Abstract: A system for radio frequency (RF) wire guidance during RF occlusion canalization including a RF wire configured to travel through a blood vessel, an impedance measure unit configured to measure an electrical impedance between the RF wire and a reference electrode, a RF power source, an activation controller configured to connect the RF power source to the RF wire when the impedance measure unit indicates that the RF wire is contacting an occlusion material, a RF wire steering system; and a controller configured to activate the steering system to maintain the RF wire within the occlusion material based on impedance measured by the impedance measure unit.

Abstract: A method of treating an occluded blood vessel includes sensing the impedance at a plurality of locations around the circumference of the blood vessel at least two different frequencies to identify vascular occlusive material, and distinguish vascular occlusive material from the vessel wall.

Abstract: Various systems for advancing medical devices within a subject's body are provided that configured to engage the outer surface of the medical device at a number of points about the circumference of the medical device, to thereby grip the medical device for enabling advancement of the device. The advancing systems include engaging portions configured to engage the outer surface of a medical device at a number of points about the circumference of the medical device. The engaging portions preferably engage opposing sides of the medical device's outer surface over a predetermined longitudinal length, to clamp against a longitudinal portion of the medical device that provides improved surface contact with the medical device over conventional roller guides. Various methods for performing medical procedures utilizing various medical devices and advancer systems are also provided.