Patents by Inventor Peter A. Clausen

Peter A. Clausen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of detecting a plurality of sequence specific DNA binding proteins with oligonucleotide detection duplexes
    Patent number: 7771940
    Abstract: Compositions and methods are provided for detecting and measuring DNA-binding proteins. The compositions and methods permit the simultaneous or near-simultaneous detection of multiple DNA-binding proteins in a multiplex or array format, and can be used to generate profiles of DNA binding activity by proteins, specifically, transcription factors. Multiple protein-DNA binding events in a single sample may be detected and quantitated in a high-throughput format.
    Type: Grant
    Filed: October 16, 2006
    Date of Patent: August 10, 2010
    Assignee: Marligen Biosciences, Inc.
    Inventors: Peter A. Clausen, David P. Carlson, James G. Lazar
  • Methods of detecting sequence-specific DNA binding proteins
    Publication number: 20090208927
    Abstract: Compositions and methods are provided for detecting and measuring DNA-binding proteins. The compositions and methods permit the simultaneous or near-simultaneous detection of multiple DNA-binding proteins in a multiplex or array format, and can be used to generate profiles of DNA binding activity by proteins, specifically, transcription factors. Multiple protein-DNA binding events in a single sample may be detected and quantitated in a high-throughput, format.
    Type: Application
    Filed: October 16, 2006
    Publication date: August 20, 2009
    Applicant: Marligen Biosciences, Inc.
    Inventors: Peter A. Clausen, David P. Carlson, James G. Lazar
  • Multiplex method of detecting sequence-specific DNA binding proteins using detection duplexes comprising unmodified nucleic acid sequences as capture tags
    Patent number: 7122317
    Abstract: Compositions and methods are provided for detecting and measuring DNA-binding proteins. The compositions and methods permit the simultaneous or near-simultaneous detection of multiple DNA-binding proteins in a multiplex or array format, and can be used to generate profiles of DNA binding activity by proteins, specifically, transcription factors. Multiple protein-DNA binding events in a single sample may be detected and quantitated in a high-throughput format.
    Type: Grant
    Filed: March 28, 2003
    Date of Patent: October 17, 2006
    Assignee: Marligen Biosciences, Inc.
    Inventors: Peter A. Clausen, David P. Carlson, James G. Lazar
  • Detection of DNA-binding proteins
    Publication number: 20030215854
    Abstract: Compositions and methods are provided for detecting and measuring DNA-binding proteins. The compositions and methods permit the simultaneous or near-simultaneous detection of multiple DNA-binding proteins in a multiplex or array format, and can be used to generate profiles of DNA binding activity by proteins, specifically, transcription factors. Multiple protein-DNA binding events in a single sample may be detected and quantitated in a high-throughput format.
    Type: Application
    Filed: March 28, 2003
    Publication date: November 20, 2003
    Inventors: Peter A. Clausen, David P. Carlson, James G. Lazar
  • Methods and compositions for DRM, a secreted protein with cell growth inhibiting activity
    Publication number: 20030078406
    Abstract: The present invention provides an isolated nucleic acid encoding DRM protein, an isolated DRM polypeptide, and a fusion polypeptide comprising a DRM protein and a green fluorescent protein. The present invention also provides a method of arresting the growth of a cell, comprising administering to the cell an effective amount of DRM protein or an active fragment thereof; a method of inhibiting tumor cell growth, comprising administering to a tumor cell an effective amount of DRM protein or an active fragment thereof; and a method of treating a hyperproliferative cell disorder in a subject diagnosed with a hyperproliferative cell disorder, comprising administering to the subject an effective amount of DRM protein or an active fragment thereof, in a pharmaceutically acceptable carrier.
    Type: Application
    Filed: December 27, 2001
    Publication date: April 24, 2003
    Applicant: The Government of the U.S.A., as represented by the Secretary, Dept. of Health & Human Services
    Inventors: Donald G. Blair, Peter A. Clausen, Lilia Z. Topol, Maria Marx, Georges Calothy