Patents by Inventor Perry C. Heath

Perry C. Heath has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5945547
    Abstract: The compound 2-deoxy-2,2-difluoro-D-erythro-pentofuranos-1-ulose-3,5-dibenzoate is described and claimed.
    Type: Grant
    Filed: March 19, 1997
    Date of Patent: August 31, 1999
    Assignee: Eli Lilly and Company
    Inventors: Ta-Sen Chou, Perry C. Heath
  • Patent number: 5578720
    Abstract: This invention provides for crystalline hydrochloride C.sub.1 -C.sub.3 alcohol solvate forms of the compound of formula (I): ##STR1## In particular, crystalline hydrochloride ethanol, methanol, and propanol solvates are disclosed.
    Type: Grant
    Filed: May 18, 1995
    Date of Patent: November 26, 1996
    Assignee: Eli Lilly and Company
    Inventors: Jane G. Amos, Perry C. Heath, Douglas E. Prather, John E. Toth
  • Patent number: 5574160
    Abstract: A 1-pot process for preparing 10b-methyl-3-oxo-benzo[f] quinolines.
    Type: Grant
    Filed: May 18, 1995
    Date of Patent: November 12, 1996
    Assignee: Eli Lilly and Company
    Inventors: James E. Audia, James J. Droste, Perry C. Heath, Leland O. Weigel
  • Patent number: 5550231
    Abstract: This invention provides for crystalline hydrochloride C.sub.1 -C.sub.3 alcohol solvate forms of the compound of formula (I): ##STR1## In particular, crystalline hydrochloride ethanol, methanol, and propanol solvates are disclosed. Also disclosed are processess for preparing and using the above compounds.
    Type: Grant
    Filed: June 15, 1993
    Date of Patent: August 27, 1996
    Assignee: Eli Lilly and Company
    Inventors: Jane G. Amos, Perry C. Heath, Douglas E. Prather, John E. Toth
  • Patent number: 5434254
    Abstract: The present invention provides a process for preparing lactone intermediates to 2',2'-difluoronucleosides whereby reversion back to the lactone's open chain precursor is minimized and the desired erythro enantiomer can be selectively isolated from an enantiomeric mixture of erythro and threo lactones in crystalline form. Also provided is a process for producing 2'-deoxy-2',2'-difluoronucleosides in about a 1:1 .alpha./.beta. anomeric ratio, and processes for selectively isolating .beta.-2'-deoxy-2',2'-difluorocytidine, or an organic or inorganic acid addition salt thereof, from the 1:1 .alpha./.beta. mixture.
    Type: Grant
    Filed: April 19, 1993
    Date of Patent: July 18, 1995
    Assignee: Eli Lilly and Company
    Inventors: Ta-Sen Chou, Perry C. Heath, Lawrence E. Patterson
  • Patent number: 5223608
    Abstract: The present invention provides a process for preparing lactone intermediates to 2',2'-difluoronucleosides whereby reversion back to the lactone's open chain precursor is minimized and the desired erythro enantiomer can be selectively isolated from an enantiomeric mixture of erythro and threo lactones in crystalline form. Also provided is a process for producing 2'-deoxy-2',2'-difluoronucleosides in about a 1:1 .alpha./.beta. anomeric ratio, and processes for selectively isolating .beta.-2'-deoxy-2',2'-difluorocytidine, or an organic or inorganic acid addition salt thereof, from the 1:1 .alpha./.beta. mixture.
    Type: Grant
    Filed: July 12, 1990
    Date of Patent: June 29, 1993
    Assignee: Eli Lilly and Company
    Inventors: Ta-Sen Chou, Perry C. Heath
  • Patent number: 4965374
    Abstract: The present invention provides a process for preparing lactone intermediates to 2',2'-difluoronucleosides whereby reversion back to the lactone's open chain precursor is minimized and the desired erythro enantiomer can be selectively isolated from an enantiomeric mixture of erythro and threo lactones in crystalline form. Also provided is a process for producing 2'-deoxy-2',2'-difluoronucleosides in about a 1:1 .alpha./.beta. anomeric ratio, and processes for selectively isolating .beta.-2'-deoxy-2',2'-difluorocytidine, or an organic or inorganic acid addition salt thereof, from the 1:1 .alpha./.beta. mixture.
    Type: Grant
    Filed: December 4, 1989
    Date of Patent: October 23, 1990
    Assignee: Eli Lilly and Company
    Inventors: Ta-Sen Chou, Perry C. Heath, Lawrence E. Patterson
  • Patent number: 4665168
    Abstract: 7-Amino-3-pyridiniummethyl (and substituted pyridiniummethyl)-3-cephem-4-carboxylic acid hydrothiocyanate salts and a process for the preparation thereof are provided. The salts are useful for recovering the pyridinium nuclei from reaction mixtures in which they are formed or used.
    Type: Grant
    Filed: April 14, 1986
    Date of Patent: May 12, 1987
    Assignee: Eli Lilly and Company
    Inventors: Ta-Sen Chou, Perry C. Heath
  • Patent number: 4525587
    Abstract: (6R,7R)-7-[(Z)-2-(2-triphenylmethylaminothiazol-4-yl)-2-(2-tert.-butoxycarb onylprop-2-oxyimino)acetamido]-3-(1-pyridiniummethyl)ceph-3-em-4-carboxylat e is isolated by formation of N,N-dimethylacetamide solvates.
    Type: Grant
    Filed: February 3, 1984
    Date of Patent: June 25, 1985
    Assignee: Eli Lilly and Company
    Inventors: Ta-Sen Chou, Perry C. Heath
  • Patent number: 4303591
    Abstract: Stannic chloride is removed from organic solvent-based waste streams by precipitating the salt as a dimethyl sulfoxide complex.
    Type: Grant
    Filed: July 7, 1980
    Date of Patent: December 1, 1981
    Assignee: Eli Lilly and Company
    Inventors: Ta-sen Chou, Perry C. Heath, Wayne D. Luke
  • Patent number: 4078089
    Abstract: Thixotropic fumigant compositions comprising liquid haloaliphatic hydrocarbon based fumigants and silica gelling agents may be stabilized through the use of an epoxide stabilizing agent and by controlling the purity of the raw materials such that the haloaliphatic hydrocarbon contains alcoholic impurities such as methyl alcohol in methyl bromide at a level of not more than about 200 ppm and such that the composition contains an initial water content of not more than about 500 ppm. Such compositions have utility as soil fumigants having significantly improved shelf life relative to prior gelled fumigant compositions for use in the control of nematodes, weeds, and weed seeds.
    Type: Grant
    Filed: April 19, 1977
    Date of Patent: March 7, 1978
    Assignee: Great Lakes Chemical Corporation
    Inventors: Robert P. Levek, Perry C. Heath