Abstract: Methods of changing transcriptional output of chromatin are described. The method includes altering interaction of the chromatin with a chromatin-associated RNA at each of a plurality of different sites of the chromatin. The chromatin-associated RNA at each different site interacts with the chromatin at that site and regulates transcription and/or post-transcriptional modification of a transcript encoded by a transcribed region of the chromatin. Altering the interaction of the chromatin with the chromatin-associated RNA causes a change in level of transcription and/or post-transcriptional modification of a transcript encoded by the transcribed region. Compositions and kits for changing transcriptional output of chromatin are also described.

Abstract: The disclosure provides for structured illumination microscopy (SIM) imaging systems. In one set of implementations, a SIM imaging system may be implemented as a multi-arm SIM imaging system, whereby each arm of the system includes a light emitter and a beam splitter (e.g., a transmissive diffraction grating) having a specific, fixed orientation with respect to the system's optical axis. In a second set of implementations, a SIM imaging system may be implemented as a multiple beam splitter slide SIM imaging system, where one linear motion stage is mounted with multiple beam splitters having a corresponding, fixed orientation with respect to the system's optical axis. In a third set of implementations, a SIM imaging system may be implemented as a pattern angle spatial selection SIM imaging system, whereby a fixed two-dimensional diffraction grating is used in combination with a spatial filter wheel to project one-dimensional fringe patterns on a sample.

Abstract: For wellbore operations, a pipe handler moves pipe up to a rig floor. A pipe loader moves pipe from a presented position into alignment with well center. The pipe handler moves pipe up to a slanted presented position. The slanted presented position can be adjusted by manipulating the drive system.

Abstract: Methods of forming an article from a molten plastic composition comprising a polymer and a blowing agent. The methods include injecting the molten plastic composition into a mould, allowing the plastic composition to form a first solid skin adjacent to an in contact with a first cavity-forming surface of the mould and a second solid skin adjacent to and in contact with a second cavity-forming surface of the mould, and then opening the mould before the molten plastic composition between the first and second solid skins in at least one portion of the circumference of a region of the mould cavity defining an annular cross-section of the cavity has solidified.

Abstract: Methods of forming an article from a molten plastic composition comprising a polymer and a blowing agent. The methods include injecting the molten plastic composition into a mould, allowing the plastic composition to form a first solid skin adjacent to an in contact with a first cavity-forming surface of the mould and a second solid skin adjacent to and in contact with a second cavity-forming surface of the mould, and then opening the mould before the molten plastic composition between the first and second solid skins in at least one portion of the circumference of a region of the mould cavity defining an annular cross-section of the cavity has solidified.

Abstract: A slips positioning apparatus for a wellhead installation is installed in a fixed position relative to the blow out preventer and allows releasable locking of the slips relative to well center and driving movement of the slips relative to well center. The slips positioning apparatus includes a slips-mounting structure for accepting connection of the slips; an installation structure for mounting the apparatus rigidly above the blow out preventer and relative to well center. The installation structure is a plate that defines a first plane. The apparatus further includes a first and a second linear guides configured for movement of the slips-mounting structure relative to the installation structure along respective first and second directions in planes substantially parallel with the first plane; and first and second linear actuators for moving the slips-mounting structure respectively along the first and second linear guides.

Abstract: An optical cleaning cartridge for automated cleaning of optical components of analysis instruments is disclosed.

Abstract: For wellbore operations, a pipe handler moves pipe up to a rig floor. A pipe loader moves pipe from a presented position into alignment with well center. The pipe handler moves pipe up to a slanted presented position. The slanted presented position can be adjusted by manipulating the drive system.

Abstract: A rotor system for aerial vehicles where two or more rotor systems are used in a coaxial or tandem arrangement on the aerial vehicle.

Abstract: A system includes a plurality of modular subassemblies and a plate; wherein each modular subassembly comprises an enclosure and a plurality of optical components aligned to the enclosure, and each enclosure comprises a plurality of mounting structures; and wherein each modular subassembly is mechanically coupled to the plate by attachment of a mounting structure of the modular subassembly directly to a corresponding mounting structure located on the plate, such that by mechanically coupling each modular subassembly to the plate using the mounting structure of the modular subassembly and the corresponding mounting structure on the plate, adjacent modular subassemblies are aligned to each other upon such attachment, and wherein two of the modular subassemblies mechanically coupled to the plate are also attached to each other by mechanically coupling an alignment structure on one of the two modular subassemblies to a respective alignment structure on the other of the two modular subassemblies.

Abstract: Imaging systems including an objective lens and a line generation module are described herein. The objective lens may focus a first light beam emitted by the line generation module and a second light beam emitted by the line generation module at a focal point external to a sample so as to adjust line width. Line width may be increased to lower overall power density of a light beam on a surface of the sample such that the power density of the light beam on the surface of the sample is below a photosaturation threshold of a dye on the sample.

Abstract: The concepts relate to data handling, and more specifically to data handling scenarios where data is revised on one computer and stored on another computer. One example can obtain a set of blobs relating to revisions of a file. The example can determine a target size of datastore blobs. In an instance where a total size of the set of blobs is less than the target size, this example can aggregate the set of blobs into an individual datastore blob. Otherwise, the example can identify new or edited individual blobs of the set and aggregate the new or edited individual blobs into first datastore blobs. The example can also aggregate other individual blobs of the set into second datastore blobs.

Abstract: For wellbore operations, a pipe handler moves pipe up to a rig floor. A pipe loader moves pipe from a presented position into alignment with well center. The pipe handler moves pipe up to a slanted presented position. The slanted presented position can be adjusted by manipulating the drive system.

Abstract: A system for biological sample analysis includes a plurality of modular subassemblies and a precision mounting plate, wherein each modular subassembly includes an enclosure and a plurality of optical components pre-aligned to the enclosure, and the enclosure includes a plurality of precision mounting structures, and each modular subassembly is mechanically coupled to the precision mounting plate, such that each precision mounting structure from a modular subassembly attaches directly to a corresponding precision mounting structure located on the precision mounting plate or an adjacent modular subassembly to optimize optomechanical tolerance.

Abstract: The disclosure provides for structured illumination microscopy (SIM) imaging systems. In one set of implementations, a SIM imaging system may be implemented as a multi-arm SIM imaging system, whereby each arm of the system includes a light emitter and a beam splitter (e.g., a transmissive diffraction grating) having a specific, fixed orientation with respect to the system's optical axis. In a second set of implementations, a SIM imaging system may be implemented as a multiple beam splitter slide SIM imaging system, where one linear motion stage is mounted with multiple beam splitters having a corresponding, fixed orientation with respect to the system's optical axis. In a third set of implementations, a SIM imaging system may be implemented as a pattern angle spatial selection SIM imaging system, whereby a fixed two-dimensional diffraction grating is used in combination with a spatial filter wheel to project one-dimensional fringe patterns on a sample.

Abstract: The disclosure provides for structured illumination microscopy (SIM) imaging systems. In one set of implementations, a SIM imaging system may be implemented as a multi-arm SIM imaging system, whereby each arm of the system includes a light emitter and a beam splitter (e.g., a transmissive diffraction grating) having a specific, fixed orientation with respect to the system's optical axis. In a second set of implementations, a SIM imaging system may be implemented as a multiple beam splitter slide SIM imaging system, where one linear motion stage is mounted with multiple beam splitters having a corresponding, fixed orientation with respect to the system's optical axis. In a third set of implementations, a SIM imaging system may be implemented as a pattern angle spatial selection SIM imaging system, whereby a fixed two-dimensional diffraction grating is used in combination with a spatial filter wheel to project one-dimensional fringe patterns on a sample.

Abstract: A tool carrier, which is also known as a top drive or a power swivel, for a well operation rig includes link arms coupled between the rotating hook assembly and the lower pipe gripping structure, the link arms each secured to the rotating hook assembly by a first rigid connection and secured to the lower pipe gripping structure by a second rigid connection such that the link arms can extend along well center even when operating in slant. Another tool carrier includes a hinge between the mast and the main housing. The hinge permits the tool carrier to be moved into a more central position when folded onto the rig chassis for transport.