of measuring oxygen concentration, oxygen partial pressure, oxygen metabolism, and nitric oxide concentration in a specific tissue, organ, or cell in vivo or in vitro.Type: ApplicationFiled: August 30, 2013Publication date: June 19, 2014Applicant: The Ohio State University Research FoundationInventors: Periannan Kuppusamy, Ramasamy P. Pandian, Narasimham L. Parinandi, Jay L. Zweier
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Patent number: 8722707Abstract: Compositions and methods for treating post angioplasty restenosis, arteriosclerosis, and/or smooth muscle cell proliferation and/or neointimal hyperplasia in vascular tissues, and at least one composition of a redox based curcumin derivative, DAP-F(p) and a pharmaceutically acceptable carrier, are described.Type: GrantFiled: July 6, 2010Date of Patent: May 13, 2014Assignee: The Ohio State UniversityInventors: Periannan Kuppusamy, Kalman Hideg, Karuppaiyah Selvendiran
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Patent number: 8568694Abstract: A new class of micro- and nano-particulate paramagnetic spin probes especially useful for magnetic resonance imaging techniques, including electron paramagnetic resonance (EPR) and magnetic resonance imaging (MRI). The probes are lithium phthalocyanine derivative compounds. Also provided are suspensions and emulsions comprising lithium phthalocyanine derivative probes. Also provided are noninvasive methods for measuring noninvasive methods of measuring oxygen concentration, oxygen partial pressure, oxygen metabolism, and nitric oxide concentration in a specific tissue, organ, or cell in vivo or in vitro.Type: GrantFiled: January 15, 2010Date of Patent: October 29, 2013Assignee: The Ohio State University Research FoundationInventors: Periannan Kuppusamy, Ramasamy P. Pandian, Narasimham L. Parinandi, Jay L. Zweier
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Patent number: 8569482Abstract: A new class of micro- and nano-particulate paramagnetic spin probes useful for magnetic resonance imaging techniques, including electron paramagnetic resonance (EPR) and magnetic resonance imaging (MRI). The probes are lithium phthalocyanine derivative compounds. Also provided are suspensions and emulsions comprising lithium phthalocyanine derivative probes. Also provided are noninvasive methods for measuring noninvasive methods of measuring oxygen concentration, oxygen partial pressure, oxygen metabolism, and nitric oxide concentration in a specific tissue, organ, or cell in vivo or in vitro.Type: GrantFiled: November 29, 2011Date of Patent: October 29, 2013Assignee: The Ohio State University Research FoundationInventors: Periannan Kuppusamy, Vijay Kutala, Jay L. Zweier, Pawel Kwiatkowski
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Publication number: 20130127466Abstract: A scanner for assessing localized oxygenation of a desired region of interest includes a handheld housing having a proximal end and a distal end. A resonator coil is disposed within the housing and also disposed adjacent the distal end of the housing. The resonator coil is configured to both excite and read paramagnetic materials. A magnet is disposed within the housing and also disposed adjacent the distal end of the housing. The magnet is configured to provide a substantially uniform magnetic field over the desired region of interest. The scanner is configured to use electron paramagnetic resonance to assess localized oxygenation in the desired region.Type: ApplicationFiled: May 25, 2012Publication date: May 23, 2013Applicant: 02 Insights, Inc.Inventors: Periannan Kuppusamy, Samit Kumar Gupta, Robert Lawrence Rushenberg
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Publication number: 20120316203Abstract: Methods and compositions for treating cancers, including ovarian cancers, are described. The compositions generally include a redox based curcumin derivative, diarylidenylpiperiden-4-one (DAP) having a hydroxylamine moiety attached thereto.Type: ApplicationFiled: July 6, 2010Publication date: December 13, 2012Applicant: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATIONInventors: Periannan Kuppusamy, Kalman Hideg
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Publication number: 20120296188Abstract: A sensor for measuring oxygen concentration in a tissue or an organ of a subject is provided. The sensor includes a sensory element comprising at least one paramagnetic spin probe compound encapsulated in a biocompatible oxygen permeable material. A barrier layer partially covers the sensory element and is comprised of at least one biocompatible oxygen impermeable material. Oxygen concentration data may be acquired by applying the sensor to the tissue or the organ of the subject, and subsequently applying a magnetic resonance spectroscopy or imaging technique.Type: ApplicationFiled: May 16, 2012Publication date: November 22, 2012Applicant: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATIONInventors: PERIANNAN KUPPUSAMY, BRIAN RIVERA, EDWARD ETESHOLA, GURUGUHAN MEENAKSHISUNDARAM
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Patent number: 8066973Abstract: A new class of micro- and nano- particulate paramagnetic spin probes useful for magnetic resonance imaging techniques, including electron paramagnetic resonance (EPR) and magnetic resonance imaging (MRI). The probes are lithium phthalocyanine derivative compounds. Also provided are suspensions and emulsions comprising lithium phthalocyanine derivative probes. Also provided are noninvasive methods for measuring noninvasive methods of measuring oxygen concentration, oxygen partial pressure, oxygen metabolism, and nitric oxide concentration in a specific tissue, organ, or cell in vivo or in vitro.Type: GrantFiled: March 1, 2006Date of Patent: November 29, 2011Assignee: The Ohio State University Research FoundationInventors: Periannan Kuppusamy, Vijay Kutala, Jay L. Zweier, Pawel Kwiatkowski
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Publication number: 20100172843Abstract: A new class of micro- and nano-particulate paramagnetic spin probes especially useful for magnetic resonance imaging techniques, including electron paramagnetic resonance (EPR) and magnetic resonance imaging (MRI). The probes are lithium phthalocyanine derivative compounds. Also provided are suspensions and emulsions comprising lithium phthalocyanine derivative probes. Also provided are noninvasive methods for measuring noninvasive methods of measuring oxygen concentration, oxygen partial pressure, oxygen metabolism, and nitric oxide concentration in a specific tissue, organ, or cell in vivo or in vitro.Type: ApplicationFiled: January 15, 2010Publication date: July 8, 2010Applicant: THE OHIO STATE UNIVERSITY RESEARCH FOUNDATIONInventors: Periannan Kuppusamy, Ramasamy P. Pandian, Narasimham L. Parinandi, Jay L. Zweier
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Patent number: 7662362Abstract: A new class of micro- and nano-particulate paramagnetic spin probes especially useful for magnetic resonance imaging techniques, including electron paramagnetic resonance (EPR) and magnetic resonance imaging (MRI). The probes are lithium phthalocyanine derivative compounds. Also provided are suspensions and emulsions comprising lithium phthalocyanine derivative probes. Also provided are noninvasive methods for measuring noninvasive methods of measuring oxygen concentration, oxygen partial pressure, oxygen metabolism, and nitric oxide concentration in a specific tissue, organ, or cell in vivo or in vitro.Type: GrantFiled: September 7, 2004Date of Patent: February 16, 2010Assignee: The Ohio State University Research FoundationInventors: Periannan Kuppusamy, Ramasamy P. Pandian, Narasimham L. Parinandi, Jay L. Zweier
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Publication number: 20050203292Abstract: A new class of micro- and nano-particulate paramagnetic spin probes especially useful for magnetic resonance imaging techinques, including electron paramagnetic resonance (EPR) and magnetic resonance imaging (MRI). The probes are lithium phthalocyanine derivative compounds. Also provided are are suspensions and emulsions comprising lithium phthalocyanine derivative probes. Also provided are noninvasive methods for measuring noninvasive methods of measuring oxygen concentration, oxygen partial pressure, oxygen metabolism, and nitric oxide concentration in a specific tissue, organ, or cell in vivo or in vitro.Type: ApplicationFiled: September 7, 2004Publication date: September 15, 2005Inventors: Periannan Kuppusamy, Ramasamy Pandian, Narasimham Parinandi, Jay Zweier