Abstract: The present invention relates to combination therapies for treating KRas G12C cancers. In particular, the present invention relates to methods of treating cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a combination of a an agent that blocks Programmed Death-1 receptor (PD-1) and Programmed Death Ligand-1 (PD-L1) signaling and a KRAS G12C inhibitor of Formula (I), Formula I-A or Formula I-B, kits comprising the compositions and methods of use therefor.

Abstract: A computer software license management system wrapper for use in a local computer is described. The software wrapper includes a wrapper interface that provides controlled access to a computer software application file. The software application file is encapsulated by security software code to protect it from unauthorized access. The software wrapper also includes a software license key identifying a license policy specifying a use limitation within a geographic boundary. In addition, the software wrapper includes a license validation mechanism that periodically determines compliance with the license policy. The license validation mechanism permits access by another process operating on the local computer through the wrapper interface in response to a valid license confirmation signal received from the license server. A license server that utilizes and an electronic storefront that sells software license wrappers having software use limitations within a geographic boundary also are described.

Abstract: A computer software license management system wrapper for use in a local computer is described. The software wrapper includes a wrapper interface that provides controlled access to a computer software application file. The software application file is encapsulated by security software code to protect it from unauthorized access. The software wrapper also includes a software license key identifying a license policy specifying a use limitation within a geographic boundary. In addition, the software wrapper includes a license validation mechanism that periodically determines compliance with the license policy. The license validation mechanism permits access by another process operating on the local computer through the wrapper interface in response to a valid license confirmation signal received from the license server. A license server that utilizes and an electronic storefront that sells software license wrappers having software use limitations within a geographic boundary also are described.

Abstract: A computer software license management system wrapper for use in a local computer is described. The software wrapper includes a wrapper interface that provides controlled access to a computer software application file. The software application file is encapsulated by security software code to protect it from unauthorized access. The software wrapper also includes a software license key identifying a license policy specifying a use limitation within a geographic boundary. In addition, the software wrapper includes a license validation mechanism that periodically determines compliance with the license policy. The license validation mechanism permits access by another process operating on the local computer through the wrapper interface in response to a valid license confirmation signal received from the license server. A license server that utilizes and an electronic storefront that sells software license wrappers having software use limitations within a geographic boundary also are described.

Abstract: A computer software license management system wrapper for use in a local computer is described. The software wrapper includes a wrapper interface that provides controlled access to a computer software application file. The software application file is encapsulated by security software code to protect it from unauthorized access. The software wrapper also includes a software license key identifying a license policy specifying a use limitation within a geographic boundary. In addition, the software wrapper includes a license validation mechanism that periodically determines compliance with the license policy. The license validation mechanism permits access by another process operating on the local computer through the wrapper interface in response to a valid license confirmation signal received from the license server. A license server that utilizes and an electronic storefront that sells software license wrappers having software use limitations within a geographic boundary also are described.

Abstract: A computer software license management system wrapper for use in a local computer is described. The software wrapper includes a wrapper interface that provides controlled access to a computer software application file. The software application file is encapsulated by security software code to protect it from unauthorized access. The software wrapper also includes a software license key identifying a license policy specifying a use limitation within a geographic boundary. In addition, the software wrapper includes a license validation mechanism that periodically determines compliance with the license policy. The license validation mechanism permits access by another process operating on the local computer through the wrapper interface in response to a valid license confirmation signal received from the license server. A license server that utilizes and an electronic storefront that sells software license wrappers having software use limitations within a geographic boundary also are described.