Abstract: Compounds of formula (I): wherein variable groups are as defined within; for use in the inhibition of 11?HSD1 are described.

Abstract: A method for inhibiting 11?HSD1 by administering a compound of formula (I) is described, wherein A, X, Y, R1, R12, n, q, and m are as described in the specification. Novel compounds and methods employing them are also described and claimed.

Abstract: An interface and method for determining an operational reliability factor SB for a drive, including gear unit and motor, provided for a load, an operational reliability factor SB being determined for the drive or its gear unit from a load collective that is at least three-dimensional.

Abstract: An oral hygiene composition comprises a cationic antimicrobial agent (such as chlorhexidine gluconate), an anionic active agent (such as an alkali metal pyrophosphate) and both a non-ionic surfactant having a high hydrophilic/lipophilic balance (such as an ethoxylated castor oil) and an amphoteric surfactant (such as cocoamidopropyl betaine).

Abstract: In a plastic pipe joining system a plastic sleeve is provided to extend on both sides beyond the region of contact or closest approach to one another of pipes to be joined with the sleeve being fused to both pipes, the sleeve heated to Curie temperature of high mu material excited by an externally generated high frequency magnetic field. The heater may be embedded in the sleeve and the sleeve may also be employed with end caps that extended over the sleeve, the end caps and sleeve being fused to one another and the pipes by heaters carried by the end caps or the sleeve. An external heater may also be employed which in conjuction with shaped end members provides the sleeve with beveled or tapered edges to enhance the ability of the sleeve to withstand cracking.

Abstract: A tube joint has a pair of tubes extending in different directions and connecting means for disposition between the tubes to connect them together. The connecting means has a pair of parts adapted to be juxtaposed so that a pair of spigot portions respectively on the parts from a spigot formation for fitting closely within one of the tubes extending in one direction. Abutment means on the parts limits insertion of the spigot formation into the tube and a lateral projection is provided on at least one of the parts to enable the other of the tubes to be secured thereto so as to extend in a different direction.

Abstract: A document handling apparatus by which documents are engaged and conveyed is disclosed. The apparatus includes a document-transport belt for engaging a document on a document-receiving surface and means for driving the belt to convey a said document across the surface. A document hitch supports the document intermediate document engaging zones thereof spaced apart in the direction of travel of the belt. The hitch comprises a base portion defining a surface supporting the belt and sidewalls for guiding the belt, the base portion having a transversely extending channel in the belt-support surface defining at least one cleaning edge for cleaning the surface of the belt passing thereover.

Abstract: A sheet handling apparatus in which sheets are automatically moved in sequence into a registered position on a work surface and then moved out of that position to make way for the next sheet is disclosed. The sheet handling apparatus includes a sheet transport for conveying a sheet over a receiving surface and including a drive surface engageable with a sheet on the surface, and a spring supported roller and stop arrangement for automatically varying the frictional engagement between the drive surface and a sheet on the receiving surface.

Abstract: The invention is concerned with structures and with means for joining tubes together to form such structures. A connecting means has a pair of component parts each of which has spigot portions extending oppositely from a boss, the portions being such that a complete connecting means has oppositely extending spigots for insertion into respective tubes. Each component has in its boss a locking means for interaction with corresponding means on another component with which it is assembled to provide resistance to withdrawal of the spigots from the tubes.