Abstract: A multi-compartment bottle includes an upper compartment having a bottom, an open mouth opposite the bottom, and a sidewall cooperating with the bottom to bound an internal reservoir. A lid is fit to the open mouth to enclose the internal reservoir. The bottle further includes a lower compartment separate from the upper compartment, having a base, an open top opposite the base, and a wall cooperating with the base to bound an internal chamber. The bottom of the upper compartment is applicable to the open top of the lower compartment to enclose the internal chamber. The lower compartment includes engagement structures which extend into the internal chamber from the wall to define a hold in the lower compartment.