Patents by Inventor Pessah YAMPOLSKY

Pessah YAMPOLSKY has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method and kit for assessment of sodium channel-related anti- or pro-arrhythmic potential of compounds
    Patent number: 10254273
    Abstract: The present invention relates to an in vitro method for evaluating the anti- or pro-arrhythmic potential, cardiotoxicity and/or modulation capacity of cardiomyocyte function of compound(s). The present invention also relates to compound(s) identified or evaluated in the method of the invention for use in the treatment of a heart disease. The present invention further relates to the use of the density change of cardiac Nav 1.5 sodium channels in intercalated discs of cardiomyocytes as marker and/or diagnostic for the anti- or pro-arrhythmic potential of a compound, the cardiotoxicity of a compound or modulation capacity of cardiomyocyte function by said compound, and/or in preclinical assessment for cardiac liability of compounds and cardio-safety assessment. The present invention further relates to a kit for evaluating the anti- or pro-arrhythmic potential, cardiotoxicity and/or modulation capacity of cardiomyocyte function of compound(s).
    Type: Grant
    Filed: August 11, 2015
    Date of Patent: April 9, 2019
    Assignee: RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERG
    Inventors: Michael Koenen, Pessah Yampolsky, Patrick A. Schweizer, Dierk Thomas, Hugo A. Katus
  • Method and Kit for Assessment of Sodium channel-Related Anti- or Pro-Arrhythmic Potential of compounds
    Publication number: 20170269064
    Abstract: The present invention relates to an in vitro method for evaluating the anti- or pro-arrhythmic potential, cardiotoxicity and/or modulation capacity of cardiomyocyte function of compound(s). The present invention also relates to compound(s) identified or evaluated in the method of the invention for use in the treatment of a heart disease. The present invention further relates to the use of the density change of cardiac Nav 1.5 sodium channels in intercalated discs of cardiomyocytes as marker and/or diagnostic for the anti- or pro-arrhythmic potential of a compound, the cardiotoxicity of a compound or modulation capacity of cardiomyocyte function by said compound, and/or in preclinical assessment for cardiac liability of compounds and cardio-safety assessment. The present invention further relates to a kit for evaluating the anti- or pro-arrhythmic potential, cardiotoxicity and/or modulation capacity of cardiomyocyte function of compound(s).
    Type: Application
    Filed: August 11, 2015
    Publication date: September 21, 2017
    Inventors: Michael KOENEN, Pessah YAMPOLSKY, Patrick A. SCHWEIZER, Dierk THOMAS, Hugo A. KATUS