Patents by Inventor Pertti Koski

Pertti Koski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified beta-lactamase and method for its preparation
    Patent number: 7989192
    Abstract: The invention relates to targeted post translational modification of metallo-beta-lactamase by truncation and insertion of a dipeptide at the amino terminal end to reduce amino terminal heterogeneity in a recombinant DNA production system. A protein K-T-E-?BL is expressed, and modified by host proteases to E-?BL. Appropriate nucleotide molecules, vectors and hosts are also described. E-?BL is useful in a pharmaceutical composition for treating antibiotic induced adverse effects in the intestine of patients treated with beta-lactam antibiotics.
    Type: Grant
    Filed: June 19, 2007
    Date of Patent: August 2, 2011
    Assignee: IPSAT Therapies Oy
    Inventors: Susanna Kääriäinen, Nina Wickstrand, Pertti Koski
  • USE OF BETA-LACTAMASE
    Publication number: 20090311234
    Abstract: Class A beta-lactamase may be used for reducing side-effects in the intestine associated with antibiotic therapy with a combination of beta-lactam antibiotic and beta-lactamase inhibitor.
    Type: Application
    Filed: May 28, 2009
    Publication date: December 17, 2009
    Applicant: IPSAT Therapies Oy
    Inventors: Pertti Koski, Tapio Korkolainen, Kristiina Raatesalmi
  • MODIFIED BETA-LACTAMASE AND METHOD FOR ITS PREPARATION
    Publication number: 20090181004
    Abstract: The invention relates to targeted post translational modifi-cation of metallo-beta-lactamase by truncation and inser-tion of a dipeptide at the amino terminal end to reduce amino terminal heterogeneity in a recombinant DNA pro-duction system. A protein K-T-E-?BL is expressed, and modified by host proteases to E-?BL. Appropriate nucleotide molecules, vectors and hosts are also de-scribed. E-?BL is useful in a pharmaceutical composition for treating antibiotic induced adverse effects in the intes-tine of patients treated with beta-lactam antibiotics.
    Type: Application
    Filed: June 19, 2007
    Publication date: July 16, 2009
    Applicant: IPSAT Therapies Oy
    Inventors: Susanna Kaariainen, Nina Wickstrand, Pertti Koski
  • Non-sporulating having parts of the gene encoding sigma G deleted
    Patent number: 7319030
    Abstract: A non-sporulating Bacillus subtilis strain, a method for preparing it and its use as a production organism. A method for preparing a biologically prepared product with the non-sporulating bacterium is also disclosed.
    Type: Grant
    Filed: November 5, 2002
    Date of Patent: January 15, 2008
    Assignee: Ipsat Therapies Oy
    Inventors: Pertti Koski, Susanna Kääriäinen
  • Non-sporulating bacillus subtilis having parts of the gene encoding sigma g deleted
    Publication number: 20050158843
    Abstract: A non-sporulating Bacillus subtilis strain, a method for preparing it and its use as a production organism. A method for preparing a biologically prepared product with the non-sporulating bacterium is also disclosed.
    Type: Application
    Filed: November 5, 2002
    Publication date: July 21, 2005
    Inventors: Pertti Koski, Susanna Kaariainen