Patents by Inventor Peter A. Crooks

Peter A. Crooks has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20030172404
    Abstract: This invention provides a method for modifying plant growth and development comprising expressing an isolated nucleic acid sequence encoding Cdc25 or a homologue, analogue or derivative thereof in one or more plant cells, tissues or organs operably under the control of a regulatable promoter that does not confer expression throughout the plant under all conditions.
    Type: Application
    Filed: April 10, 2002
    Publication date: September 11, 2003
    Inventors: Peter Crook Lloyd John, Kerong Zhang, Francis John Sek, Wim Van Camp
  • Publication number: 20030125345
    Abstract: The present invention generally relates to nicotinic compounds, in the form of aryl substituted olefinic compounds, as well as pro-drug, N-oxide, metabolite and pharmaceutically acceptable salt forms thereof. Methods of modulating neurotransmitter release via administration of the compounds, pro-drugs, N-oxides and/or pharmaceutically acceptable salts are also disclosed.
    Type: Application
    Filed: October 2, 2002
    Publication date: July 3, 2003
    Inventors: William S. Caldwell, Gary M. Dull, Balwinder S. Bhatti, Srishailkumar B. Hadimani, Haeil Park, Jared M. Wagner, Peter A. Crooks, Patrick M. Lippiello, Merouane Bencherif
  • Publication number: 20030100547
    Abstract: Cis-2,6-disubstituted piperdine analogs, or lobeline analogs, having the general formula: 1
    Type: Application
    Filed: August 30, 2002
    Publication date: May 29, 2003
    Applicant: University of Kentucky Research Foundation
    Inventors: Linda P. Dwoskin, Peter A. Crooks, Marlon D. Jones
  • Patent number: 6503922
    Abstract: Pharmaceutical compounds comprising bridged nicotine analogs of N-octylnicotinium iodide (NONI) having selective antagonist properties at &agr;3&bgr;2-containing nicotinic receptor subtypes, and compositions containing these compounds. The compounds and compositions are used to treat central nervous system pathologies.
    Type: Grant
    Filed: August 30, 2001
    Date of Patent: January 7, 2003
    Assignee: University of Kentucky Research Foundation
    Inventors: Peter A. Crooks, Linda P. Dwoskin, Rui Xu, Vladimir P. Grinevich
  • Patent number: 6455543
    Abstract: Cis-2,6-disubstituted piperdine analogs, or lobeline analogs, having the general formula: are used to treat diseases of the central nervous system, drug abuse and withdrawal therefrom as well as to treating eating disorders.
    Type: Grant
    Filed: July 28, 2000
    Date of Patent: September 24, 2002
    Assignee: University of Kentucky Research Foundation
    Inventors: Linda P. Dwoskin, Peter A. Crooks, Marlon D. Jones
  • Publication number: 20020099069
    Abstract: Pharmaceutical compounds comprising bridged nicotine analogs of N-octylnicotinium iodide (NONI) having selective antagonist properties at &agr;3&bgr;2-containing nicotinic receptor subtypes, and compositions containing these compounds. The compounds and compositions are used to treat central nervous system pathologies.
    Type: Application
    Filed: August 30, 2001
    Publication date: July 25, 2002
    Inventors: Peter A. Crooks, Linda P. Dwoskin, Rui Xu, Vladimir P. Grinevich
  • Patent number: 6403602
    Abstract: 3-O-Acetylmorphine-6-sulfate analogues are potent, centrally-acting morphine derivatives. The compounds are useful for the treatment of pain.
    Type: Grant
    Filed: December 31, 1997
    Date of Patent: June 11, 2002
    Assignee: The University of Kentucky Research Foundation
    Inventors: Peter A. Crooks, Abdulghani A. Houdi, Santosh G. Kottayil, D. Allen Butterfield
  • Publication number: 20020065323
    Abstract: Pharmaceutical preparations containing of agmatine, congeners, analogs or derivatives thereof for use in preventing or treating epilepsy, seizures and other electroconvulsive disorders are provided. Embodiments include administering an effective amount of agmatine, an agmatine analog or a pharmaceutically acceptable salt thereof to a human subject in need of treatment or prevention of epilepsy, seizure or other electroconvulsive disorder to treat, reduce, or prevent the disorder in the subject.
    Type: Application
    Filed: June 15, 2001
    Publication date: May 30, 2002
    Inventors: Peter A. Crooks, Aimee K. Bence, David R. Worthen
  • Patent number: 6218434
    Abstract: Nigella sativa derivatives, thymoquinone (TM) and dithymoquinone (DIM) are used in treatment of parental and multi-drug resistant human cancers.
    Type: Grant
    Filed: May 28, 1999
    Date of Patent: April 17, 2001
    Assignee: University of Kentucky Research Foundation
    Inventors: Peter A. Crooks, David R. Worthen, Omar A. Ghosheh
  • Patent number: 6105932
    Abstract: A radiator valve for preventing water from leaking out of a radiator when the radiator is detached from its hot water supply. The radiator valve includes a tubular housing with a lumen and opposite first and second ends. A ball valve is rotatably mounted in the lumen of the tubular housing to substantially block passage of fluid through the lumen of the tubular housing. The first end of the tubular housing is designed for attachment to a fluid opening of a radiator to fluidly connect the lumen of the tubular housing to the fluid housing of the radiator. The second end of the tubular housing is designed for removable attachment to a fluid supply outlet of a fluid supply conduit to fluidly connect the lumen of the housing to the fluid supply conduit.
    Type: Grant
    Filed: October 22, 1998
    Date of Patent: August 22, 2000
    Inventor: Peter Crook
  • Patent number: 6087175
    Abstract: The present invention is directed to a method for controlling plant cell growth comprising modulating the level and or catalytic activity of a cell cycle control protein in a plant cell for a time and under conditions sufficient to control cell division. Preferably, the cell cycle control protein is p34.sup.cdc2 or p34.sup.cdc2 -like molecule having a cyclin related kinase function and the plant is a monocotyledonous plant or dicotyledonous plant. The present invention is also directed to other cell cycle control proteins, so termed since they function similarly to p34.sup.cdc2 or control p34.sup.cdc2 activity. Such proteins include p13.sup.suc1, cyclin, cdc25, and the products of nim1, wee1 and mik-1 or combinations thereof, separately, or together with p34.sup.cdc2.
    Type: Grant
    Filed: April 29, 1997
    Date of Patent: July 11, 2000
    Assignee: CropDesign N.V.
    Inventor: Peter Crook Lloyd John
  • Patent number: 6087376
    Abstract: Lobeline and nicotine evoke [.sup.3 H]overflow from rat striatal slices preloaded with [.sup.3 H]dopamine ([.sup.3 H]DA). The lobeline-evoked overflow is calcium-independent and not antagonized by mecamylamine, suggesting a mechanism of action other than the stimulation of nicotinic receptors. Whereas nicotine stimulates nicotinic receptors, lobeline inhibits [.sup.3 H]DA uptake into synaptic vesicles and striatal synaptosomes. The results suggest that different mechanisms are responsible for the increase in striatal DA release evoked by lobeline and nicotine. [.sup.3 H]-Dihydrotetrabenazine [.sup.3 H]DTBZ), used routinely to probe a high-affinity binding site-on the vesicular monoamine transporter (VMAT2) binds to vesicle membranes from rat striatum. Lobeline inhibits [.sup.3 H]DTBZ binding with an IC.sub.50 of 0.90 .mu.M, consistent with its IC.sub.50 of 0.88 .mu.M for inhibition of [.sup.3 H]DA uptake into vesicles.
    Type: Grant
    Filed: June 3, 1998
    Date of Patent: July 11, 2000
    Assignee: University of Kentucky Research Foundation
    Inventors: Peter A. Crooks, Linda P. Dwoskin
  • Patent number: 5859295
    Abstract: This invention relates to canvanine analogs, their pharmaceutical compositions, and a method for treatment of cancer, particularly pancreatic cancer.
    Type: Grant
    Filed: June 18, 1996
    Date of Patent: January 12, 1999
    Assignee: University of Kentucky Research Foundation
    Inventors: Peter A. Crooks, Gerald A. Rosenthal
  • Patent number: 5830904
    Abstract: Methods are disclosed that suggest the use of lobeline and analogs thereof in treating individuals for drug dependence and withdrawal and for eating disorders.
    Type: Grant
    Filed: February 5, 1997
    Date of Patent: November 3, 1998
    Assignee: University of Kentucky Research Foundation
    Inventors: Peter A. Crooks, Linda P. Dwoskin
  • Patent number: 5776957
    Abstract: Optically active nornicotine compounds as a treatment for dopamine-related conditions and disease states. Such disease states include the treatment of myasthenia gravis, Parkinson's disease, Alzheimer's disease, schizophrenia, eating disorders, ulcers, drug addiction and as a substitute for psycho-stimulant self-administration.
    Type: Grant
    Filed: November 15, 1996
    Date of Patent: July 7, 1998
    Assignee: The University of Kentucky Research Foundation
    Inventors: Peter A. Crooks, Linda Phyliss Dwoskin, Michael Thomas Bardo
  • Patent number: 5750862
    Abstract: The present invention is directed to a method for controlling plant cell growth comprising modulating the level and or catalytic activity of a cell cycle control protein in said plant cell for a time and under conditions sufficient to control cell division. Preferably, the cell cycle control protein is p3.sup.4cdc2 or like molecule and the plant is a monocotyledonous plant or dicotyledonous plant.
    Type: Grant
    Filed: June 1, 1993
    Date of Patent: May 12, 1998
    Assignee: The Australian National University
    Inventor: Peter Crook Lloyd John
  • Patent number: 5691365
    Abstract: Nicotine analogs that have nicotinic receptor antagonist properties. These compounds have been shown to competitively inhibit dopamine release induced by nicotine. The nicotine analog compounds are useful in the treatment of nicotine abuse, smoking cessation therapy, as an antidote for nicotine intoxication, treatment of cognitive disorders such as Alzheimer's disease and for the treatment of Parkinson's disease.
    Type: Grant
    Filed: July 18, 1995
    Date of Patent: November 25, 1997
    Assignee: University of Kentucky Research Foundation
    Inventors: Peter A. Crooks, Linda P. Dwoskin, Alain Ravard
  • Patent number: 5681964
    Abstract: Prodrugs containing an active drug molecule linked to a polyethylene glycol group, and a method of use thereof are described. Exemplary soluble ester prodrugs contain naproxen, triamcinolone acetonide, gancyclovir, taxol, cyclosporin, dideoxyinosine, trihydroxy steroids, and flurbiprofen molecules linked to polyethylene glycol (PEG) groups. Pharmaceutical compositions containing these prodrugs, and a method of using these esters for treating disease states or symptoms are also described.
    Type: Grant
    Filed: October 5, 1994
    Date of Patent: October 28, 1997
    Assignee: University of Kentucky Research Foundation
    Inventors: Paul Ashton, Thomas J. Smith, Peter G. Glavinos, John D. Conklin, Jr., Peter A. Crooks, Robert M. Riggs, Tadeusz Cynkowski, Grazyna Cynkowska
  • Patent number: 5616707
    Abstract: Patients susceptible to or suffering from central nervous system disorders are treated by administering an effective amount of an aryl substituted olefinic amine compound or an aryl substituted acetylenic compound. Exemplary compounds are (E)-N-methyl-4-[3-(6-methylpyridin)yl]-3-butene-1-amine and N-methyl-4-(3-pyridinyl)-3-butyne-1-amine.
    Type: Grant
    Filed: January 6, 1995
    Date of Patent: April 1, 1997
    Inventors: Peter A. Crooks, William S. Caldwell, Gary M. Dull, Balwinder S. Bhatti, Niranjan M. Deo, Alain Ravard
  • Patent number: 5561225
    Abstract: The present invention provides for the preparation and use of ribo- and deoxyribo-nucleosides and polynucleotide analogs. The polynucleotide analogs are made of polynucleosides which contain sulfonate and sulfonamide linkages.
    Type: Grant
    Filed: September 19, 1990
    Date of Patent: October 1, 1996
    Assignee: Southern Research Institute
    Inventors: Joseph A. Maddry, Robert C. Reynolds, John A. Secrist, John A. Montgomery, Peter A. Crooks