Abstract: Compounds that inhibit KRas G12D. In particular, compounds that inhibit the activity of KRas G12D, pharmaceutical compositions comprising the compounds and methods of use therefor, and in particular, methods of treating cancer. The compounds have a general structure represented by Formula (I): or a pharmaceutically acceptable salt thereof.

Abstract: A method of making an article 2 comprising an ultra-thin sheet 26 of material secured at lateral regions to a support member, the method comprises laying the ultra-thin sheet on a substrate 20, forming the support member on the lateral regions of the ultra-thin sheet such that the lateral regions of the ultra-thin sheet are sandwiched between the support member and the substrate and adhered to the support member, and removing the substrate by vaporisation or by a dissolution step using a solvent, to leave the article. The ultra-thin sheet is supported around its periphery and has a central region in which the ultra-thin sheet is free from contact with any other material.

Abstract: A multi-mode cavity filter, comprising: a dielectric resonator body incorporating a piece of dielectric material, the piece of dielectric material having a shape such that it can support at least a first resonant mode and a second substantially degenerate resonant mode; a conductive layer substantially covering the dielectric resonator body but having one or more apertures therein allowing access to the dielectric resonator body; and a coupling structure arranged in an aperture of the one or more apertures, comprising at least one coupling path for at least one of coupling an input signal to the first and second resonant modes and coupling an output signal from the first and second resonant modes, the coupling path having an open-circuit end located adjacent to an edge of the aperture for controlling a strength of electric field generated by the coupling structure.

Abstract: A method of making an article 2 comprising an ultra-thin sheet 26 of material secured at lateral regions to a support member, the method comprises laying the ultra-thin sheet on a substrate 20, forming the support member on the lateral regions of the ultra-thin sheet such that the lateral regions of the ultra-thin sheet are sandwiched between the support member and the substrate and adhered to the support member, and removing the substrate by vaporisation or by a dissolution step using a solvent, to leave the article. The ultra-thin sheet is supported around its periphery and has a central region in which the ultra-thin sheet is free from contact with any other material.

Abstract: A system, method, apparatus, means, and computer program code that facilitate communication between trustees, investors, borrowers, and other vendors associated with a commercial mortgage loan.

Abstract: A system, method, apparatus, means, and computer program code that facilitate communication between trustees, investors, borrowers, and other vendors associated with a commercial mortgage loan.

Abstract: A cooking whip for mixing foods is disclosed. The cooking whip includes an elongate tubular handle portion. A whip portion has a head and a plurality of resiliently deformable loops extending from the head. The whip portion is detachably coupled to the lower end of the handle portion. An elongate shaft portion with opposite first and second ends and a longitudinal axis extending between the ends is removably insertable in the handle portion. The first end of the shaft portion is coupled to the head of the whip portion.