Patents by Inventor Perry V. Halushka

Perry V. Halushka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for treating and/or preventing sepsis and/or inflammatory conditions
    Patent number: 11938154
    Abstract: The presently disclosed subject matter relates to isolated compositions and methods for treating and/or preventing sepsis and inflammatory conditions, such as Acute Respiratory Distress Syndrome (ARDS). In some embodiments, the presently disclosed subject matter relates to endothelial progenitor cell-derived exosomes to treat and/or prevent sepsis and inflammatory conditions, such as Acute Respiratory Distress Syndrome (ARDS). The endothelial progenitor cell-derived exosomes can be modified to overexpress one or more miRNAs.
    Type: Grant
    Filed: February 27, 2019
    Date of Patent: March 26, 2024
    Assignee: MUSC Foundation for Research Development
    Inventors: Hongkuan Fan, Andrew Goodwin, Perry V. Halushka, James A Cook, Yue Zhou
  • COMPOSITIONS AND METHODS FOR TREATING AND/OR PREVENTING SEPSIS AND/OR INFLAMMATORY CONDITIONS
    Publication number: 20200390822
    Abstract: The presently disclosed subject matter relates to isolated compositions and methods for treating and/or preventing sepsis and inflammatory conditions, such as Acute Respiratory Distress Syndrome (ARDS). In some embodiments, the presently disclosed subject matter relates to endothelial progenitor cell-derived exosomes to treat and/or prevent sepsis and inflammatory conditions, such as Acute Respiratory Distress Syndrome (ARDS).
    Type: Application
    Filed: February 27, 2019
    Publication date: December 17, 2020
    Inventors: Hongkuan Fan, Andrew Goodwin, Perry V. Halushka, James A. Cook, Yue Zhou
  • DEVICES AND METHODS FOR CONCENTRATION AND ANALYSIS OF FLUIDS
    Publication number: 20130344588
    Abstract: Disclosed are articles, compositions and methods for detecting analytes. The disclosed articled, compositions and methods increase the ease of detection and quantitation of the target analyte.
    Type: Application
    Filed: November 10, 2011
    Publication date: December 26, 2013
    Applicant: MEDICAL UNIVERSITY OF SOUTH CAROLINA
    Inventors: Perry V. Halushka, Dennis K. Watson, Omar Moussa, Robert G. Dickie
  • Methods for the treatment of cancers
    Patent number: 8551489
    Abstract: Methods for the treatment of cancers involving dysregulation of thromboxane receptor ? (TP-?) are provided, including in certain aspects methods for diagnosing such cancers. Specific cancers included are genitourinary cancers, gastrointestinal cancers and leukemias.
    Type: Grant
    Filed: January 2, 2009
    Date of Patent: October 8, 2013
    Assignee: MUSC Foundation for Research Development
    Inventors: Omar Moussa, Dennis K. Watson, Perry V. Halushka
  • Methods for the diagnosis of genitourinary cancer
    Patent number: 8101371
    Abstract: Methods for the diagnosis of genitourinary (GU) cancer are provided. In particular, urine has been found to contain significant levels of thromboxane receptor ? (TP?) methods for diagnosing GU cancer. Methods for assessing treatment, prognosing and staging GU cancers, as well as kits therefor, also are provided.
    Type: Grant
    Filed: October 17, 2008
    Date of Patent: January 24, 2012
    Assignee: MUSC Foundation for Research Development
    Inventors: Omar Moussa, Dennis K. Watson, Perry V. Halushka
  • Methods for the Treatment of Cancers
    Publication number: 20110117078
    Abstract: Methods for the treatment of cancers involving dysregulation of thromboxane receptor ? (TP-?) are provided, including in certain aspects methods for diagnosing such cancers. Specific cancers included are genitourinary cancers, gastrointestinal cancers and leukemias.
    Type: Application
    Filed: January 2, 2009
    Publication date: May 19, 2011
    Inventors: Omar Moussa, Dennis K. Watson, Perry V. Halushka
  • METHODS FOR THE DIAGNOSIS OF GENITOURINARY CANCER
    Publication number: 20090136972
    Abstract: Methods for the diagnosis of genitourinary (GU) cancer are provided. In particular, urine has been found to contain significant levels of thromboxane receptor ? (TP?) methods for diagnosing GU cancer. Methods for assessing treatment, prognosing and staging GU cancers, as well as kits therefor, also are provided.
    Type: Application
    Filed: October 17, 2008
    Publication date: May 28, 2009
    Inventors: Omar Moussa, Dennis K. Watson, Perry V. Halushka
  • Platelet receptor antagonists useful in detecting intravascular platelet aggregation
    Patent number: 5334369
    Abstract: This invention provides novel compounds used in a method of determining platelet deposition. These compounds include .sup.123 I-SAP and analogues. Also provided is a method of determining platelet deposition in a subject comprising binding an effective radiolabeled platelet receptor antagonist with a platelet, allowing sufficient time for the platelet to migrate within the subject, and visualizing the radiolabeled platelet in the subject.
    Type: Grant
    Filed: June 11, 1991
    Date of Patent: August 2, 1994
    Assignee: Medical University of South Carolina
    Inventors: Perry V. Halushka, Ken M. Spicer, Dale E. Mais
  • Aromatic derivatives of 13-azaprostanoic acid
    Patent number: 4695647
    Abstract: Novel substituted phenyl eicosanoid analogs having the formula: ##STR1## and their pharmaceutically acceptable esters and salts, wherein: R is H or OH;R.sub.1 is H or lower alkyl;X is --CH.sub.2 --CH.sub.2 -- or cis --CH.dbd.CH--;Y is --CH.sub.2 --, ##STR2## --O-- or --S--; n is 0 or 1; and.circle.A is (1) an eicosanoid nucleus (ring system), (2) a carbocyclic analog of an eicosanoid nucleus or (3) a heterocyclic analog of an eicosanoid nucleus wherein one of the carbons in a carbocyclic analog is replaced by O, S or N.
    Type: Grant
    Filed: March 22, 1984
    Date of Patent: September 22, 1987
    Assignee: Drug Science Foundation
    Inventors: Thomas D. Eller, Perry V. Halushka, Daniel R. Knapp, Dale Mais
  • Inhibiting platelet aggregation with substituted acetanilides
    Patent number: 4265909
    Abstract: This invention relates to a method for treating mammals to inhibit platelet aggregation which includes administering to mammals a therapeutically effective amount of a compound of the general formula: ##STR1## wherein each of R.sub.1 and R.sub.2 represents a hydrogen atom or a lower alkyl group having from one to three carbon atoms.
    Type: Grant
    Filed: February 6, 1979
    Date of Patent: May 5, 1981
    Inventors: David J. Jollow, Perry V. Halushka