Patents by Inventor Peter A. Chiarelli

Peter A. Chiarelli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IRON OXIDE NANOPARTICLE FOR SUPPRESSING DRUG-RESISTANT GENE FOR THE TREATMENT OF GLIOBLASTOMA
    Publication number: 20230405145
    Abstract: A nanoparticle for targeted siRNA delivery comprising an iron oxide core and a chitosan-polyethylene glycol-polyethylenimine copolymer coating surrounding the core, chlorotoxin covalently coupled to the coating, and an siRNA reversibly associated to the coating by non-covalent interaction. Methods for making the nanoparticle and methods for using the nanoparticle to suppress the expression of O6-methylguanine-DNA methyltransferase (MGMT), treating brain cancer, and killing cancer stem cells.
    Type: Application
    Filed: October 6, 2021
    Publication date: December 21, 2023
    Applicant: University of Washington
    Inventors: Miqin Zhang, Richard G. Ellenbogen, Kui Wang, Forrest M. Kievit, John R. Silber, Zachary Stephen, Peter A. Chiarelli
  • OXYGEN REACTIVE POLYMERS FOR TREATMENT OF TRAUMATIC BRAIN INJURY
    Publication number: 20220152091
    Abstract: Methods and compositions for treating traumatic brain injury. The methods and compositions utilize a multi-functional oxygen reactive polymer (ORP) that includes repeating units that include a reactive oxygen species (ROS) scavenging group and a polyalkylene oxide group. For theranostic applications, the oxygen reactive polymer further includes a diagnostic group.
    Type: Application
    Filed: July 19, 2021
    Publication date: May 19, 2022
    Applicant: University of Washington
    Inventors: Patrick S. Stayton, Menko P. Ypma, Peter A. Chiarelli, Joshua Sang Hun Park, Richard G. Ellenbogen, Julia Mengyun Xu, Pierre D. Mourad, Donghoon Lee, Anthony Convertine, Forrest M. Kievit
  • Oxygen reactive polymers for treatment of traumatic brain injury
    Patent number: 11065272
    Abstract: Methods and compositions for treating traumatic brain injury. The methods and compositions utilize a multi-functional oxygen reactive polymer (ORP) that includes repeating units that include a reactive oxygen species (ROS) scavenging group and a polyalkylene oxide group. For theranostic applications, the oxygen reactive polymer further includes a diagnostic group.
    Type: Grant
    Filed: October 6, 2016
    Date of Patent: July 20, 2021
    Assignee: University of Washington
    Inventors: Patrick S. Stayton, Menko P. Ypma, Peter A. Chiarelli, Joshua Sang Hun Park, Richard G. Ellenbogen, Julia Mengyun Xu, Pierre D. Mourad, Donghoon Lee, Anthony Convertine, Forrest M. Kievit
  • OXYGEN REACTIVE POLYMERS FOR TREATMENT OF TRAUMATIC BRAIN INJURY
    Publication number: 20180289736
    Abstract: Methods and compositions for treating traumatic brain injury. The methods and compositions utilize a multi-functional oxygen reactive polymer (ORP) that includes repeating units that include a reactive oxygen species (ROS) scavenging group and a polyalkylene oxide group. For theranostic applications, the oxygen reactive polymer further includes a diagnostic group.
    Type: Application
    Filed: October 6, 2016
    Publication date: October 11, 2018
    Applicant: University of Washington
    Inventors: Patrick S. Stayton, Menko R. Ypma, Peter A. Chiarelli, Joshua Sang Hun Park, Richard G. Ellenbogen, Julia Mengyun Xu, Pierre D. Mourad, Donghoon Lee, Anthony Convertine, Forrest M. Kievit
  • Fabrication of multilayered thin films via spin-assembly
    Patent number: 7179679
    Abstract: An process of forming multilayer thin film heterostructures is disclosed and includes applying a solution including a first water-soluble polymer from the group of polyanionic species, polycationic species and uncharged polymer species onto a substrate to form a first coating layer on the substrate, drying the first coating layer on the substrate, applying a solution including a second water-soluble polymer from the group of polyanionic species, polycationic species and uncharged polymer species onto the substrate having the first coating layer to form a second coating layer on the first coating layer wherein the second water-soluble polymer is of a different material than the first water-soluble polymer, and drying the second coating layer on the first coating layer so as to form a bilayer structure on the substrate.
    Type: Grant
    Filed: July 11, 2003
    Date of Patent: February 20, 2007
    Assignee: The Regents of the University of California
    Inventors: Peter A. Chiarelli, Jeanne M. Robinson, Joanna L. Casson, Malkiat S. Johal, Hsing-Lin Wang
  • Fabrication of multilayered thin films via spin-assembly
    Publication number: 20040086649
    Abstract: An process of forming multilayer thin film heterostructures is disclosed and includes applying a solution including a first water-soluble polymer from the group of polyanionic species, polycationic species and uncharged polymer species onto a substrate to form a first coating layer on the substrate, drying the first coating layer on the substrate, applying a solution including a second water-soluble polymer from the group of polyanionic species, polycationic species and uncharged polymer species onto the substrate having the first coating layer to form a second coating layer on the first coating layer wherein the second water-soluble polymer is of a different material than the first water-soluble polymer, and drying the second coating layer on the first coating layer so as to form a bilayer structure on the substrate.
    Type: Application
    Filed: July 11, 2003
    Publication date: May 6, 2004
    Inventors: Peter A. Chiarelli, Jeanne M. Robinson, Joanna L. Casson, Malkiat S. Johal, Hsing-Lin Wang