Abstract: Disclosed are methods of using a naproxen fill formulation suitable for encapsulation into a soft gel dosage unit to treat inflammation and pain. Methods include administering naproxen to a subject in need thereof to treat pain and inflammation. Methods can include administering naproxen together with another medicament to a subject in need thereof to treat an additional condition such as a cough, cold, allergy, congestion, etc.

Abstract: A controller interface (B12) between a hot water tank controller (B13) and a heat pump controller (B2) in a heating system is provided. The controller interface (B12) comprises a response module configured to receive, from the hot water tank controller (B13), a first signal indicative of a temperature. The response module provides a response signal based on the first signal and a temperature response characteristic and communicates the response signal to the heat pump controller (B2). The controller interface (B12) enables interoperability of a heat pump controller (B2) and a legacy hot water tank system and hot water tank controller (B13).

Abstract: In connection with a data distribution architecture, client-side “deduplication” techniques may be utilized for data transfers occurring among various file system nodes. In some examples, these deduplication techniques involve fingerprinting file system elements that are being shared and transferred, and dividing each file into separate units referred to as “blocks” or “chunks.” These separate units may be used for independently rebuilding a file from local and remote collections, storage locations, or sources. The deduplication techniques may be applied to data transfers to prevent unnecessary data transfers, and to reduce the amount of bandwidth, processing power, and memory used to synchronize and transfer data among the file system nodes. The described deduplication concepts may also be applied for purposes of efficient file replication, data transfers, and file system events occurring within and among networks and file system nodes.

Abstract: A heating system (100), a controller (110) for a heating system and a method of controlling a heating system (100) suitable for responding to grid stress events are disclosed. A heating system (100) comprises a tank (104) for holding water; a heat pump (102) arranged to provide heat to the tank (104); an electric heating element (108) disposed in the tank for heating water; and, a controller (110) configured to: control electric power from an electric power grid to the heat pump (102) and the electric heating element (108); detect a grid stress event; determine a heat pump energy penalty for providing heat in response to the grid stress event under a present operating condition; and, vary, in dependence on the determined heat pump energy penalty, a power provided to the electric heating element (108).

Abstract: A water heating tank is provided comprising a reservoir with a cold water inlet into the reservoir and a hot water outlet from the reservoir. The water heating tank further comprises a heater enclosure located within the reservoir. The heater enclosure encloses at least part of a heater. The heater enclosure has an inlet, a vent and an outlet. The water heating tank further comprises a duct connected to the outlet of the heater enclosure. The duct has an exit located in an upper portion of the reservoir.

Abstract: Systems and method for detecting anomalies in network communication in an industrial automation system. An anomaly detection system, a decentralized system, may identify IoT devices within the network communication and corresponding communication metrics. Using the communication metrics between the identified IoT devise, the anomaly detection system may generate a social network model that is indicative of expected network communication properties. By analyzing social network metrics and the overall entropy of the network communication in real time, the anomaly detection system may identify anomalies that may be associated with potential network vulnerabilities.

Abstract: The composition of anti-TNFR2 antibodies are provided, as well as methods of their preparation and use. This includes methods for treating disorders associated with TNF? and/or TNFR2, such as cancer.

Abstract: The present invention relates to an apparatus and method for making an absorbent structure for an absorbent article, comprising a supporting sheet and thereon an absorbent layer, the absorbent layer comprising an absorbent material. According to the present invention a first moving endless surface is provided which has one or more substantially longitudinally extending first mating strips, and at least one further auxiliary moving endless surface is provided which acts against the first mating strips. Pressure is applied between the first moving endless surface and the auxiliary moving endless surface to the first and second supporting sheets at least within a part of the area of the channels, so as to adhere together the first and second supporting sheets.

Abstract: Various compositions are disclosed for the treatment of viral infections. The compositions of conjugates comprise antibody constructs attached to myeloid cell agonists via a linker are also provided. Additionally provided are the methods of preparation and use of the conjugates. This includes methods for treating viral infections, such as viral liver diseases.

Abstract: Various antibody construct compositions are disclosed. The compositions of antibody construct-immune stimulatory compound conjugates are also provided. Additionally provided are the methods of preparation and used of the antibody construct-immune stimulatory compound conjugates. This includes methods for treating disorders, such as cancer. A genus of STING agonist compounds and method of synthesis is also disclosed.

Abstract: The composition of anti-TNFR2 antibodies are provided, as well as methods of their preparation and use. This includes methods for treating disorders associated with TNF and/or TNFR2, such as cancer.

Abstract: Various compositions are disclosed. The compositions of conjugates comprising immune-modulatory agents are also provided. Additionally provided are the methods of preparation and use of the conjugates. This includes methods for treating disorders, such as cancer and fibrosis.

Abstract: An aspect of the present disclosure relates to a solar humidifier. The solar humidifier includes a solar collector comprises perforations, wherein the solar collector exhibits an absorptance in the range of 0.70 to 0.95 when dry. The solar humidifier also includes a frame on which the solar collector is mounted, wherein the frame provides at least one opening for supplying brine to a surface of the solar collector. The solar humidifier further includes a collection box, wherein the collection box includes an interior volume and is enclosed on a side by the solar collector.

Abstract: The present invention relates to a hot water storage tank (202, 302, 402, 502, 602, 702), defining a primly storage volume (204, 304, 404, 504, 604, 704), with at least one heat source (212, 312, 412, 512, 612, 712) positioned in and operable to directly heat water in the upper portion (207, 307, 407, 507, 607, 707) of the primary storage volume (204, 304, 404, 04, 604, 704), and a pump or other means (237, 337, 437, 537, 637) that draws water, from the lower portion (209, 309, 409, 509, 609, 709) of the tank into a heat transfer device (216, 316, 416, 516, 616, 716), situated in said upper portion (207, 307, 407, 507, 607, 707). The heat transfer device (216, 316, 416, 516, 616, 716) is configured to enable the transfer of heat from heated water in the upper portion (207, 307, 407, 507, 607, 707) to the drawn water prior to discharge into the water in the upper portion (207, 307, 407, 507, 607, 707).

Abstract: Multivalent binding peptides, including bi-specific binding peptides, having immunoglobulin effector function are provided, along with encoding nucleic acids, vectors and host cells as well as methods for making such peptides and methods for using such peptides to treat or prevent a variety of diseases, disorders or conditions, as well as to ameliorate at least one symptom associated with such a disease, disorder or condition.

Abstract: Antibody conjugates of immune-modulatory compounds and pharmaceutical compositions for use in the treatment of disease, such as fibrotic diseases, autoimmune, or autoinflammatory diseases, are disclosed herein. The disclosed conjugates are useful, among other things, in treating fibrotic diseases, autoimmune diseases, or autoinflammatory diseases, such as by modulating TGF?R1, TGF?R2, TNKS, TNIK, or mTOR.

Abstract: Construct-peptide compositions are disclosed. Construct-peptide compositions conjugated to immune stimulatory compounds are also provided. Additionally provided are the methods of preparation and use of the construct-peptide compositions and construct-peptide compositions conjugated to immune stimulatory compound. This includes methods for treating disorders, such as cancer.

Abstract: Methods and conjugates are disclosed for alleviating toxicity(ies) associated with administration of immune-stimulatory conjugates, and in particular for alleviating toxicity(ies) associated with intravenous administration of such conjugates.

Abstract: An aspect of the present disclosure relates to a solar humidifier. The solar humidifier includes a solar collector comprises perforations, wherein the solar collector exhibits an absorptance in the range of 0.70 to 0.95 when dry. The solar humidifier also includes a frame on which the solar collector is mounted, wherein the frame provides at least one opening for supplying brine to a surface of the solar collector. The solar humidifier further includes a collection box, wherein the collection box includes an interior volume and is enclosed on a side by the solar collector.

Abstract: An absorbent core for disposable absorbent articles comprising absorbent material having a basis weight that varies across the absorbent core is provided.