Abstract: A computer-implemented method for designing a sheet part comprising beads. The method comprises providing a CAD model representing the part. The CAD model includes a feature tree. The feature tree has one or more CAD parameters each having an initial value. The method further comprises providing a bead optimization program specified by one or more use and/or manufacturing performance indicators. The one or more indicators comprise one or more objective function(s) and/or one or more constraints. The method further comprises modifying the initial values of the one or more CAD parameters by solving the optimization program using a gradient-based bead optimization method. The optimization method has as free variables the one or more CAD parameters. The optimization method uses sensitivities. Each sensitivity is an approximation of a respective derivative of a respective performance indicator with respect to a respective CAD parameter.

Abstract: A computer-implemented method for designing a manufacturing product. The method includes obtaining a CAD model representing the manufacturing product. The CAD model includes a feature tree. The feature tree has one or more CAD parameters each having an initial value. The method also includes obtaining an optimization program. The optimization program is specified by one or more use and/or manufacturing performance indicators. The one or more indicators having one or more objective functions and/or one or more constraints. The method further includes modifying the initial values of the one or more CAD parameters by solving the optimization program using a gradient-based optimization method. The optimization method has as free variable the one or more CAD parameters and uses sensitivities. Each sensitivity is an approximation of a respective derivative of a respective performance indicator with respect to a respective CAD parameter.

Abstract: A method for processing client information by a first client, the client information having a plurality of client data values for matching a first and a second client, the method providing a client matching application comprising: providing a request to a second client to transmit client information to a first client if not already transmitted, step 410; determining, by the first client, a client operation, based on the client information containing client data including predetermined parameters for client matching, that is compatible with the client devices step 420; and performing one or more client based processing operations including synchronization and transmission of client information based to provide the matching application of a first and a second client within a predetermined distance of the clients. The invention also relates to a device, a computer program product, and a system.

Abstract: Compositions and methods are provided for detecting and measuring DNA-binding proteins. The compositions and methods permit the simultaneous or near-simultaneous detection of multiple DNA-binding proteins in a multiplex or array format, and can be used to generate profiles of DNA binding activity by proteins, specifically, transcription factors. Multiple protein-DNA binding events in a single sample may be detected and quantitated in a high-throughput format.

Abstract: Compositions and methods are provided for detecting and measuring DNA-binding proteins. The compositions and methods permit the simultaneous or near-simultaneous detection of multiple DNA-binding proteins in a multiplex or array format, and can be used to generate profiles of DNA binding activity by proteins, specifically, transcription factors. Multiple protein-DNA binding events in a single sample may be detected and quantitated in a high-throughput, format.

Abstract: Compositions and methods are provided for detecting and measuring DNA-binding proteins. The compositions and methods permit the simultaneous or near-simultaneous detection of multiple DNA-binding proteins in a multiplex or array format, and can be used to generate profiles of DNA binding activity by proteins, specifically, transcription factors. Multiple protein-DNA binding events in a single sample may be detected and quantitated in a high-throughput format.

Abstract: This invention provides novel high density memory devices that are electrically addressable permitting effective reading and writing, that provide a high memory density (e.g., 1015 bits/cm3), that provide a high degree of fault tolerance, and that are amenable to efficient chemical synthesis and chip fabrication. The devices are intrinsically latchable, defect tolerant, and support destructive or non-destructive read cycles. In a preferred embodiment, the device comprises a fixed electrode electrically coupled to a storage medium having a multiplicity of different and distinguishable oxidation states wherein data is stored in said oxidation states by the addition or withdrawal of one or more electrons from said storage medium via the electrically coupled electrode.

Abstract: Methods and compositions for the detection of biomolecules, for example, proteases, are provided. The novel compositions, methods, and kits of the present invention have broad applicability in the detection of proteases, and providing enhanced specificity in the detection of proteases. The compositions and methods may be used to measure the activities of multiple proteases simultaneously or in a multiplexed format, particularly in planar and liquid array formats.

Abstract: A fluid supply unit (1), in particular a hydraulic supply unit is disclosed, comprising a pressure generator (2) for the fluid, in particular a pump or hydraulic fluids and a pressure outlet (7). The aim of the invention is to broaden the application possibilites of such a unit. Said aim is achieved, whereby a pressure amplifier (6) is arranged between the pressure generator (2) and the pressure outlet (7) which is mechanically fixed to the pressure generator (2).

Abstract: A hydraulic tool has a motor, a valve, a hydraulic intensifier and a supply connector. The hydraulic intensifier is arranged between the valve and the motor. The valve and the motor are arranged behind one another in a longitudinal direction of the tool. The hydraulic intensifier has at least one intensifier piston having a movement direction that is positioned at a first angle greater than 0° relative to the longitudinal direction of the tool.

Abstract: A fiber dispensing apparatus includes a hopper containing a plurality of fibers. A conveyor device having a plurality of flights thereon is provided at a bottom portion of the hopper. The conveyor device operates to move the fibers from the hopper into a fan-powered injector, which separates the fibers into an air stream and blows the separated fibers through a pipe system to a transit mixer.

Abstract: Compositions and methods are provided for detecting and measuring DNA-binding proteins. The compositions and methods permit the simultaneous or near-simultaneous detection of multiple DNA-binding proteins in a multiplex or array format, and can be used to generate profiles of DNA binding activity by proteins, specifically, transcription factors. Multiple protein-DNA binding events in a single sample may be detected and quantitated in a high-throughput format.

Abstract: The present invention provides an isolated nucleic acid encoding DRM protein, an isolated DRM polypeptide, and a fusion polypeptide comprising a DRM protein and a green fluorescent protein. The present invention also provides a method of arresting the growth of a cell, comprising administering to the cell an effective amount of DRM protein or an active fragment thereof; a method of inhibiting tumor cell growth, comprising administering to a tumor cell an effective amount of DRM protein or an active fragment thereof; and a method of treating a hyperproliferative cell disorder in a subject diagnosed with a hyperproliferative cell disorder, comprising administering to the subject an effective amount of DRM protein or an active fragment thereof, in a pharmaceutically acceptable carrier.

Abstract: The present invention relates generally to compositions, methods and kits for use in extracting and isolating protein or peptide molecules. More specifically, the invention relates to such compositions, methods and kits that are useful in the isolation of protein or peptide molecules from cells (e.g., bacterial cells, animal cells, fungal cells, viruses, yeast cells or plant cells) via lysis and one or more additional isolation procedures, such as one or more filtration and/or chromatography procedures. In particular, the invention relates to compositions, methods and kits wherein protein or peptide molecules are isolated using an integrated lysis/filtration matrix, which may comprise one or more supports (e.g., polyolefin, scintered polyethylene, nitrocellulose, polypropylene, polycarbonate, cellulose acetate, silica, and the like). The compositions, methods and kits of the invention are suitable for isolating a variety of forms of protein or peptide molecules from cells.